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Research ArticleBrainE
Open Access

Differentiation of Pyogenic Brain Abscesses from Necrotic Glioblastomas with Use of Susceptibility-Weighted Imaging

C.H. Toh, K.-C. Wei, C.-N. Chang, P.-W. Hsu, H.-F. Wong, S.-H. Ng, M. Castillo and C.-P. Lin
American Journal of Neuroradiology September 2012, 33 (8) 1534-1538; DOI: https://doi.org/10.3174/ajnr.A2986
C.H. Toh
aFrom the Departments of Medical Imaging and Intervention (C.H.T., H.-F.W., S.-H.N.)
cDepartment of Biomedical Imaging and Radiological Sciences (C.H.T., C.-P.L.)
dBrain Connectivity Laboratory (C.H.T., C.-P.L.), Institute of Neuroscience, National Yang-Ming University, Taipei, Taiwan
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K.-C. Wei
bNeurosurgery (K.-C.W., C.-N.C., P.-W.H.), Chang Gung Memorial Hospital, Linkou and Chang Gung University College of Medicine, Tao-Yuan, Taiwan
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C.-N. Chang
bNeurosurgery (K.-C.W., C.-N.C., P.-W.H.), Chang Gung Memorial Hospital, Linkou and Chang Gung University College of Medicine, Tao-Yuan, Taiwan
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P.-W. Hsu
bNeurosurgery (K.-C.W., C.-N.C., P.-W.H.), Chang Gung Memorial Hospital, Linkou and Chang Gung University College of Medicine, Tao-Yuan, Taiwan
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H.-F. Wong
aFrom the Departments of Medical Imaging and Intervention (C.H.T., H.-F.W., S.-H.N.)
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S.-H. Ng
aFrom the Departments of Medical Imaging and Intervention (C.H.T., H.-F.W., S.-H.N.)
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M. Castillo
eDepartment of Radiology (M.C.), University of North Carolina School of Medicine, Chapel Hill, North Carolina.
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C.-P. Lin
cDepartment of Biomedical Imaging and Radiological Sciences (C.H.T., C.-P.L.)
dBrain Connectivity Laboratory (C.H.T., C.-P.L.), Institute of Neuroscience, National Yang-Ming University, Taipei, Taiwan
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    Fig 1.

    A 56-year-old woman with 2 right occipital pyogenic brain abscesses. A, Transverse contrast-enhanced MPRAGE shows 2 adjoining rim-enhancing masses in the right occipital lobe. B, On the transverse T2-weighted image, an incomplete hypointense rim (arrow) is present at the lesion margin. C, On transverse SWI, the abscesses are bordered by 2 concentric rims, with the outer one being hypointense (arrow), and the inner one, hyperintense (arrowhead) relative to cavity content, forming the dual rim sign. D, On the close-up view of the SWI with the contrast-enhancing rim (red region of interest) overlaid, the hyperintense rim (arrowhead) is inner to the contrast-enhancing rim.

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    Fig 2.

    A 57-year-old man with a right temporal necrotic glioblastoma. A, Transverse contrast-enhanced MPRAGE shows a rim-enhancing mass in the right temporal lobe. B, On the transverse T2-weighted image, the hypointense rim is absent. C, On the transverse SWI, abundant hypointensities (arrows) with an irregular contour forming an incomplete rim are present at the lesion margin. D, On the close-up view of SWI with a contrast-enhancing rim (red region of interest) overlaid, some of these hypointensities (arrows) are inner to the contrast-enhancing rim, while some are overlapping the contrast-enhancing rim.

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    Fig 3.

    A 40-year-old woman with a left temporal necrotic glioblastoma. A, Transverse contrast-enhanced MPRAGE shows a rim-enhancing mass in the left temporal lobe. The hypointense rim is absent on both transverse T2W (B) and SW (C) images.

Tables

  • Figures
  • Comparisons of the imaging features of the lesion margins on SWI between abscesses and glioblastomas

    FeaturesAbscessGBP ValueSENSPEAccuracyPPVNPV
    Hypointense rim
        Prevalence0.059
            Absent05
            Present1215
        Border<.00191.786.788.984.692.9
            Incomplete113
            Completea112
        Contour<.00175.086.781.581.881.3
            Smootha92
            Irregular313
        Locationb<.00191.786.788.984.692.9
            Inner09
            Samea112
            Inner + Same14
    Dual rim sign<.00175.010090.610087.0
            Absent320
            Presenta90
    • Note:—GB indicates glioblastoma; SEN, sensitivity; SPE, specificity; PPV, positive predictive value; NPV, negative predictive value.

    • ↵a Imaging features selected for the calculation of SEN, SPE, PPV, and NPV.

    • ↵b Relative to the contrast-enhancing rims.

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American Journal of Neuroradiology: 33 (8)
American Journal of Neuroradiology
Vol. 33, Issue 8
1 Sep 2012
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Cite this article
C.H. Toh, K.-C. Wei, C.-N. Chang, P.-W. Hsu, H.-F. Wong, S.-H. Ng, M. Castillo, C.-P. Lin
Differentiation of Pyogenic Brain Abscesses from Necrotic Glioblastomas with Use of Susceptibility-Weighted Imaging
American Journal of Neuroradiology Sep 2012, 33 (8) 1534-1538; DOI: 10.3174/ajnr.A2986

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Differentiation of Pyogenic Brain Abscesses from Necrotic Glioblastomas with Use of Susceptibility-Weighted Imaging
C.H. Toh, K.-C. Wei, C.-N. Chang, P.-W. Hsu, H.-F. Wong, S.-H. Ng, M. Castillo, C.-P. Lin
American Journal of Neuroradiology Sep 2012, 33 (8) 1534-1538; DOI: 10.3174/ajnr.A2986
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