Skip to main content
Advertisement

Main menu

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home

User menu

  • Alerts
  • Log in

Search

  • Advanced search
American Journal of Neuroradiology
American Journal of Neuroradiology

American Journal of Neuroradiology

ASHNR American Society of Functional Neuroradiology ASHNR American Society of Pediatric Neuroradiology ASSR
  • Alerts
  • Log in

Advanced Search

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home
  • Follow AJNR on Twitter
  • Visit AJNR on Facebook
  • Follow AJNR on Instagram
  • Join AJNR on LinkedIn
  • RSS Feeds

AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticleBrain
Open Access

Correlation of MRI-Derived Apparent Diffusion Coefficients in Newly Diagnosed Gliomas with [18F]-Fluoro-L-Dopa PET: What Are We Really Measuring with Minimum ADC?

S. Rose, M. Fay, P. Thomas, P. Bourgeat, N. Dowson, O. Salvado, Y. Gal, A. Coulthard and S. Crozier
American Journal of Neuroradiology April 2013, 34 (4) 758-764; DOI: https://doi.org/10.3174/ajnr.A3315
S. Rose
aFrom the Centre for Clinical Research (S.R.)
fAustralian e-Health Research Centre (P.B., O.S., S.R.), Commonwealth Scientific and Industrial Research Organization
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
M. Fay
dDepartment of Radiation Oncology (M.F.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
P. Thomas
eQueensland PET Service (P.T.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
P. Bourgeat
fAustralian e-Health Research Centre (P.B., O.S., S.R.), Commonwealth Scientific and Industrial Research Organization
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
N. Dowson
aFrom the Centre for Clinical Research (S.R.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
O. Salvado
fAustralian e-Health Research Centre (P.B., O.S., S.R.), Commonwealth Scientific and Industrial Research Organization
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Y. Gal
bCentre for Medical Diagnostic Technologies in Queensland (Y.G., S.C.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
A. Coulthard
cDiscipline of Medical Imaging (A.C.), University of Queensland, St Lucia, Brisbane, Australia
gDepartment of Medical Imaging (A.C.), Royal Brisbane and Women's Hospital, Herston, Brisbane, Australia.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
S. Crozier
bCentre for Medical Diagnostic Technologies in Queensland (Y.G., S.C.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • Responses
  • References
  • PDF
Loading

Article Figures & Data

Figures

  • Tables
  • Fig. 1.
    • Download figure
    • Open in new tab
    • Download powerpoint
    Fig. 1.

    Box-and-whisker plots outlining the distribution (mean and SD) of ADC and FDOPA SUVR measures within the minimum ADC and maximum FDOPA SUVR–defined tumor regions.

  • Fig. 2.
    • Download figure
    • Open in new tab
    • Download powerpoint
    Fig. 2.

    Representative FDOPA–MR imaging fused images for patients 12 (top) and 1 (bottom). The maps from left to right are registered as contrast-enhanced T1-weighted MR imaging, ADC, and FDOPA PET, respectively. For each patient, CE MR imaging, ADC, and FDOPA maps are given without (top) and with overlaid regions of minimum ADC (red), maximum FDOPA SUVR (blue), and FDOPA-defined tumor volume (yellow). All maps are given in radiologic format.

Tables

  • Figures
    • View popup
    Table 1:

    Patient demographics, minimum ADC, and maximum FDOPA measures

    PatientSex/Age (yr)PathologyADC ValueaFDOPA Valuea
    Normal TissueMin ADC ROIMax FDOPA ROIMin ADC ROIMax FDOPA ROI
    1M/72GBM550 (30)380 (50)550 (130)1.42 (0.402)1.96 (0.18)
    2M/58GBM530 (28)410 (30)670 (70)1.32 (0.36)2.68 (0.22)
    3F/56GBM550 (25)380 (90)750 (170)1.10 (0.34)2.27 (0.19)
    4M/69GBM540 (28)440 (10)920 (170)1.12 (0.13)2.23 (0.33)
    5M/61GBM540 (30)420 (30)770 (130)1.20 (0.13)2.18 (0.21)
    6F/69GBM520 (25)390 (60)640 (80)1.79 (0.69)3.85 (0.36)
    7M/69GBM520 (30)390 (60)710 (140)1.49 (0.21)2.00 (0.22)
    8F/54GBM520 (30)370 (11)670 (140)1.72 (0.62)2.26 (0.36)
    9M/62GBM540 (25)420 (40)1170 (310)1.21 (0.49)5.01 (1.20)
    10F/47AA530 (30)420 (20)660 (190)1.47 (0.20)1.65 (0.18)
    11F/59GBM510 (30)440 (20)840 (130)1.09 (0.26)1.90 (0.22)
    12M/64GBM520 (30)380 (50)710 (110)1.55 (0.38)2.74 (0.34)
    13M/78GBM530 (34)432 (39)725 (165)1.17 (0.25)1.95 (0.17)
    14M/52GBM514 (40)442 (27)675 (162)1.34 (0.18)1.88 (0.23)
    15M/85GBM561 (30)417 (35)845 (167)1.44 (0.26)2.11 (0.28)
    mean (SD)531 (29)409 (38)790 (151)1.36 (0.22)2.45 (0.88)
    • Note:—Min indicates minimum; Max, maximum; AA, anaplastic astrocytoma.

