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AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticleNeurointervention

Reperfusion Rates Following Intra-Arterial Thrombolysis for Acute Ischemic Stroke: The Influence of the Method for Alteplase Delivery

G.A. Christoforidis, A. Slivka, Y. Mohammad, C. Karakasis, M. Kontzialis and M. Khadir
American Journal of Neuroradiology August 2012, 33 (7) 1292-1298; DOI: https://doi.org/10.3174/ajnr.A2973
G.A. Christoforidis
aFrom the Department of Radiology (G.A.C., M.Khadir.), University of Chicago Medical Center, Chicago, Illinois
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A. Slivka
bDepartments of Neurology (A.S., Y.M.)
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Y. Mohammad
bDepartments of Neurology (A.S., Y.M.)
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C. Karakasis
cRadiology (C.K., M.Kontzialis.), The Ohio State University Medical Center, Columbus, Ohio.
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M. Kontzialis
cRadiology (C.K., M.Kontzialis.), The Ohio State University Medical Center, Columbus, Ohio.
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M. Khadir
aFrom the Department of Radiology (G.A.C., M.Khadir.), University of Chicago Medical Center, Chicago, Illinois
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References

  1. 1.↵
    1. Fischer S,
    2. Kohnert U.
    . Major mechanistic differences explain the higher clot lysis potency of reteplase over alteplase: lack of fibrin binding is an advantage for bolus application of fibrin-specific thrombolytics. Fibrinolysis and Proteolysis 1997;11:129–35
  2. 2.↵
    1. Christoforidis GA,
    2. Mohammad Y,
    3. Avutu B,
    4. et al
    . Arteriographic demonstration of slow antegrade opacification distal to a cerebrovascular thromboembolic occlusion site as a favorable indicator for intra-arterial thrombolysis. AJNR Am J Neuroradiol 2006;27:1528–31
    Abstract/FREE Full Text
  3. 3.↵
    1. Furlan A,
    2. Higashida R,
    3. Weschler L,
    4. et al
    . Intra-arterial Prourokinase for Acute Ischemic Stroke: the PROACT II Study. JAMA 1999;282:2003–11
    CrossRefPubMedWeb of Science
  4. 4.↵
    1. Del Zoppo G,
    2. Higashida R,
    3. Furlan A,
    4. et al
    . PROACT: a phase II randomized trial of recombinant pro-urokinase by direct arterial delivery in acute middle cerebral artery stroke—PROACT Investigators. Prolyse in Acute Cerebral Thromboembolism. Stroke 1998;29:4–11
    Abstract/FREE Full Text
  5. 5.↵
    1. Christoforidis GA,
    2. Slivka A,
    3. Mohammad Y,
    4. et al
    . Size matters: hemorrhage volume as an objective measure to define significant intracranial hemorrhage associated with thrombolysis. Stroke 2007;38:1799–804
    Abstract/FREE Full Text
  6. 6.↵
    1. Khatri P,
    2. Neff J,
    3. Broderick JP,
    4. et al.
    , for the IMS-I Investigators. Revascularization end points in stroke interventional trials: recanalization versus reperfusion in IMS-I. Stroke 2005;35:2400–03. Epub 2005 Oct 13
  7. 7.↵
    1. Christoforidis GA,
    2. Mohammad Y,
    3. Kehagias D,
    4. et al
    . Angiographic assessment of pial collaterals as a prognostic indicator following intra-arterial thrombolysis for acute ischemic stroke. AJNR Am J Neuroradiol 2005;26:1789–97
    Abstract/FREE Full Text
  8. 8.↵
    1. Higashida RT,
    2. Furlan AJ
    . Trial design and reporting standards for intra-arterial cerebral thrombolysis for acute ischemic stroke. Stroke 2003;34:109–37
    CrossRef
  9. 9.↵
    1. Kurosawa Y,
    2. Lu A,
    3. Khatri P,
    4. et al
    . Intra-arterial iodinated radiographic contrast material injection administration in a rat middle cerebral artery occlusion and reperfusion model: possible effects on intracerebral hemorrhage. Stroke 2010;41:1013–17
    Abstract/FREE Full Text
  10. 10.↵
    1. Qureshi AI,
    2. Siddiqui AM,
    3. Suri MF,
    4. et al
    . Aggressive mechanical clot disruption and low-dose intra-arterial third-generation thrombolytic agent for ischemic stroke: a prospective study. Neurosurgery 2002;51:1319–29
    CrossRefPubMedWeb of Science
  11. 11.↵
    1. Sorimachi T,
    2. Fujii Y,
    3. Tsuchiya N,
    4. et al
    . Recanalization by mechanical embolus disruption during intra-arterial thrombolysis in the carotid territory. AJNR Am J Neuroradiol 2004;25:1391–402
