Article Figures & Data
Figures
- Fig 1.
MR images of the globe reformatted in sagittal (A) and axial (B) planes. The coordinate system is defined by the center of mass of the lens and the globe (red and green points), respectively. The red contour marks the posterior sclera. Each point on the sclera is defined by the distance to the center of the orbit (dashed line), azimuth angle (θ), and the elevation angle (ϕ).
- Fig 2.
A 2D color-coded distance map visualizes distances between the center of the globe and points on the posterior sclera. The map represents the globe shown in Fig 1. The inward protrusion of the papilla is visualized as an off-center blue patch (A). The central (red) and peripheral (yellow) ROIs used for the derivation of NP and GF are shown in B and C, respectively. The angular boundaries of the central (papillar), peripappilar, and peripheral ROIs are 0–10°, 10–18°, and 40–80°, respectively.
- Fig 3.
Reformatted MR images shown in axial plane for a normal globe (A), a flattened globe with minimal optic nerve protrusion (B), and a globe with minimal flattening and extensive optic nerve protrusion (C). Respective distance maps are shown in the bottom. The corresponding GF and NP values are (A) 0.97 and 0.97, (B) 0.86 and 0.91, and (C) 0.91 and 0.88.
- Fig 4.
Average left and right eyes, 2D-distance maps obtained from the control cohort (upper row) and the IIH cohort (lower row). The presence of nerve protrusion is clearly seen in the maps from the IIH cohort.
- Fig 5.
Pretreatment (upper row) and posttreatment (lower row) average distance maps of the patients with IIH who had a follow-up MR imaging scan (n = 4). A significant reversal of the extent of the optic nerve protrusion is visualized in the posttreatment maps.
- Fig 6.
Scatterplots of the relationships between GF and intraocular pressure (A) and between MD and CSF opening pressure (B).
Tables
Measure Control (n = 7) IIH (n = 6) P Value NP 0.96 ± 0.013 0.91 ± 0.028 .00002 GF 0.93 ± 0.020 0.91 ± 0.022 .0035 MD 0.93 ± 0.021 0.88 ± 0.027 .00002 - Table 2:
Pretreatment and posttreatment mean values of deformation measures in the IIH subcohort
Measure IIH Pre (n = 4) IIH Post (n = 4) P Value NP 0.91 ± 0.032 0.94 ± 0.017 .036 GF 0.90 ± 0.021 0.92 ± 0.023 .09 MD 0.88 ± 0.024 0.91 ± 0.024 .011