    • ↵a × 10−6 mm2/s; mean (SD) ADC and FDOPA values are given for each patient including for the entire cohort.

    • View popup
    Table 2:

    Tumor volumetric measures

    PatientMax FDOPA Volume (mL)Min ADC Volume (mL)Overlap (%)aOverlap (%)b
    129.929.019.319.9
    238.30.40.219.2
    315.74.80.20.7
    419.90.300
    53.11.600
    618.94.61.04.1
    712.90.40.26.5
    833.90.90.311.3
    921.62.33.028.2
    1060.115.06.827.3
    1144.50.500
    1214.12.90.522.5
    1315.83.70.421.8
    1420.00.40.29.3
    1559.71.90.413.4
    • Note:—Min indicates minimum; Max, maximum.

    • ↵a Overlap (ie, minimum ADC volume overlap with maximum FDOPA SUVR) expressed as a percentage of maximum FDOPA SUVR volume.

    • ↵b Overlap (ie, minimum ADC volume overlap with maximum FDOPA SUVR) expressed as a percentage of mininum ADC volume.

PreviousNext
Back to top

In this issue

American Journal of Neuroradiology: 34 (4)
American Journal of Neuroradiology
Vol. 34, Issue 4
1 Apr 2013
  • Table of Contents
  • Index by author
Advertisement
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on American Journal of Neuroradiology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Correlation of MRI-Derived Apparent Diffusion Coefficients in Newly Diagnosed Gliomas with [18F]-Fluoro-L-Dopa PET: What Are We Really Measuring with Minimum ADC?
(Your Name) has sent you a message from American Journal of Neuroradiology
(Your Name) thought you would like to see the American Journal of Neuroradiology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Cite this article
S. Rose, M. Fay, P. Thomas, P. Bourgeat, N. Dowson, O. Salvado, Y. Gal, A. Coulthard, S. Crozier
Correlation of MRI-Derived Apparent Diffusion Coefficients in Newly Diagnosed Gliomas with [18F]-Fluoro-L-Dopa PET: What Are We Really Measuring with Minimum ADC?
American Journal of Neuroradiology Apr 2013, 34 (4) 758-764; DOI: 10.3174/ajnr.A3315

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
0 Responses
Respond to this article
Share
Bookmark this article
Correlation of MRI-Derived Apparent Diffusion Coefficients in Newly Diagnosed Gliomas with [18F]-Fluoro-L-Dopa PET: What Are We Really Measuring with Minimum ADC?
S. Rose, M. Fay, P. Thomas, P. Bourgeat, N. Dowson, O. Salvado, Y. Gal, A. Coulthard, S. Crozier
American Journal of Neuroradiology Apr 2013, 34 (4) 758-764; DOI: 10.3174/ajnr.A3315
del.icio.us logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Purchase

Jump to section

  • Article
    • Abstract
    • ABBREVIATIONS:
    • Materials and Methods
    • Results
    • Discussion
    • Conclusions
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • Responses
  • References
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • The Role of PET [18F]FDOPA in Evaluating Low-grade Glioma
  • Mean Diffusional Kurtosis in Patients with Glioma: Initial Results with a Fast Imaging Method in a Clinical Setting
  • Crossref (46)
  • Google Scholar

This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.

