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Research ArticleOriginal Research
Open Access

Regional Neuronal Network Failure and Cognition in Late-Onset Sporadic Alzheimer Disease

S.F. Carter, K.V. Embleton, J.M. Anton-Rodriguez, A. Burns, M.A.L. Ralph and K. Herholz
American Journal of Neuroradiology June 2014, 35 (6 suppl) S18-S30; DOI: https://doi.org/10.3174/ajnr.A3895
S.F. Carter
aFrom the Wolfson Molecular Imaging Centre (S.F.C., J.M.A.-R., K.H.)
bInstitute of Population Health, Neuroscience and Aphasia Research Unit (S.F.C., M.A.L.R.)
eAlzheimer Neurobiology Centre (S.F.C.), Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.
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K.V. Embleton
cSchool of Psychological Sciences (K.V.E.)
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J.M. Anton-Rodriguez
aFrom the Wolfson Molecular Imaging Centre (S.F.C., J.M.A.-R., K.H.)
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A. Burns
dInstitute of Brain, Behaviour and Mental Health (A.B., K.H.), University of Manchester, Manchester, UK
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M.A.L. Ralph
bInstitute of Population Health, Neuroscience and Aphasia Research Unit (S.F.C., M.A.L.R.)
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K. Herholz
aFrom the Wolfson Molecular Imaging Centre (S.F.C., J.M.A.-R., K.H.)
dInstitute of Brain, Behaviour and Mental Health (A.B., K.H.), University of Manchester, Manchester, UK
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References

  1. 1.↵
    1. Papez JW
    . A proposed mechanism of emotion. Archives of Neurology and Psychiatry 1937;38:725–43
    CrossRefWeb of Science
  2. 2.↵
    1. Maclean PD
    . Some psychiatric implications of physiological studies on frontotemporal portion of limbic system (visceral brain). Electroencephalogr Clin Neurophysiol 1952;4:407–18
    CrossRefPubMed
  3. 3.↵
    1. Scoville WB,
    2. Milner B
    . Loss of recent memory after bilateral hippocampal lesions. J Neurol Neurosurg Psychiatry 1957;20:11–21
    FREE Full Text
  4. 4.↵
    1. Aggleton JP,
    2. Brown MW
    . Episodic memory, amnesia, and the hippocampal-anterior thalamic axis. Behav Brain Sci 1999;22:425–44, discussion 444–89
    CrossRefPubMedWeb of Science
  5. 5.↵
    1. Harvey DY,
    2. Wei T,
    3. Ellmore TM,
    4. et al
    . Neuropsychological evidence for the functional role of the uncinate fasciculus in semantic control. Neuropsychologia 2013;8:00042–40
  6. 6.↵
    1. Reijmer YD,
    2. Leemans A,
    3. Caeyenberghs K,
    4. et al
    . Disruption of cerebral networks and cognitive impairment in Alzheimer disease. Neurology 2013;13:13
  7. 7.↵
    1. Zhou J,
    2. Greicius MD,
    3. Gennatas ED,
    4. et al
    . Divergent network connectivity changes in behavioural variant frontotemporal dementia and Alzheimer's disease. Brain 2010;133:1352–67
    Abstract/FREE Full Text
  8. 8.↵
    1. Braak H,
    2. Braak E
    . Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol 1991;82:239–59
    CrossRefPubMedWeb of Science
  9. 9.↵
    1. Braak H,
    2. Braak E
    . Frequency of stages of Alzheimer-related lesions in different age categories. Neurobiol Aging 1997;18:351–57
    CrossRefPubMedWeb of Science
  10. 10.↵
    1. Thal DR,
    2. Rub U,
    3. Orantes M,
    4. et al
    . Phases of A beta-deposition in the human brain and its relevance for the development of AD. Neurology 2002;58:1791–800
    CrossRefPubMed
  11. 11.↵
    1. Thal DR,
    2. Rub U,
    3. Schultz C,
    4. et al
    . Sequence of Abeta-protein deposition in the human medial temporal lobe. J Neuropathol Exp Neurol 2000;59:733–48
    PubMedWeb of Science
  12. 12.↵
    1. Fox NC,
    2. Cousens S,
    3. Scahill R,
    4. et al
    . Using serial registered brain magnetic resonance imaging to measure disease progression in Alzheimer disease: power calculations and estimates of sample size to detect treatment effects. Arch Neurol 2000;57:339–44
    CrossRefPubMedWeb of Science
  13. 13.↵
    1. Chua TC,
    2. Wen W,
