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Research ArticleBrain
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A Validation Study of Multicenter Diffusion Tensor Imaging: Reliability of Fractional Anisotropy and Diffusivity Values

R.J. Fox, K. Sakaie, J.-C. Lee, J.P. Debbins, Y. Liu, D.L. Arnold, E.R. Melhem, C.H. Smith, M.D. Philips, M. Lowe and E. Fisher
American Journal of Neuroradiology April 2012, 33 (4) 695-700; DOI: https://doi.org/10.3174/ajnr.A2844
R.J. Fox
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K. Sakaie
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J.-C. Lee
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J.P. Debbins
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Y. Liu
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D.L. Arnold
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E.R. Melhem
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C.H. Smith
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M.D. Philips
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M. Lowe
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E. Fisher
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    Fig 1.

    White and gray matter ROIs used for calculating DTI metrics in a single subject. Similar ROIs were used in the second subject. A, Anterior and posterior corpus callosum (red). B–D, Deep white matter (left and right occipital, frontal, and parietal, respectively; blue). E, Left and right periventricular white matter (green). F, Left and right cortical gray matter (gray). G and H, Left and right deep gray matter (putamen, white).

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    Fig 2.

    Mean DTI measures for different brain regions from each of the 5 magnets. Error bars are SDs.

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    Table 1:

    Mean concordance coefficients of DTI measuresa

    Type of ConcordanceFAλ‖λ⊥ADC
    Overall mean concordance0.960.930.930.88
    Cross-platform mean concordance0.960.920.910.86
    Siemens mean concordance0.960.930.930.89
    GE correlation (1 comparison only)0.970.940.940.90
    Longitudinal mean concordance0.960.960.970.96
    Across-system upgrade0.950.960.970.96
    After system upgrade0.970.950.970.96
    • ↵a Average Lin's concordance coefficients comparing different imaging conditions across all regions from both subjects. Each value represents the mean of the different between-magnet concordance coefficients.

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    Table 2:

    Mean CVs across ROIs

    Scanner ComparisonCV across ROIsFAλ‖λ⊥ADC
    Across 5 scannersOverall CV (%), white matter only CV (%)9.15.06.64.8
    6.84.34.34.1
    Same scanner with time Overall CV (%), white matter only CV (%)9.63.74.22.2
    8.73.54.62.2
    • Average CV averaged across ROIs for the 5 different scanners and within a single scanner with time.

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American Journal of Neuroradiology: 33 (4)
American Journal of Neuroradiology
Vol. 33, Issue 4
1 Apr 2012
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R.J. Fox, K. Sakaie, J.-C. Lee, J.P. Debbins, Y. Liu, D.L. Arnold, E.R. Melhem, C.H. Smith, M.D. Philips, M. Lowe, E. Fisher
A Validation Study of Multicenter Diffusion Tensor Imaging: Reliability of Fractional Anisotropy and Diffusivity Values
American Journal of Neuroradiology Apr 2012, 33 (4) 695-700; DOI: 10.3174/ajnr.A2844

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A Validation Study of Multicenter Diffusion Tensor Imaging: Reliability of Fractional Anisotropy and Diffusivity Values
R.J. Fox, K. Sakaie, J.-C. Lee, J.P. Debbins, Y. Liu, D.L. Arnold, E.R. Melhem, C.H. Smith, M.D. Philips, M. Lowe, E. Fisher
American Journal of Neuroradiology Apr 2012, 33 (4) 695-700; DOI: 10.3174/ajnr.A2844
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