Skip to main content
Advertisement

Main menu

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home

User menu

  • Alerts
  • Log in

Search

  • Advanced search
American Journal of Neuroradiology
American Journal of Neuroradiology

American Journal of Neuroradiology

ASHNR American Society of Functional Neuroradiology ASHNR American Society of Pediatric Neuroradiology ASSR
  • Alerts
  • Log in

Advanced Search

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home
  • Follow AJNR on Twitter
  • Visit AJNR on Facebook
  • Follow AJNR on Instagram
  • Join AJNR on LinkedIn
  • RSS Feeds

AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticleFunctional

Anatomic MR Imaging and Functional Diffusion Tensor Imaging of Peripheral Nerve Tumors and Tumorlike Conditions

A. Chhabra, R.S. Thakkar, G. Andreisek, M. Chalian, A.J. Belzberg, J. Blakeley, A. Hoke, G.K. Thawait, J. Eng and J.A. Carrino
American Journal of Neuroradiology April 2013, 34 (4) 802-807; DOI: https://doi.org/10.3174/ajnr.A3316
A. Chhabra
aFrom the Russell H. Morgan Department of Radiology and Radiological Science (A.C., R.S.T., M.C., G.K.T., J.E., J.A.C.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
R.S. Thakkar
aFrom the Russell H. Morgan Department of Radiology and Radiological Science (A.C., R.S.T., M.C., G.K.T., J.E., J.A.C.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
G. Andreisek
dDiagnostic and Interventional Radiology (G.A.), Zurich University Hospital, Zurich, Switzerland.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
M. Chalian
aFrom the Russell H. Morgan Department of Radiology and Radiological Science (A.C., R.S.T., M.C., G.K.T., J.E., J.A.C.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
A.J. Belzberg
bDepartments of Neurosurgery (A.J.B.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
J. Blakeley
cNeurology (J.B., A.H.), Johns Hopkins Hospital, Baltimore, Maryland
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
A. Hoke
cNeurology (J.B., A.H.), Johns Hopkins Hospital, Baltimore, Maryland
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
G.K. Thawait
aFrom the Russell H. Morgan Department of Radiology and Radiological Science (A.C., R.S.T., M.C., G.K.T., J.E., J.A.C.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
J. Eng
aFrom the Russell H. Morgan Department of Radiology and Radiological Science (A.C., R.S.T., M.C., G.K.T., J.E., J.A.C.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
J.A. Carrino
aFrom the Russell H. Morgan Department of Radiology and Radiological Science (A.C., R.S.T., M.C., G.K.T., J.E., J.A.C.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • Responses
  • References
  • PDF
Loading

Article Figures & Data

Figures

  • Tables
  • Fig. 1.
    • Download figure
    • Open in new tab
    • Download powerpoint
    Fig. 1.

    ADC on DWI and DTI. There is a very good Pearson correlation (r = 0.90, P < .001).

  • Fig. 2.
    • Download figure
    • Open in new tab
    • Download powerpoint
    Fig. 2.

    A, MPNST. 3D STIR SPACE maximum-intensity-projection image in 56-year-old man presenting with a painless palpable mass in the right supraclavicular region for 6 months, which was steadily increasing in size with progressive weakness of right upper extremity. The mass involves the C5 and C6 nerve roots and upper trunk (arrow). B, Corresponding DTI shows disorganization and partial (near-complete) disruption of tracts (arrows). The ADC is 0.9 × 10−3 mm2/s.

  • Fig. 3.
    • Download figure
    • Open in new tab
    • Download powerpoint
    Fig. 3.

    A, BPNST. 3D STIR SPACE maximum-intensity-projection image in a 34-year-old man presenting with a painless palpable mass in the right supraclavicular region. The mass remained stable during a 12-month period. The mass (large arrow) involves the distal right C7 nerve root (small arrow) and the upper trunk of the brachial plexus. B, Corresponding DTI shows swelling of the right C7 nerve root (small arrow) with partial disruption of the tracts (large arrow). The ADC is 1.7 × 10−3 mm2/s.

  • Fig. 4.
    • Download figure
    • Open in new tab
    • Download powerpoint
    Fig. 4.

