Article Figures & Data
Figures
- Fig 1.
Axial DWI at the level of the ON heads in a control participant (A) and in 2 patients with clinically proven papilledema (B and C) showing lack of any hyperintensity at the ON head in the control participant, with a signal at the ON heads less than that of the globe margins. In contrast, mild (B) and prominent (C) hyperintensity at the ON heads is observed in patients with papilledema, with signal intensity minimally and substantially higher compared with the globe margins.
- Fig 2.
Axial diffusion-weighted image (A) and ADC map (B) in a patient with clinically proven papilledema showing prominent hyperintensity at both ON heads with a corresponding hypointense signal on the ADC map suggestive of restricted diffusion.
Tables
- Table 1:
Presence of DWI hyperintensity at ON heads in patients with papilledema and control participants
Control Participants (n = 20) Patients (n = 19) 1 Eye Both Eyes 1/Both Eyes 1 Eye Both Eyes 1/Both Eyes Reader 1 5.0% (1/20) 0% (0/20) 5.0% (1/20) 26.3% (5/19) 26.3% (5/19) 52.6% (10/19) Reader 2 10.0% (2/20) 0% (0/20) 10.0% (2/20) 36.8% (7/19) 42.1% (8/19) 78.9% (15/19) - Table 2:
Fisher exact test P values for difference between patients with papilledema and control participants
1 Eye Both Eyes 1/Both Eyes Reader 1 .091 .020 .001 Reader 2 .065 .001 <.001 Control Participants 40 Total Eyes Patients 38 Total Eyes P Value Reader 1 2.5% (1/40) 39.5% (15/38) <.001 Reader 2 5.0% (2/40) 60.5% (23/38) <.001 - Table 4:
Presence of DWI hyperintensity at ON heads in patients stratified by Frisen papilledema grade
Grade II or Higher Grade III or Higher Grade IV or Higher Patients (n = 16) Total Eyes (n = 28) Patients (n = 11) Total Eyes (n = 19) Patients (n = 4) Total Eyes (n = 7) Reader 1 56.3% (9/16) 42.9% (12/28) 63.6% (7/11) 57.9% (11/19) 100.0% (4/4) 85.7% (6/7) Reader 2 81.3% (13/16) 64.3% (18/28) 81.8% (9/11) 78.9% (15/19) 100.0% (4/4) 85.7% (6/7)
