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AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticleNeurointervention
Open Access

Reduced Mortality and Severe Disability Rates in the SENTIS Trial

P.D. Schellinger, A. Shuaib, M. Köhrmann, D.S. Liebeskind, T. Jovin, M.D. Hammer, S. Sen, D.Y. Huang, S. Solander, R. Gupta, R.R. Leker and J.L. Saver for the SENTIS Trial Investigators
American Journal of Neuroradiology December 2013, 34 (12) 2312-2316; DOI: https://doi.org/10.3174/ajnr.A3613
P.D. Schellinger
aFrom JW Klinikum (P.D.S.), Minden, Germany
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A. Shuaib
bUniversity of Alberta (A.S.), Edmonton, Alberta, Canada
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M. Köhrmann
cUniversitätsklinikum Erlangen (M.K.), Erlangen, Germany
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D.S. Liebeskind
dUniversity of California, Los Angeles (D.S.L., J.L.S.), Los Angeles, California
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T. Jovin
eUniversity of Pittsburgh Medical Center (T.J., M.D.H.), Pittsburgh, Pennsylvania
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M.D. Hammer
eUniversity of Pittsburgh Medical Center (T.J., M.D.H.), Pittsburgh, Pennsylvania
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S. Sen
fSt Thomas Hospital (S.Sen), Nashville, Tennessee
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D.Y. Huang
gUniversity of South Carolina (D.Y.H.), Columbia, South Carolina
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S. Solander
hUniversity of North Carolina (S.Solander), Chapel Hill, North Carolina
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R. Gupta
iEmory University (R.G.), Atlanta, Georgia
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R.R. Leker
jHadassah Hebrew University Medical Center (R.R.L.), Jerusalem, Israel.
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J.L. Saver
dUniversity of California, Los Angeles (D.S.L., J.L.S.), Los Angeles, California
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    Fig 1.

    Kaplan-Meier curve: Freedom from stroke-related mortality.

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    Fig 2.

    Modified Rankin shift for SENTIS as-treated population. *Values within the shift analysis are based on 90-day evaluable patients.

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    Table 1:

    First site of care

    First Site of CareTreatedNot TreatedP Value (Fisher Exact)
    N = 204N = 233
    n = 25n = 38
    Neuro/Stroke ICU40.2% (82/204)32.2% (75/233).090
    Other ICU20.1% (41/204)14.6% (34/233).162
    Stroke unit33.3% (68/204)38.6% (90/233).273
    General unit6.4% (13/204)14.6% (34/233).008
    Any ICUa60.3% (123/204)46.8% (109/233).005
    • Note:—N indicates total number of surveys received with evaluable data for first site of care; n, number of patients with evaluable surveys who died.

    • ↵a Any ICU is the combination of the Neuro/Stroke ICU and Other ICU.

    • View popup
    Table 2:

    All-cause mortality rate by first site of care

    First Site of CareTreatedNot TreatedP Value (Fisher Exact)
    N = 204N = 233
    n = 25n = 38
    Neuro/Stroke ICU8.5% (7/82)16.0% (12/75).220
    Other ICU14.6% (6/41)17.7% (6/34).760
    Stroke unit13.2% (9/68)14.4% (13/90)1.000
    General unit23.1% (3/13)20.6% (7/34)1.000
    Total mortality rate12.3%16.3%.275
    • Note:—N indicates total number of surveys received with evaluable data for first site of care; n, number of patients with evaluable surveys who died.

    • View popup
    Table 3:

    Stroke-related mortality rate by first site of care

    First Site of CareTreatedNot TreatedP Value (Fisher Exact)
    N = 204N = 233
    n = 17n = 33
    Neuro/Stroke ICU7.3% (6/82)16.0% (12/75).131
    Other ICU7.3% (3/41)17.7% (6/34).285
    Stroke unit8.8% (6/68)11.1% (10/90).792
    General unit15.4% (2/13)14.7% (5/34)1.000
    Total stroke-related mortality rate8.3%14.2%.070
    • Note:—N indicates total number of surveys received with evaluable data for first site of care; n, number of patients with evaluable surveys who died of stroke-related causes.

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American Journal of Neuroradiology: 34 (12)
American Journal of Neuroradiology
Vol. 34, Issue 12
1 Dec 2013
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Cite this article
P.D. Schellinger, A. Shuaib, M. Köhrmann, D.S. Liebeskind, T. Jovin, M.D. Hammer, S. Sen, D.Y. Huang, S. Solander, R. Gupta, R.R. Leker, J.L. Saver
Reduced Mortality and Severe Disability Rates in the SENTIS Trial
American Journal of Neuroradiology Dec 2013, 34 (12) 2312-2316; DOI: 10.3174/ajnr.A3613

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Reduced Mortality and Severe Disability Rates in the SENTIS Trial
P.D. Schellinger, A. Shuaib, M. Köhrmann, D.S. Liebeskind, T. Jovin, M.D. Hammer, S. Sen, D.Y. Huang, S. Solander, R. Gupta, R.R. Leker, J.L. Saver
American Journal of Neuroradiology Dec 2013, 34 (12) 2312-2316; DOI: 10.3174/ajnr.A3613
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