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Improved Turnaround Times | Median time to first decision: 12 days

Research ArticleInterventional

Long-Term Follow-Up after Treatment of Intracranial Aneurysms with the Pipeline Embolization Device: Results from a Single Center

H.A. Deutschmann, M. Wehrschuetz, M. Augustin, K. Niederkorn and G.E. Klein
American Journal of Neuroradiology March 2012, 33 (3) 481-486; DOI: https://doi.org/10.3174/ajnr.A2790
H.A. Deutschmann
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M. Wehrschuetz
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M. Augustin
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K. Niederkorn
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G.E. Klein
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    Fig 1.

    A 76-year-old woman (patient 2) presents with a lobulated 4.1-mm recurrence of a previously coiled 8-mm ICA aneurysm (arrow, A). After placement of a single PED, the recurrence remains visible (arrow, B). At the 6-month angiographic follow-up, recurrence of the aneurysm neck is smaller, but still visible (arrow, C). MRA performed 13 months after PED placement demonstrates complete occlusion of the aneurysm (arrows, D–E) and patency of the parent artery (arrowhead, E). Angiography at 30 months confirms the results of the MR angiography, demonstrating complete occlusion of the aneurysm and excellent reconstruction of the parent artery (F).

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    Fig 2.

    A 61-year-old woman (patient 9) presents with a 16 × 13 mm recurrence of a previously ruptured and subsequently coiled 22-mm ICA aneurysm at the origin of the posterior communicating artery (arrow, A). After placement of a single PED, flow reduction in the superior compartment of the aneurysm recurrence is demonstrated (arrow, B). Due to the broad base of the recurrence, a second PED is placed in a telescopic fashion to sufficiently cover the aneurysm neck and the adjacent arterial segments. After placement of the second PED, significant flow reduction is demonstrated (arrow, C). At the 6-month angiographic follow-up, complete occlusion of the aneurysm recurrence is visible (arrow, D). At the 30-month angiographic follow-up, the aneurysm recurrence is still completely occluded, with excellent reconstruction of the parent artery (arrows E and F).

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    Fig 3.

    A 51-year-old woman (patient 11) harboring an incidental 10-mm paraophthalmic aneurysm (arrow, A). Immediately after treatment with a single PED, only minimal residual flow is visible on angiography (arrow, B). Angiography also depicts a minimal pre-existing lumen narrowing shortly before the funnel-shaped origin of the posterior communicating artery (arrowhead, A–B). At 6-month follow-up, angiography and 3D reconstruction of the rotational angiography show complete occlusion of the aneurysm and 75% stenosis at the distal end of the PED (arrows, C and D). At that time, the PED is fully deployed (E), but a small translucent rim along the inner surface of the PED is visible (arrows, F–G). Percutaneous balloon angioplasty is performed 7 months after PED placement. Control angiography after 13 months demonstrates only minimal residual stenosis (about 30% lumen narrowing; arrow, H) that is completely resolved, as demonstrated on the 31-month angiographic follow-up (arrows, I). However, a small translucent rim, possibly resembling a neointimal layer, is still visible on angiography (arrows, I). There are no signs of recurrence of the aneurysm, which remains completely occluded.

Tables

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  • Summary of patient characteristics and follow-up results

    PatientAge/SexPresentationLocationAneurysm Size (mm)Follow-Up (Angiographic; Mo)Follow-Up (CTA, MRA; Mo)Aneurysm Occlusiona (Mo)Clinical Outcome (GOS)
    155/FSAHCAV4.2314775
    276/FRecurrenceCAV4.13030135
    355/FIncidentalOPHT10292965
    464/MIncidentalCAV5.2272775
    568/Fst.p.stent/coil non poss.OPHT8293675
    657/Mst.p.stent/coil non poss.PcomA6.1303065
    755/MMass effectOPHT6.5313165
    848/FIncidentalPICA7303055
    961/FRecurrencePcomA16303055
    1049/FSAHOPHT772955
    1151/FIncidentalOPHT10314365
    1237/FSAHOPHT9282865
    • Note:—CAV indicates intracavernous segment of the internal carotid artery; mo = month; OPHT = paraophthalmic segment of the internal carotid artery.

    • ↵a The given numbers refer to the time the complete occlusion of the aneurysm is first detected either by angiography or by CTA/MRA.

