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Research ArticleBrain
Open Access

Thalamic Projection Fiber Integrity in de novo Parkinson Disease

P.J. Planetta, E.T. Schulze, E.K. Geary, D.M. Corcos, J.G. Goldman, D.M. Little and D.E. Vaillancourt
American Journal of Neuroradiology January 2013, 34 (1) 74-79; DOI: https://doi.org/10.3174/ajnr.A3178
P.J. Planetta
aFrom the Departments of Applied Physiology and Kinesiology (P.J.P., D.E.V.)
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E.T. Schulze
dDepartments of Neurology and Rehabilitation (E.T.S., E.K.G., D.M.C.)
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E.K. Geary
dDepartments of Neurology and Rehabilitation (E.T.S., E.K.G., D.M.C.)
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D.M. Corcos
dDepartments of Neurology and Rehabilitation (E.T.S., E.K.G., D.M.C.)
eKinesiology and Nutrition (D.M.C.)
fPhysical Therapy (D.M.C.)
gBioengineering (D.M.C.), University of Illinois at Chicago, Chicago, Illinois
hDepartment of Neurological Sciences (D.M.C., J.G.G.), Rush University Medical Center, Chicago, Illinois
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J.G. Goldman
hDepartment of Neurological Sciences (D.M.C., J.G.G.), Rush University Medical Center, Chicago, Illinois
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D.M. Little
iDepartment of Veterans Affairs, VISN 17 Center of Excellence for Research on Returning War Veterans (D.M.L.), Waco, Texas
jDepartment of Psychiatry and Behavioral Science (D.M.L.), Texas A&M Health Sciences Center, Bryan, Texas.
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D.E. Vaillancourt
aFrom the Departments of Applied Physiology and Kinesiology (P.J.P., D.E.V.)
bNeurology (D.E.V.)
cBiomedical Engineering (D.E.V.), University of Florida, Gainesville, Florida
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    Fig 1.

    FA image from a representative healthy control subject showing (A) regional boundaries of the 6 thalamic regions in which the circular ROIs were placed, and (B) fiber tracking from the ROIs in each thalamic region.

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    Fig 2.

    Mean (± SEM) FA values from each of the 6 thalamic regions for the control and PD groups. Note that the PD group has significantly reduced of FA values compared with the control group in the AN, VA, and DM, and shows a marginally significant reduction in the VL.

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American Journal of Neuroradiology: 34 (1)
American Journal of Neuroradiology
Vol. 34, Issue 1
1 Jan 2013
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P.J. Planetta, E.T. Schulze, E.K. Geary, D.M. Corcos, J.G. Goldman, D.M. Little, D.E. Vaillancourt
Thalamic Projection Fiber Integrity in de novo Parkinson Disease
American Journal of Neuroradiology Jan 2013, 34 (1) 74-79; DOI: 10.3174/ajnr.A3178

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Thalamic Projection Fiber Integrity in de novo Parkinson Disease
P.J. Planetta, E.T. Schulze, E.K. Geary, D.M. Corcos, J.G. Goldman, D.M. Little, D.E. Vaillancourt
American Journal of Neuroradiology Jan 2013, 34 (1) 74-79; DOI: 10.3174/ajnr.A3178
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  • Substantia Nigra Free Water Increases Longitudinally in Parkinson Disease
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    American Journal of Neuroradiology 2018 39 3
  • Basal ganglia and cerebellar interconnectivity within the human thalamus
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