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AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticleNeurointervention

Stent-Assisted Coiling of Bifurcation Aneurysms May Improve Endovascular Treatment: A Critical Evaluation in an Experimental Model

J. Raymond, T.E. Darsaut, F. Bing, A. Makoyeva, M. Kotowski, G. Gevry and I. Salazkin
American Journal of Neuroradiology March 2013, 34 (3) 570-576; DOI: https://doi.org/10.3174/ajnr.A3231
J. Raymond
aFrom the Department of Radiology (J.R., T.E.D., A.M., G.G., I.S.), Centre Hospitalier de l'Université de Montréal, Notre-Dame Hospital, Montreal, Quebec, Canada
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T.E. Darsaut
aFrom the Department of Radiology (J.R., T.E.D., A.M., G.G., I.S.), Centre Hospitalier de l'Université de Montréal, Notre-Dame Hospital, Montreal, Quebec, Canada
bDivision of Neurosurgery, Department of Surgery (T.E.D.), Mackenzie Health Sciences Centre, University of Alberta Hospital, Edmonton, Alberta, Canada
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F. Bing
cService de Radiologie A (F.B.), Centre Hospitalier Universitaire Strasbourg, Université Strasbourg 1, Hôpital Civil, Strasbourg, France
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A. Makoyeva
aFrom the Department of Radiology (J.R., T.E.D., A.M., G.G., I.S.), Centre Hospitalier de l'Université de Montréal, Notre-Dame Hospital, Montreal, Quebec, Canada
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M. Kotowski
dDepartment of Neurosurgery (M.K.), Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.
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G. Gevry
aFrom the Department of Radiology (J.R., T.E.D., A.M., G.G., I.S.), Centre Hospitalier de l'Université de Montréal, Notre-Dame Hospital, Montreal, Quebec, Canada
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I. Salazkin
aFrom the Department of Radiology (J.R., T.E.D., A.M., G.G., I.S.), Centre Hospitalier de l'Université de Montréal, Notre-Dame Hospital, Montreal, Quebec, Canada
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  • Fig. 1.
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    Fig. 1.

    Bench studies. The experimental setup testing stent 1 is shown in A and B and stent 2 is shown in C and D. Note the relatively unchanged transition Zone2 compared with the compaction Zone3 that decreases in porosity with stent compaction. The Y construction is shown in E, with compaction of stent 2 in F, still leaving high-porosity Zone2. In vivo images of corresponding stent configurations are shown in G, H, and I. Neointima formed only on low-porosity zones.

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    Fig. 2.

    Surgical construction of aneurysms. The dysplastic bifurcation is constructed by creating a front and a back flap (A). Points AF are sutured together at the back, while the front flap is closed by suturing point C to AF and D to D′, resulting in a wide-neck bifurcation aneurysm (B). An example is shown at angiography in C.

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    Fig. 3.

    Stent compaction and porosity. In vitro studies showing the effects of stent compaction on different segments or zones of stents when extremities are inserted in 2-mm tubes. Effects on stent 1 are shown in A, on stent 2 in B. While the porosity of Zone3 can be significantly decreased with stent compaction, the transition Zone2 remains relatively unchanged.

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    Fig. 4.

    Endovascular treatment groups. Selected frames of angiographic series showing aneurysms before (A,E,I,M), immediately after (B,F,J,N), and 3 months after treatment (C,G,K,O), and photographs of the aneurysm ostium (D,H,L,P) in animals treated by coiling (A–D), single stent–assisted coiling (E–H), Y-stent-assisted coiling (I–L), and Y-stenting (M–P) showing recurring aneurysm with simple coiling (asterisk in C), better results with stent-assisted coiling, and the absence of therapeutic effect with Y-stenting only (asterisk in O). N was taken at the end of the angiographic series, to show the Y disposition of stents.

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    Fig. 5.

    Neointimal closure of aneurysm necks. Photographs of specimens 3 months after coiling (A), single stent–assisted coiling (B), Y-stent-assisted coiling (C), and Y-stent placement only (D), showing how neointima formed mainly on coil loops. Bare stent struts are shown by arrows in B and C. Note widely open pores in transition zone2 after Y-stent placement only (arrows in D).

Tables

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  • Aneurysm dimensions and results of endovascular treatments

    GroupsAneurysm ParametersCoil Volume (mm3)Packing Density (%)Median Scores
    Long Axis (mm)Short Axis (mm)Neck (mm)Volume (mm3)Initial3 MonthsNeointima
    Coils only (n = 6)15.2 ± 1.07.3 ± 0.57.5 ± 0.8655 ± 62170 ± 4925.9 ± 6.2122
    1 stent + coils (n = 5)17.2 ± 2.88.0 ± 2.08.8 ± 1.9991 ± 603136 ± 4316.9 ± 7.70a0a2
    2 stents + coils (n = 5)13.6 ± 3.67.0 ± 0.76.6 ± 1.1548 ± 312115 ± 3024.0 ± 7.7112
    2 stents (n = 4)16.8 ± 1.06.8 ± 0.18.5 ± 0.6699 ± 140234b
    Controls (n = 4)16.0 ± 5.510.8 ± 1.38.4 ± 1.01053 ± 54723
    • Note:—Values are reported as mean ± SD.

    • ↵a Stent-assisted coiling led to more complete occlusions initially (P = .013) and at 3 months (P = .010) than coiling alone.

    • ↵b Aneurysms treated with Y-stenting only had significantly worse neointimal results than all other groups (P = .023).

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American Journal of Neuroradiology: 34 (3)
American Journal of Neuroradiology
Vol. 34, Issue 3
1 Mar 2013
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Cite this article
J. Raymond, T.E. Darsaut, F. Bing, A. Makoyeva, M. Kotowski, G. Gevry, I. Salazkin
Stent-Assisted Coiling of Bifurcation Aneurysms May Improve Endovascular Treatment: A Critical Evaluation in an Experimental Model
American Journal of Neuroradiology Mar 2013, 34 (3) 570-576; DOI: 10.3174/ajnr.A3231

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Stent-Assisted Coiling of Bifurcation Aneurysms May Improve Endovascular Treatment: A Critical Evaluation in an Experimental Model
J. Raymond, T.E. Darsaut, F. Bing, A. Makoyeva, M. Kotowski, G. Gevry, I. Salazkin
American Journal of Neuroradiology Mar 2013, 34 (3) 570-576; DOI: 10.3174/ajnr.A3231
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