    A, Lymphoma. 3D STIR SPACE maximum-intensity-projection image in 65-year-old man presenting with progressively increasing weakness of the right arm during a few months. There was enlargement and abnormal hyperintense signal of multiple right brachial plexus nerve roots and trunks. The C6 nerve was the most abnormal (arrow). B, Corresponding DTI shows near-normal tracts. The ADC is 0.7 × 10−3 mm2/s.

  • Fig. 5.
    • Download figure
    • Open in new tab
    • Download powerpoint
    Fig. 5.

    A, CMT 1A disease. 3D STIR SPACE maximum-intensity-projection image in a 28-year-old woman presenting with pain in the lower midline thoracic region for many months. A diffuse symmetrically enlarged brachial plexus was seen bilaterally (arrows). B, Corresponding DTI shows near-normal tracts (arrows), given the limitation of suboptimal SNR near the spine and peripheral areas. The ADC was 2.0 and 1.9 × 10−3 mm2/s on right and left sides, respectively.

Tables

  • Figures
  • Patient demographics and results

    Patient InformationData
    Demographics and imagingNo. = 29, male/female = 13:16, mean age = 41 ± 18 yr, range = 11–83 yr;a
        characteristicsleft/right = 9:21 lesions
    DTI ADC = 24 patients, DWI ADC = 21 patients
    No. of directions in DTI: 14 patients with 12, 10 patients with 20 directions, respectively
    Benign and malignant lesionsBenign = 25, malignant = 5
    No difference in terms of age (benign = 40 ± 18 versus malignant = 45 ± 19 yr), sex (benign, male/female = 12:13 versus malignant, male/female = 3:2) (P > .05), FA and ADC values (P >0.05);a
    DTI ADC different (P = .001), benign = 1.848 ± 0.40 versus malignant = 0.900 ± 0.25 × 10−3 mm2/s;a
    DWI ADC not different (P > .05), benign = 1.745 ± 0.44 vs malignant = 1.267 ± 0.35 × 10−3 mm2/s;a
    Interobserver reliability ADC: ICC = 0.988 (95% CI, 0.976–0.994), excellenta
    Abnormal and contralateral normalFA significantly different (P < .001), abnormal = 0.221 ± 0.09, normal = 0.344 ± 0.12;a
        nervesInterobserver reliability FA: ICC = 0.970 (95% CI, 0.946–0.991), excellenta
    DTI ADC among benign lesions between different (12 and 20) directionsNot statistically different (P > .05)
    DTI ADC on 12 directions: 1.627 ± 0.600
    DTI ADC on 20 directions: 1.520 ± 0.390
    DTI ADC and DWI ADCNot statistically different (P > .05)
    ICC = 0.943 (95% CI, 0.836–0.980), excellent intermethod reliability
    Very good Pearson correlation (r = 0.90, P < .001)
    • ↵a years.

PreviousNext
Back to top

In this issue

American Journal of Neuroradiology: 34 (4)
American Journal of Neuroradiology
Vol. 34, Issue 4
1 Apr 2013
  • Table of Contents
  • Index by author
Advertisement
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on American Journal of Neuroradiology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Anatomic MR Imaging and Functional Diffusion Tensor Imaging of Peripheral Nerve Tumors and Tumorlike Conditions
(Your Name) has sent you a message from American Journal of Neuroradiology
(Your Name) thought you would like to see the American Journal of Neuroradiology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Cite this article
A. Chhabra, R.S. Thakkar, G. Andreisek, M. Chalian, A.J. Belzberg, J. Blakeley, A. Hoke, G.K. Thawait, J. Eng, J.A. Carrino
Anatomic MR Imaging and Functional Diffusion Tensor Imaging of Peripheral Nerve Tumors and Tumorlike Conditions
American Journal of Neuroradiology Apr 2013, 34 (4) 802-807; DOI: 10.3174/ajnr.A3316

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
0 Responses
Respond to this article
Share
Bookmark this article
Anatomic MR Imaging and Functional Diffusion Tensor Imaging of Peripheral Nerve Tumors and Tumorlike Conditions
A. Chhabra, R.S. Thakkar, G. Andreisek, M. Chalian, A.J. Belzberg, J. Blakeley, A. Hoke, G.K. Thawait, J. Eng, J.A. Carrino
American Journal of Neuroradiology Apr 2013, 34 (4) 802-807; DOI: 10.3174/ajnr.A3316
del.icio.us logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Purchase

Jump to section

  • Article
    • Abstract
    • ABBREVIATIONS:
    • Materials and Methods
    • Results
    • Discussion
    • Conclusions
    • Acknowledgments
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • Responses
  • References
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • Current whole-body MRI applications in the neurofibromatoses: NF1, NF2, and schwannomatosis
  • Diffusivity Measurements Differentiate Benign from Malignant Lesions in Patients with Peripheral Neuropathy or Plexopathy
  • Crossref (105)
  • Google Scholar

This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.