    3. Slavin MJ,
    4. et al
    . Diffusion tensor imaging in mild cognitive impairment and Alzheimer's disease: a review. Curr Opin Neurol 2008;21:83–92
    CrossRefPubMedWeb of Science
  14. 14.↵
    1. Frisoni GB,
    2. Fox NC,
    3. Jack CR Jr.,
    4. et al
    . The clinical use of structural MRI in Alzheimer disease. Nat Rev Neurol 2010;6:67–77
    CrossRefPubMedWeb of Science
  15. 15.↵
    1. Herholz K
    . Cerebral glucose metabolism in preclinical and prodromal Alzheimer's disease. Expert Rev Neurother 2010;10:1667–73
    CrossRefPubMed
  16. 16.↵
    1. Filippi M,
    2. Agosta F
    . Structural and functional network connectivity breakdown in Alzheimer's disease studied with magnetic resonance imaging techniques. J Alzheimers Dis 2011;24:455–74
    PubMed
  17. 17.↵
    1. Bozoki AC,
    2. Korolev IO,
    3. Davis NC,
    4. et al
    . Disruption of limbic white matter pathways in mild cognitive impairment and Alzheimer's disease: a DTI/FDG-PET study. Hum Brain Mapp 2012;33:1792–802
    CrossRefPubMedWeb of Science
  18. 18.↵
    1. Villain N,
    2. Fouquet M,
    3. Baron JC,
    4. et al
    . Sequential relationships between grey matter and white matter atrophy and brain metabolic abnormalities in early Alzheimer's disease. Brain 2010;133:3301–14
    Abstract/FREE Full Text
  19. 19.↵
    1. Yakushev I,
    2. Schreckenberger M,
    3. Muller MJ,
    4. et al
    . Functional implications of hippocampal degeneration in early Alzheimer's disease: a combined DTI and PET study. Eur J Nucl Med Mol Imaging 2011;38:2219–27
    CrossRefPubMed
  20. 20.↵
    1. Carter SF,
    2. Caine D,
    3. Burns A,
    4. et al
    . Staging of the cognitive decline in Alzheimer's disease: insights from a detailed neuropsychological investigation of mild cognitive impairment and mild Alzheimer's disease. Int J Geriatr Psychiatry 2012;27:423–32
    PubMed
  21. 21.↵
    1. Wilson RS,
    2. Leurgans SE,
    3. Boyle PA,
    4. et al
    . Cognitive decline in prodromal Alzheimer disease and mild cognitive impairment. Arch Neurol 2011;68:351–56
    CrossRefPubMedWeb of Science
  22. 22.↵
    1. Acosta-Cabronero J,
    2. Patterson K,
    3. Fryer TD,
    4. et al
    . Atrophy, hypometabolism and white matter abnormalities in semantic dementia tell a coherent story. Brain 2011;134:2025–35
    Abstract/FREE Full Text
  23. 23.↵
    1. Catani M,
    2. Thiebaut de Schotten M
    . A diffusion tensor imaging tractography atlas for virtual in vivo dissections. Cortex 2008;44:1105–32
    CrossRefPubMedWeb of Science
  24. 24.↵
    1. van Velden FH,
    2. Kloet RW,
    3. van Berckel BN,
    4. et al
    . HRRT versus HR+ human brain PET studies: an interscanner test-retest study. J Nucl Med 2009;50:693–702
    Abstract/FREE Full Text
  25. 25.↵
    1. McKhann G,
    2. Drachman D,
    3. Folstein M,
    4. et al
    . Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 1984;34:939–44
    CrossRefPubMed
  26. 26.↵
    1. Petersen RC
    . Mild cognitive impairment as a diagnostic entity. J Intern Med 2004;256:183–94
    CrossRefPubMedWeb of Science
  27. 27.↵
    1. Jones DK,
    2. Pierpaoli C
    . Contribution of cardiac pulsation to variability of tractography results. In: Proceedings of the 13th Scientific Meeting of the International Society for Magnetic Resonance in Medicine, Miami Beach, Florida. May 7–13, 2005
  28. 28.↵
    1. de Jong H,
    2. van Velden FHP,
    3. Kloet RW,
    4. et al
    . Performance evaluation of the ECAT HRRT: an LSO-LYSO double layer high resolution, high sensitivity scanner. Phys Med Biol 2007;52:1505–26
    CrossRefPubMedWeb of Science
  29. 29.↵
    1. Wienhard K,
    2. Schmand M,
    3. Casey ME,
    4. et al
    . The ECAT HRRT: performance and first clinical application of the new high resolution research tomograph. IEEE Trans Nucl Sci 2002;49:104–10
    CrossRef
  30. 30.↵
    1. Michel C,
    2. Schmand M,
    3. Liu X,
    4. et al
    . Reconstruction strategies for the HRRT. Nuclear Science Symposium Conference Record 2000 IEEE 2000;2:14/207–15/212
