Correlation of MRI-Derived Apparent Diffusion Coefficients in Newly Diagnosed Gliomas with [18F]-Fluoro-L-Dopa PET: What Are We Really Measuring with Minimum ADC?

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Fig. 1.
Box-and-whisker plots outlining the distribution (mean and SD) of ADC and FDOPA SUVR measures within the minimum ADC and maximum FDOPA SUVR–defined tumor regions.
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Fig. 2.
Representative FDOPA–MR imaging fused images for patients 12 (top) and 1 (bottom). The maps from left to right are registered as contrast-enhanced T1-weighted MR imaging, ADC, and FDOPA PET, respectively. For each patient, CE MR imaging, ADC, and FDOPA maps are given without (top) and with overlaid regions of minimum ADC (red), maximum FDOPA SUVR (blue), and FDOPA-defined tumor volume (yellow). All maps are given in radiologic format.

Table 1:

Patient demographics, minimum ADC, and maximum FDOPA measures

Patient	Sex/Age (yr)	Pathology	ADC Value^{^a}			FDOPA Value^{^a}
Patient	Sex/Age (yr)	Pathology	Normal Tissue	Min ADC ROI	Max FDOPA ROI	Min ADC ROI	Max FDOPA ROI
1	M/72	GBM	550 (30)	380 (50)	550 (130)	1.42 (0.402)	1.96 (0.18)
2	M/58	GBM	530 (28)	410 (30)	670 (70)	1.32 (0.36)	2.68 (0.22)
3	F/56	GBM	550 (25)	380 (90)	750 (170)	1.10 (0.34)	2.27 (0.19)
4	M/69	GBM	540 (28)	440 (10)	920 (170)	1.12 (0.13)	2.23 (0.33)
5	M/61	GBM	540 (30)	420 (30)	770 (130)	1.20 (0.13)	2.18 (0.21)
6	F/69	GBM	520 (25)	390 (60)	640 (80)	1.79 (0.69)	3.85 (0.36)
7	M/69	GBM	520 (30)	390 (60)	710 (140)	1.49 (0.21)	2.00 (0.22)
8	F/54	GBM	520 (30)	370 (11)	670 (140)	1.72 (0.62)	2.26 (0.36)
9	M/62	GBM	540 (25)	420 (40)	1170 (310)	1.21 (0.49)	5.01 (1.20)
10	F/47	AA	530 (30)	420 (20)	660 (190)	1.47 (0.20)	1.65 (0.18)
11	F/59	GBM	510 (30)	440 (20)	840 (130)	1.09 (0.26)	1.90 (0.22)
12	M/64	GBM	520 (30)	380 (50)	710 (110)	1.55 (0.38)	2.74 (0.34)
13	M/78	GBM	530 (34)	432 (39)	725 (165)	1.17 (0.25)	1.95 (0.17)
14	M/52	GBM	514 (40)	442 (27)	675 (162)	1.34 (0.18)	1.88 (0.23)
15	M/85	GBM	561 (30)	417 (35)	845 (167)	1.44 (0.26)	2.11 (0.28)
mean (SD)			531 (29)	409 (38)	790 (151)	1.36 (0.22)	2.45 (0.88)

Note:—Min indicates minimum; Max, maximum; AA, anaplastic astrocytoma.
↵a × 10⁻⁶ mm²/s; mean (SD) ADC and FDOPA values are given for each patient including for the entire cohort.

Table 2:

Tumor volumetric measures

Patient	Max FDOPA Volume (mL)	Min ADC Volume (mL)	Overlap (%)^{^a}	Overlap (%)^{^b}
1	29.9	29.0	19.3	19.9
2	38.3	0.4	0.2	19.2
3	15.7	4.8	0.2	0.7
4	19.9	0.3	0	0
5	3.1	1.6	0	0
6	18.9	4.6	1.0	4.1
7	12.9	0.4	0.2	6.5
8	33.9	0.9	0.3	11.3
9	21.6	2.3	3.0	28.2
10	60.1	15.0	6.8	27.3
11	44.5	0.5	0	0
12	14.1	2.9	0.52	2.5
13	15.8	3.7	0.42	1.8
14	20.0	0.4	0.2	9.3
15	59.7	1.9	0.4	13.4

Note:—Min indicates minimum; Max, maximum.
↵a Overlap (ie, minimum ADC volume overlap with maximum FDOPA SUVR) expressed as a percentage of maximum FDOPA SUVR volume.
↵b Overlap (ie, minimum ADC volume overlap with maximum FDOPA SUVR) expressed as a percentage of mininum ADC volume.