  • Magnetic resonance neurography: current perspectives and literature review
    Avneesh Chhabra, Ananth J. Madhuranthakam, Gustav Andreisek
    European Radiology 2018 28 2
  • New technologies for the assessment of neuropathies
    Roberto Gasparotti, Luca Padua, Chiara Briani, Giuseppe Lauria
    Nature Reviews Neurology 2017 13 4
  • Peripheral nerve diffusion tensor imaging: Overview, pitfalls, and future directions
    Tina Jeon, Maggie M. Fung, Kevin M. Koch, Ek T. Tan, Darryl B. Sneag
    Journal of Magnetic Resonance Imaging 2018 47 5
  • Magnetic Resonance Neurography of Peripheral Nerve Tumors and Tumorlike Conditions
    Shivani Ahlawat, Avneesh Chhabra, Jaishri Blakely
    Neuroimaging Clinics of North America 2014 24 1
  • Evaluation of 18F-FDG PET and MRI in differentiating benign and malignant peripheral nerve sheath tumors
    Stephen M. Broski, Geoffrey B. Johnson, Benjamin M. Howe, Mark A. Nathan, Doris E. Wenger, Robert J. Spinner, Kimberly K. Amrami
    Skeletal Radiology 2016 45 8
  • Current whole-body MRI applications in the neurofibromatoses
    Shivani Ahlawat, Laura M. Fayad, Muhammad Shayan Khan, Miriam A. Bredella, Gordon J. Harris, D. Gareth Evans, Said Farschtschi, Michael A. Jacobs, Avneesh Chhabra, Johannes M. Salamon, Ralph Wenzel, Victor F. Mautner, Eva Dombi, Wenli Cai, Scott R. Plotkin, Jaishri O. Blakeley, Shivani Ahlawat, Srivandana Akshintala, Jeffrey Allen, Simone Ardern-Holmes, Robert Avery, Amedeo Azizi, Dusica Babovic-Vuksanovic, Annette Bakker, Andrea Baldwin, Fred Barker, Amanda Bergner, Chetan Bettegowda, Sucharita Bhaumik, Larissa Bilaniuk, Kim Bischoff, Jaishri Blakely, Diana Bradford, Miriam Bredella, Wenli Cai, John Carino, Avneesh Chabra, Patricia Ciavarelli, Wade Clapp, Stephen Connor, Albert Cornelius, Tambra Dahlheimer, Stephanie Davis, Peter de Blank, Vidya Dhote;, Joni Doherty, Eva Dombi, William Dudley, Rachel Ershler, D. Gareth Evans, Laura Fayad, Cristina Fernandez-Valle, Rosalie Ferner, Michael Fisher, Barbara Franklin, Giulia Fulci, Tracy Galloway, Kathy Gardner, Richard Gedrich, Marco Giovannini, Amy Goldstein, Anne Goodwin, Stephane Goutagny, David Gutmann, Theresa Hadlock, Chris Halpin, C. Oliver Hanemann, Kristina Hardy, Gordon Harris, Desiree Headley, Gena Heidary, Jonathan Heller, Cynthia Hingtgen, Trent Hummel, Susan Huson, Michael Jacobs, Jennifer Janusz, Diego Jaramillo, Justin Jordan, Allen Julian, Michel Kalamarides, Matthias Karajannis, Bonnie Klein-Tasman, Pamela Knight, Bruce Korf, Shannon Langmead, Theresa LaVallee, Fawn Leigh, Donita Lightner, Carol Lin, Robert Listernick, Grant Liu, Mevo Marco, Carole Marcus, Gabriella Mariani, Staci Martin, Victor Mautner, Vanessa Merker, Michael Ferguson, Chris Moertel, Jill Morris, Katrina Morris, Kathryn North, Fabio Nunes, Roger Packer, Laura Papi, Allyson Parry, Neha Patel, Jonathan Payne, Karen Peluso, Sebastian Perreault, Scott Plotkin, Tina Poussaint, Nancy Ratner, Karlyne Reilly, Vincent Riccardi, Kent Robertson, Claas Rohl, Deborah Rukin Gold, La Rosa Salvatore, Laura Schaffner Gray, Elizabeth Schorry, Claire Semerjian, Monica Sheridan, Chie-Schin Shih, Carolyn Sidor, William Slattery, Miriam Smith, Kathy Sommer, Marigo Stathis, Matt Steensma, Anat Stemmer-Rachamimov, David Stevenson, Kari Struemph, Lara Sullivan, Mary Anne Tamula, Mary Thomas, Heather Thompson, James Tonsgard, Nicole Ullrich, Sharad Verma, David Viskochil, Ana-Maria Vranceanu, Ute Wahllander, Karin Walsh, Bradley Welling, Ralph Wenzel, Trish Whitcomb, Brigitte Widemann, Victoria Williams, David Wolf, Pamela Wolters, Kaleb Yohay
    Neurology 2016 87 7_Supplement_1
  • Diffusion Tensor Imaging Adds Diagnostic Accuracy in Magnetic Resonance Neurography
    Michael O. Breckwoldt, Christian Stock, Annie Xia, Andreas Heckel, Martin Bendszus, Mirko Pham, Sabine Heiland, Philipp Bäumer
    Investigative Radiology 2015 50 8
  • Assessment of paraspinal neurogenic tumors with diffusion-weighted MR imaging
    Ahmed Abdel Khalek Abdel Razek, Germeen Albair Ashmalla
    European Spine Journal 2018 27 4
  • Functional MR Neurography in Evaluation of Peripheral Nerve Trauma and Postsurgical Assessment
    Teodoro Martín Noguerol, Rafael Barousse, Marta Gómez Cabrera, Mariano Socolovsky, Jenny T. Bencardino, Antonio Luna
    RadioGraphics 2019 39 2
  • Diffusion tensor imaging in the musculoskeletal and peripheral nerve systems: from experimental to clinical applications
    Vito Chianca, Domenico Albano, Carmelo Messina, Claudia Maria Cinnante, Fabio Maria Triulzi, Francesco Sardanelli, Luca Maria Sconfienza
    European Radiology Experimental 2017 1 1