  31. 31.↵
    1. Byars LG,
    2. Sibomana M,
    3. Burbar Z,
    4. et al
    . Variance reduction on randoms from coincidence histograms for the HRRT. Nuclear Science Symposium Conference Record 2005 IEEE 2005;5:2622–26
  32. 32.↵
    1. Watson CC
    . New, faster, image-based scatter correction for 3D PET. Nuclear Science IEEE Transactions on 2000;47:1587–94
    CrossRef
  33. 33.↵
    1. Sibomana M,
    2. Byars L,
    3. Panin V,
    4. et al
    . Simultaneous measurement of transmission and emission contamination using a collimated /sup 137/Cs point source for the HRRT. Nuclear Science Symposium Conference Record 2004 IEEE 2004;4:2647–51
    CrossRef
  34. 34.↵
    1. Embleton KV,
    2. Haroon HA,
    3. Morris DM,
    4. et al
    . Distortion correction for diffusion-weighted MRI tractography and fMRI in the temporal lobes. Hum Brain Mapp 2010;31:1570–87
    CrossRefPubMedWeb of Science
  35. 35.↵
    1. Smith SM,
    2. Nichols TE
    . Threshold-free cluster enhancement: addressing problems of smoothing, threshold dependence and localisation in cluster inference. Neuroimage 2009;44:83–98
    CrossRefPubMedWeb of Science
  36. 36.↵
    1. Stopford CL,
    2. Snowden JS,
    3. Thompson JC,
    4. et al
    . Variability in cognitive presentation of Alzheimer's disease. Cortex 2008;44:185–95
    CrossRefPubMedWeb of Science
  37. 37.↵
    1. Visser M,
    2. Jefferies E,
    3. Lambon Ralph MA
    . Semantic processing in the anterior temporal lobes: a meta-analysis of the functional neuroimaging literature. J Cogn Neurosci 2010;22:1083–94
    CrossRefPubMedWeb of Science
  38. 38.↵
    1. Chetelat G,
    2. Desgranges B,
    3. Landeau B,
    4. et al
    . Direct voxel-based comparison between grey matter hypometabolism and atrophy in Alzheimer's disease. Brain 2008;131:60–71
    Abstract/FREE Full Text
  39. 39.↵
    1. Fouquet M,
    2. Desgranges B,
    3. Landeau B,
    4. et al
    . Longitudinal brain metabolic changes from amnestic mild cognitive impairment to Alzheimer's disease. Brain 2009;132:2058–67
    Abstract/FREE Full Text
  40. 40.↵
    1. Kuczynski B,
    2. Targan E,
    3. Madison C,
    4. et al
    . White matter integrity and cortical metabolic associations in aging and dementia. Alzheimers Dement 2010;6:54–62
    CrossRefPubMed
  41. 41.↵
    1. Catheline G,
    2. Periot O,
    3. Amirault M,
    4. et al
    . Distinctive alterations of the cingulum bundle during aging and Alzheimer's disease. Neurobiol Aging 2010;31:1582–92
    CrossRefPubMedWeb of Science
  42. 42.↵
    1. Trojanowski JQ,
    2. Vandeerstichele H,
    3. Korecka M,
    4. et al
    . Update on the biomarker core of the Alzheimer's Disease Neuroimaging Initiative subjects. Alzheimers Dement 2010;6:230–38
    CrossRefPubMedWeb of Science
  43. 43.↵
    1. Forster S,
    2. Grimmer T,
    3. Miederer I,
    4. et al
    . Regional expansion of hypometabolism in Alzheimer's disease follows amyloid deposition with temporal delay. Biol Psychiatry 2012;71:792–97
    CrossRefPubMedWeb of Science
  44. 44.↵
    1. Selden NR,
    2. Gitelman DR,
    3. Salamon-Murayama N,
    4. et al
    . Trajectories of cholinergic pathways within the cerebral hemispheres of the human brain. Brain 1998;121(pt 12):2249–57
    Abstract/FREE Full Text
  45. 45.↵
    1. Haense C,
    2. Kalbe E,
    3. Herholz K,
    4. et al
    . Cholinergic system function and cognition in mild cognitive impairment. Neurobiol Aging 2012;33:867–77
    CrossRefPubMedWeb of Science
  46. 46.↵
    1. Desgranges B,
    2. Baron JC,
    3. de la Sayette V,
    4. et al
    . The neural substrates of memory systems impairment in Alzheimer's disease: a PET study of resting brain glucose utilization. Brain 1998;121(pt 4):611–31
    Abstract/FREE Full Text
  47. 47.↵
    1. Herholz K,
    2. Salmon E,
    3. Perani D,
    4. et al
    . Discrimination between Alzheimer dementia and controls by automated analysis of multicenter FDG PET. Neuroimage 2002;17:302–16
    CrossRefPubMedWeb of Science
  48. 48.↵