    Abstract/FREE Full Text
  12. 12.↵
    1. Noser EA,
    2. Shaltoni HM,
    3. Hall CE,
    4. et al
    . Aggressive mechanical clot disruption: a safe adjunct to thrombolytic therapy in acute stroke? Stroke 2005;36:292–96
    Abstract/FREE Full Text
  13. 13.↵
    1. Dong JK,
    2. Dong IK,
    3. Joon SB,
    4. et al
    . Simple microwire and microcatheter mechanical thrombolysis with adjuvant intraarterial urokinase for treatment of hyperacute ischemic stroke patients. Acta Radiol 2008;49:351–57
    FREE Full Text
  14. 14.↵
    1. Khatri P,
    2. Wechsler LR,
    3. Broderick JP
    . Intracranial hemorrhage associated with revascularization therapies. Stroke 2007;38:431–40
    Abstract/FREE Full Text
  15. 15.↵
    1. Yoon W,
    2. Seo JJ,
    3. Kim JK,
    4. et al
    . Contrast enhancement and contrast extravasation on computed tomography after intra-arterial thrombolysis in patients with acute ischemic stroke. Stroke 2004;35:876–81
    Abstract/FREE Full Text
  16. 16.↵
    1. Nguyen TN,
    2. Lanthier S,
    3. Roy D
    . Iatrogenic arterial perforation during acute stroke interventions. AJNR Am J Neuroradiol 2008;29:974–75
    Abstract/FREE Full Text
  17. 17.↵
    1. Pillai JJ,
    2. Lanzieri CF,
    3. Trinidad SB,
    4. et al
    . Initial angiographic appearance of intracranial vascular occlusions in acute stroke as a predictor of outcome of thrombolysis: initial experience. Radiology 2001;218:733–38
    PubMed
  18. 18.↵
    1. Tomsick T
    . TIMI, TIBI, TICI: I came, I saw, I got confused. AJNR Am J Neuroradiol 2007;28:382–84
    FREE Full Text
  19. 19.↵
    IMS Study Investigators. Combined intravenous and intra-arterial recanalization for acute ischemic stroke: the Interventional Management of Stroke Study. Stroke 2004;35:904–11. Epub 2004 Mar 11
    Abstract/FREE Full Text
  20. 20.↵
    1. Smith WS,
    2. Sung G,
    3. Saver J,
    4. et al.
    , for the Multi MERCI Investigators. Mechanical thrombectomy for acute ischemic stroke: final results of the Multi MERCI trial. Stroke 2008;39:1205–12
    Abstract/FREE Full Text
  21. 21.↵
    The Penumbra Pivotal Stroke Trial Investigators. The Penumbra Pivotal Stroke Trial: safety and effectiveness of a new generation of mechanical devices for clot removal in intracranial large vessel occlusive disease. Stroke 2009;40:2761–68. Epub 2009 Jul 9
    Abstract/FREE Full Text
  22. 22.↵
    1. Christoforidis GA,
    2. Slivka AP,
    3. Karakasis C,
    4. et al
    . Hemorrhage rates and outcomes when using up to 100 mg intra-arterial tPA for thrombolysis in acute ischemic stroke. Interv Neuroradiol 2010;16:297–305. Epub 2010 Oct 25
    Abstract/FREE Full Text
  23. 23.↵
    1. Christoforidis GA,
    2. Karakasis C,
    3. Mohammad YM,
    4. et al
    . Predictors of hemorrhage following intra-arterial thrombolysis for acute ischemic stroke: the role of pial collateral formation. AJNR Am J Neuroradiol 2009;30:165–70
    Abstract/FREE Full Text
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American Journal of Neuroradiology: 33 (7)
American Journal of Neuroradiology
Vol. 33, Issue 7
1 Aug 2012
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G.A. Christoforidis, A. Slivka, Y. Mohammad, C. Karakasis, M. Kontzialis, M. Khadir
Reperfusion Rates Following Intra-Arterial Thrombolysis for Acute Ischemic Stroke: The Influence of the Method for Alteplase Delivery
American Journal of Neuroradiology Aug 2012, 33 (7) 1292-1298; DOI: 10.3174/ajnr.A2973

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Reperfusion Rates Following Intra-Arterial Thrombolysis for Acute Ischemic Stroke: The Influence of the Method for Alteplase Delivery
G.A. Christoforidis, A. Slivka, Y. Mohammad, C. Karakasis, M. Kontzialis, M. Khadir
American Journal of Neuroradiology Aug 2012, 33 (7) 1292-1298; DOI: 10.3174/ajnr.A2973
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This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.

  • Adjuvant intra-arterial thrombolysis during mechanical thrombectomy is an effective means of improving outcomes for patients with large vessel occlusion stroke: A systematic review and meta-analysis
    Yu Chang, Yi-Zheng Li, Lin Xue
    Clinical Neurology and Neurosurgery 2023 232

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