More in this TOC Section

  • Kurtosis and Epileptogenic Tubers: A Pilot Study
  • Glutaric Aciduria Type 1: DK vs. Conventional MRI
  • Multiparametric MRI in PEDS Pontine Glioma
Show more FUNCTIONAL

Similar Articles

Advertisement

Indexed Content

  • Current Issue
  • Accepted Manuscripts
  • Article Preview
  • Past Issues
  • Editorials
  • Editor's Choice
  • Fellows' Journal Club
  • Letters to the Editor
  • Video Articles

Cases

  • Case Collection
  • Archive - Case of the Week
  • Archive - Case of the Month
  • Archive - Classic Case

More from AJNR

  • Trainee Corner
  • Imaging Protocols
  • MRI Safety Corner
  • Book Reviews

Multimedia

  • AJNR Podcasts
  • AJNR Scantastics

Resources

  • Turnaround Time
  • Submit a Manuscript
  • Submit a Video Article
  • Submit an eLetter to the Editor/Response
  • Manuscript Submission Guidelines
  • Statistical Tips
  • Fast Publishing of Accepted Manuscripts
  • Graphical Abstract Preparation
  • Imaging Protocol Submission
  • Evidence-Based Medicine Level Guide
  • Publishing Checklists
  • Author Policies
  • Become a Reviewer/Academy of Reviewers
  • News and Updates

About Us

  • About AJNR
  • Editorial Board
  • Editorial Board Alumni
  • Alerts
  • Permissions
  • Not an AJNR Subscriber? Join Now
  • Advertise with Us
  • Librarian Resources
  • Feedback
  • Terms and Conditions
  • AJNR Editorial Board Alumni

American Society of Neuroradiology

  • Not an ASNR Member? Join Now

© 2025 by the American Society of Neuroradiology All rights, including for text and data mining, AI training, and similar technologies, are reserved.
Print ISSN: 0195-6108 Online ISSN: 1936-959X

Powered by HighWire