    1. Ishii K,
    2. Sasaki M,
    3. Yamaji S,
    4. et al
    . Relatively preserved hippocampal glucose metabolism in mild Alzheimer's disease. Dement Geriatr Cogn Disord 1998;9:317–22
    CrossRefPubMedWeb of Science
  49. 49.↵
    1. Minoshima S,
    2. Giordani B,
    3. Berent S,
    4. et al
    . Metabolic reduction in the posterior cingulate cortex in very early Alzheimer's disease. Ann Neurol 1997;42:85–94
    CrossRefPubMedWeb of Science
  50. 50.↵
    1. De Santi S,
    2. de Leon MJ,
    3. Rusinek H,
    4. et al
    . Hippocampal formation glucose metabolism and volume losses in MCI and AD. Neurobiol Aging 2001;22:529–39
    CrossRefPubMedWeb of Science
  51. 51.↵
    1. Mosconi L,
    2. De Santi S,
    3. Li J,
    4. et al
    . Hippocampal hypometabolism predicts cognitive decline from normal aging. Neurobiol Aging 2008;29:676–92
    CrossRefPubMedWeb of Science
  52. 52.↵
    1. Mosconi L,
    2. Sorbi S,
    3. de Leon MJ,
    4. et al
    . Hypometabolism exceeds atrophy in presymptomatic early-onset familial Alzheimer's disease. J Nucl Med 2006;47:1778–86
    Abstract/FREE Full Text
  53. 53.↵
    1. Mosconi L,
    2. Tsui WH,
    3. De Santi S,
    4. et al
    . Reduced hippocampal metabolism in MCI and AD: automated FDG-PET image analysis. Neurology 2005;64:1860–67
    CrossRef
  54. 54.↵
    1. Nestor PJ,
    2. Fryer TD,
    3. Smielewski P,
    4. et al
    . Limbic hypometabolism in Alzheimer's disease and mild cognitive impairment. Ann Neurol 2003;54:343–51
    CrossRefPubMedWeb of Science
  55. 55.↵
    1. Segobin SH,
    2. Matthews JC,
    3. Markiewicz PJ,
    4. et al
    . A hybrid between region-based and voxel-based methods for partial volume correction in PET. Nuclear Science Symposium Conference Record (NSS/MIC) 2010 IEEE 2010;3073–78
  56. 56.↵
    1. Gutierrez D,
    2. Montandon M-L,
    3. Assal F,
    4. et al
    . Anatomically guided voxel-based partial volume effect correction in brain PET: impact of MRI segmentation. Comput Med Imaging Graph 2012;36:610–19
    CrossRefPubMed
  57. 57.↵
    1. Ashburner J,
    2. Friston KJ
    . Unified segmentation. Neuroimage 2005;26:839–51
    CrossRefPubMedWeb of Science
  58. 58.↵
    1. Ashburner J
    . A fast diffeomorphic image registration algorithm. Neuroimage 2007;38:95–113
    CrossRefPubMedWeb of Science
  59. 59.↵
    1. Smith SM,
    2. Jenkinson M,
    3. Johansen-Berg H,
    4. et al
    . Tract-based spatial statistics: voxelwise analysis of multi-subject diffusion data. Neuroimage 2006;31:1487–1505
    CrossRefPubMedWeb of Science
  60. 60.↵
    1. Smith SM,
    2. Johansen-Berg H,
    3. Jenkinson M,
    4. et al
    . Acquisition and voxelwise analysis of multi-subject diffusion data with tract-based spatial statistics. Nat Protoc 2007;2:499–503
    CrossRefPubMedWeb of Science
  61. 61.↵
    1. Hammers A,
    2. Allom R,
    3. Koepp MJ,
    4. et al
    . Three-dimensional maximum probability atlas of the human brain, with particular reference to the temporal lobe. Hum Brain Mapp 2003;19:224–47
    CrossRefPubMedWeb of Science
  62. 62.↵
    1. Hua K,
    2. Zhang J,
    3. Wakana S,
    4. et al
    . Tract probability maps in stereotaxic spaces: analyses of white matter anatomy and tract-specific quantification. Neuroimage 2008;39:336–47
    CrossRefPubMedWeb of Science
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Cite this article
S.F. Carter, K.V. Embleton, J.M. Anton-Rodriguez, A. Burns, M.A.L. Ralph, K. Herholz
Regional Neuronal Network Failure and Cognition in Late-Onset Sporadic Alzheimer Disease
American Journal of Neuroradiology Jun 2014, 35 (6 suppl) S18-S30; DOI: 10.3174/ajnr.A3895

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Regional Neuronal Network Failure and Cognition in Late-Onset Sporadic Alzheimer Disease
S.F. Carter, K.V. Embleton, J.M. Anton-Rodriguez, A. Burns, M.A.L. Ralph, K. Herholz
American Journal of Neuroradiology Jun 2014, 35 (6 suppl) S18-S30; DOI: 10.3174/ajnr.A3895
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