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American Journal of Neuroradiology: 33 (3)
American Journal of Neuroradiology
Vol. 33, Issue 3
1 Mar 2012
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H.A. Deutschmann, M. Wehrschuetz, M. Augustin, K. Niederkorn, G.E. Klein
Long-Term Follow-Up after Treatment of Intracranial Aneurysms with the Pipeline Embolization Device: Results from a Single Center
American Journal of Neuroradiology Mar 2012, 33 (3) 481-486; DOI: 10.3174/ajnr.A2790

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Long-Term Follow-Up after Treatment of Intracranial Aneurysms with the Pipeline Embolization Device: Results from a Single Center
H.A. Deutschmann, M. Wehrschuetz, M. Augustin, K. Niederkorn, G.E. Klein
American Journal of Neuroradiology Mar 2012, 33 (3) 481-486; DOI: 10.3174/ajnr.A2790
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  • Follow-up of Intracranial Aneurysms Treated by Flow Diverters: Evaluation of Parent Artery Patency Using 3D-T1 Gradient Recalled-Echo Imaging with 2-Point Dixon in Combination with 3D-TOF-MRA with Compressed Sensing
  • Outcome of intracranial flow diversion according to the antiplatelet regimen used: a systematic review and meta-analysis
  • Prospective study on embolization of intracranial aneurysms with the pipeline device: the PREMIER study 1 year results
  • Antiplatelet therapy and the risk of ischemic and hemorrhagic complications associated with Pipeline embolization of cerebral aneurysms: a systematic review and pooled analysis
  • Transient in-stent stenosis at mid-term angiographic follow-up in patients treated with SILK flow diverter stents: incidence, clinical significance and long-term follow-up
  • Ultrasound for the evaluation of stenosis after flow diversion
  • Republished: Pipeline embolization device thrombosis induced peri-construct collateral channels
  • Current Trends and Results of Endovascular Treatment of Unruptured Intracranial Aneurysms at a Single Institution in the Flow-Diverter Era
  • Pipeline Embolization Device with or without Adjunctive Coil Embolization: Analysis of Complications from the IntrePED Registry
  • Effect of antiplatelet therapy and platelet function testing on hemorrhagic and thrombotic complications in patients with cerebral aneurysms treated with the pipeline embolization device: a review and meta-analysis
  • Pipeline embolization device thrombosis induced peri-construct collateral channels
  • Periprocedural and mid-term technical and clinical events after flow diversion for intracranial aneurysms
  • Long-Term Follow-Up Results following Elective Treatment of Unruptured Intracranial Aneurysms with the Pipeline Embolization Device
  • Primary endovascular treatment of post-irradiated carotid pseudoaneurysm at the skull base with the Pipeline embolization device
  • Extra-Aneurysmal Flow Modification Following Pipeline Embolization Device Implantation: Focus on Regional Branches, Perforators, and the Parent Vessel
  • Failure of aneurysm occlusion by flow diverter: a role for surgical bypass and parent artery occlusion
  • Small Pipes: Preliminary Experience with 3-mm or Smaller Pipeline Flow-Diverting Stents for Aneurysm Repair prior to Regulatory Approval
  • Patency of the Anterior Choroidal Artery after Flow-Diversion Treatment of Internal Carotid Artery Aneurysms
  • Treatment of 14 intracranial aneurysms with the FRED system
  • Platelet function inhibitors and platelet function testing in neurointerventional procedures
  • Last-Recorded P2Y12 Reaction Units Value Is Strongly Associated with Thromboembolic and Hemorrhagic Complications Occurring Up to 6 Months after Treatment in Patients with Cerebral Aneurysms Treated with the Pipeline Embolization Device
  • What's Coming Down the Pipe--And Should We Be Excited, Concerned, or Both?
  • Endovascular Treatment of Intracranial Aneurysms With Flow Diverters: A Meta-Analysis
  • Pre-procedure P2Y12 reaction units value predicts perioperative thromboembolic and hemorrhagic complications in patients with cerebral aneurysms treated with the Pipeline Embolization Device
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More in this TOC Section

  • Safety, Efficacy, and Durability of Stent-Assisted Coiling Treatment of M2 (Insular) Segment MCA Aneurysms
  • Endovascular Management of Intracranial Dural AVFs: Transvenous Approach
  • A Meta-analysis of Combined Aspiration Catheter and Stent Retriever versus Stent Retriever Alone for Large-Vessel Occlusion Ischemic Stroke
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