Sensorimotor, Visual, and Auditory Cortical Atrophy in Unverricht-Lundborg Disease Mapped with Cortical Thickness Analysis

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Fig 1.
Group analysis of CTH. Brain regions demonstrate significantly (P < .0001, FDR corrected) reduced CTH in patients with EPM1 compared with healthy controls.
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Fig 2.
Brain regions with significant (P < .01, FDR-corrected) negative correlations between age and CTH in patients with EPM1 (A) and controls (B). Scatterplots indicate correlations between age and mean CTH in individual subjects. The individual mean thicknesses have been calculated on the basis of the regions surviving the statistical threshold.
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Fig 3.
Brain regions with significant (P < .05, FDR-corrected) negative correlations between the “Myoclonus with Action” score and CTH in patients with EPM1. Scatterplots indicate correlations between the “Myoclonus with Action” score and mean CTH in individual subjects. The individual mean thicknesses have been calculated on the basis of the regions surviving the statistical threshold.

Table 1:

Basic clinical characteristics and demographics of 53 patients with EPM1 and 70 controls^a)

Table 2:

Areas of significant difference in CTH between the EPM1 group and controls

Brain Region	Hemisphere	Maximum T Value	MNI Coordinates, (x, y, z)^a
Central sulcus	Right	8.42	42, −16, 36
	Left	6.69	−39, −19, 46
Precentral sulcus	Left	6.05	−40, 7, 27
Paracentral lobule	Right	8.11	5, −27, 50
Postcentral gyrus	Right	7.32	6, −49, 65
Cingulate sulcus	Left	8.06	−10, −19, 46
Postcentral sulcus	Left	6.79	−24, −40, 60
Superior frontal gyrus	Right	6.48	7, 45, 29
Calcarine sulcus	Left	8.99	−20, −70, 6
Lingual gyrus	Right	6.52	5, −68, 3
	Left	8.20	−3, −76, 5
Superior temporal sulcus	Right	5.32	54, −16, −14
Transverse temporal gyrus	Right	5.33	43, −28, 10
Middle temporal gyrus	Left	5.98	−48, −66, 4
Inferior occipital gyrus	Left	7.39	−27, −89, −17

Note:—MNI indicates Montreal Neurological Institute.
↵a MNI coordinates are based on a standard brain template defined by using multiple MR images of healthy controls.