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Improved Turnaround Times | Median time to first decision: 12 days

Research ArticleBrain

Longitudinal Magnetization Transfer Imaging in Mild to Severe Alzheimer Disease

S. Ropele, R. Schmidt, C. Enzinger, M. Windisch, N.P. Martinez and F. Fazekas
American Journal of Neuroradiology March 2012, 33 (3) 570-575; DOI: https://doi.org/10.3174/ajnr.A2812
S. Ropele
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R. Schmidt
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C. Enzinger
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M. Windisch
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N.P. Martinez
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F. Fazekas
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    Fig 1.

    Averaged histograms from all AD patients for baseline and follow-up scans. Already at month 6, a reduction of both the peak position and the relative peak height are clearly visible.

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    Fig 2.

    Hemispheric difference of the association between MTR and MMSE in the hippocampus (HC) with a constantly stronger relationship on the left hemisphere.

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    Table 1:

    Baseline and follow-up MTR data, brain volume loss, and MMSE score

    ControlsAD BaselineAD Month 6AD Month 12
    n19282718
    Sex (M/F)8/1114/1414/138/10
    Age73.3 (3.2)76.5 (5.8)76.5 (5.9)76.1 (5.8)
    Global MTR
        Histogram peak position [%]67.21 (0.68)66.51 (1.0)a65.77 (0.90)b65.46 (1.20)b
        Histogram peak height [a.u.]0.591 (0.04)0.554 (0.04)a0.515 (0.07)b0.501 (0.06)b
        Mean histogram MTR [%]55.26 (1.30)53.55 (1.50)a51.63 (1.37)b50.89 (1.45)b
    Regional MTR
        Hippocampus MTR [%]63.68 (1.51)62.51 (1.21)a61.04 (1.42)b60.48 (1.15)b
        Caudate nucleus MTR [%]57.51 (1.01)57.15 (1.24)55.52 (2.23)b54.7 (2.06)b
        Thalamus MTR [%]62.51 (1.47)63.33 (1.52)61.78 (1.99)b61.35 (2.35)b
        Putamen MTR [%]57.74 (1.13)58.04 (1.49)58.12 (1.21)57.59 (1.47)b
    Brain volume loss [%]NANA1.04 (1.68)2.22 (1.87)
    Hippocampal volume loss [%]NANA1.77 (2.99)2.86 (3.62)
    MMSE27.6 (0.8)18.9 (2.8)18.8 (4.8)18.6 (4.3)
    • Note:—For the regional MTR analysis, values from both hemispheres were averaged; a.u. indicates arbitrary unit(s).

    • ↵a Significant difference between AD patients and controls.

    • ↵b Significant difference from baseline.

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    Table 2:

    Relation between deep gray matter MTR and cognition in AD patients at baseline

    MMSE
    rp
    Left hippocampus0.57<0.01
    Right hippocampus0.380.048
    Left putamen0.70<0.001
    Right putamen0.60<0.01
    Left thalamus0.52<0.01
    Right thalamus0.420.029
    Left caudate nucleus0.070.69
    Right caudate nucleus-0.060.72
    • Note:—Stronger correlations can be consistently observed in the left hemisphere.

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American Journal of Neuroradiology: 33 (3)
American Journal of Neuroradiology
Vol. 33, Issue 3
1 Mar 2012
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Cite this article
S. Ropele, R. Schmidt, C. Enzinger, M. Windisch, N.P. Martinez, F. Fazekas
Longitudinal Magnetization Transfer Imaging in Mild to Severe Alzheimer Disease
American Journal of Neuroradiology Mar 2012, 33 (3) 570-575; DOI: 10.3174/ajnr.A2812

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Longitudinal Magnetization Transfer Imaging in Mild to Severe Alzheimer Disease
S. Ropele, R. Schmidt, C. Enzinger, M. Windisch, N.P. Martinez, F. Fazekas
American Journal of Neuroradiology Mar 2012, 33 (3) 570-575; DOI: 10.3174/ajnr.A2812
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  • Microstructural Tissue Changes in Alzheimer Disease Brains: Insights from Magnetization Transfer Imaging
  • Regional Analysis of the Magnetization Transfer Ratio of the Brain in Mild Alzheimer Disease and Amnestic Mild Cognitive Impairment
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