  • Response Assessment in Neuro-Oncology working group and European Association for Neuro-Oncology recommendations for the clinical use of PET imaging in gliomas
    Nathalie L. Albert, Michael Weller, Bogdana Suchorska, Norbert Galldiks, Riccardo Soffietti, Michelle M. Kim, Christian la Fougère, Whitney Pope, Ian Law, Javier Arbizu, Marc C. Chamberlain, Michael Vogelbaum, Ben M. Ellingson, Joerg C. Tonn
    Neuro-Oncology 2016 18 9
  • Advances in neuro-oncology imaging
    Karl-Josef Langen, Norbert Galldiks, Elke Hattingen, Nadim Jon Shah
    Nature Reviews Neurology 2017 13 5
  • Mean Diffusional Kurtosis in Patients with Glioma: Initial Results with a Fast Imaging Method in a Clinical Setting
    A. Tietze, M.B. Hansen, L. Østergaard, S.N. Jespersen, R. Sangill, T.E. Lund, M. Geneser, M. Hjelm, B. Hansen
    American Journal of Neuroradiology 2015 36 8
  • Brain Tumors: An Update on Clinical PET Research in Gliomas
    Karl Herholz
    Seminars in Nuclear Medicine 2017 47 1
  • Grading and outcome prediction of pediatric diffuse astrocytic tumors with diffusion and arterial spin labeling perfusion MRI in comparison with 18F–DOPA PET
    Giovanni Morana, Arnoldo Piccardo, Domenico Tortora, Matteo Puntoni, Mariasavina Severino, Paolo Nozza, Marcello Ravegnani, Alessandro Consales, Samantha Mascelli, Alessandro Raso, Manlio Cabria, Antonio Verrico, Claudia Milanaccio, Andrea Rossi
    European Journal of Nuclear Medicine and Molecular Imaging 2017 44 12
  • Gradient of Apparent Diffusion Coefficient Values in Peritumoral Edema Helps in Differentiation of Glioblastoma From Solitary Metastatic Lesions
    Pierre Lemercier, Silvia Paz Maya, James T. Patrie, Lucía Flors, Carlos Leiva-Salinas
    American Journal of Roentgenology 2014 203 1
  • Advanced Imaging Techniques for Radiotherapy Planning of Gliomas
    Antonella Castellano, Michele Bailo, Francesco Cicone, Luciano Carideo, Natale Quartuccio, Pietro Mortini, Andrea Falini, Giuseppe Lucio Cascini, Giuseppe Minniti
    Cancers 2021 13 5
  • Combined Amino Acid Positron Emission Tomography and Advanced Magnetic Resonance Imaging in Glioma Patients
    Philipp Lohmann, Jan-Michael Werner, N. Jon Shah, Gereon R. Fink, Karl-Josef Langen, Norbert Galldiks
    Cancers 2019 11 2
  • Multimodal imaging-defined subregions in newly diagnosed glioblastoma: impact on overall survival
    Flóra John, Edit Bosnyák, Natasha L Robinette, Alit J Amit-Yousif, Geoffrey R Barger, Keval D Shah, Sharon K Michelhaugh, Neil V Klinger, Sandeep Mittal, Csaba Juhász
    Neuro-Oncology 2019 21 2
  • Clinical PET/MRI in neurooncology: opportunities and challenges from a single-institution perspective
    Lisbeth Marner, Otto M. Henriksen, Michael Lundemann, Vibeke Andrée Larsen, Ian Law
    Clinical and Translational Imaging 2017 5 2

More in this TOC Section

  • Predictors of Reperfusion in Patients with Acute Ischemic Stroke
  • Enhanced Axonal Metabolism during Early Natalizumab Treatment in Relapsing-Remitting Multiple Sclerosis
  • SWI or T2*: Which MRI Sequence to Use in the Detection of Cerebral Microbleeds? The Karolinska Imaging Dementia Study
Show more BRAIN

Similar Articles

Advertisement

Indexed Content

  • Current Issue
  • Accepted Manuscripts
  • Article Preview
  • Past Issues
  • Editorials
  • Editor's Choice
  • Fellows' Journal Club
  • Letters to the Editor
  • Video Articles

Cases

  • Case Collection
  • Archive - Case of the Week
  • Archive - Case of the Month
  • Archive - Classic Case

More from AJNR

  • Trainee Corner
  • Imaging Protocols
  • MRI Safety Corner
  • Book Reviews

Multimedia

  • AJNR Podcasts
  • AJNR Scantastics

Resources

  • Turnaround Time
  • Submit a Manuscript
  • Submit a Video Article
  • Submit an eLetter to the Editor/Response
  • Manuscript Submission Guidelines
  • Statistical Tips
  • Fast Publishing of Accepted Manuscripts
  • Graphical Abstract Preparation
  • Imaging Protocol Submission
  • Evidence-Based Medicine Level Guide
  • Publishing Checklists
  • Author Policies
  • Become a Reviewer/Academy of Reviewers
  • News and Updates

About Us

  • About AJNR
  • Editorial Board
  • Editorial Board Alumni
  • Alerts
  • Permissions
  • Not an AJNR Subscriber? Join Now
  • Advertise with Us
  • Librarian Resources
  • Feedback
  • Terms and Conditions
  • AJNR Editorial Board Alumni

American Society of Neuroradiology

  • Not an ASNR Member? Join Now

© 2025 by the American Society of Neuroradiology All rights, including for text and data mining, AI training, and similar technologies, are reserved.
Print ISSN: 0195-6108 Online ISSN: 1936-959X

Powered by HighWire