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Improved Turnaround Times | Median time to first decision: 12 days

Research ArticleHead and Neck Imaging

Diagnostic Accuracy of 4D-CT for Parathyroid Adenomas and Hyperplasia

J.L. Chazen, A. Gupta, A. Dunning and C.D. Phillips
American Journal of Neuroradiology March 2012, 33 (3) 429-433; DOI: https://doi.org/10.3174/ajnr.A2805
J.L. Chazen
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A. Gupta
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A. Dunning
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C.D. Phillips
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  • Fig 1.
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    Fig 1.

    Axial noncontrast (A), axial early phase postcontrast (B), and axial delayed phase postcontrast (C) images show a hypoattenuated hypodense nodule contiguous with the left posterior thyroid gland, which demonstrates avid early contrast enhancement and washout. Pathology revealed a 600-mg parathyroid adenoma.

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    Fig 2.

    Coronal early phase postcontrast (A), axial early phase postcontrast (B), and axial delayed phase postcontrast (C) images showing an early enhancing 1.3-cm nodule in the right tracheoesophageal groove, with modest contrast washout representing a right inferior parathyroid gland in an orthotopic location. Pathology demonstrated a 3-g parathyroid adenoma.

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    Fig 3.

    Axial (A) and coronal (B) postcontrast images showing an enhancing retrosternal ectopic parathyroid adenoma.

Tables

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    Table 1:

    Descriptives

    VariableMean/FreqSD/Percent
    Age (yr)59.39.9
    Female gender (n)2674%
    BMI (kg/m2)26.85.6
    Weight (kg)73.216.9
    Lesion weight (mg)566.7611.0
    Prior neck surgery (n)26%
    Single-gland disease (n)2880%
    Multigland disease (n)720%
    Peak preoperative parathyroid hormone (pg/mL)190.3288.6
    Postoperative parathyroid hormone (pg/mL)29.527.0
    • Note:—Freq indicates frequency.

    • View popup
    Table 2:

    Distribution of findings

    VariablePathology Findings4D-CT Findings
    Mean/FreqSD/PercentMean/FreqSD/Percent
    Lesion detection
        Positive27100.0%27100.0%
        Negative00.0%00.0%
    Lesion location
        Right superior622.2%414.8%
        Right inferior622.2%829.6%
        Left superior933.3%829.6%
        Left inferior622.2%725.9%
    Lesion side
        Right1244.4%1244.4%
        Left1555.6%1555.6%
    Lesion z-axis
        Superior1555.6%1244.4%
        Inferior1244.4%1555.6%
    • Note:—Freq indicates frequency.

    • View popup
    Table 3:

    Single-gland lateralization

    Measure%RateExact Binomial 95% CINumeratorDenominator
    LowerUpper
    Sensitivity91.761.599.81112
    Specificity93.368.199.81415
    PPV91.761.599.81112
    PNV93.368.199.81415
    Accuracy92.675.799.12527
    CT SidePathology Side
    LeftRightTotal
    Left14115
    Right11112
    Total151227
    • View popup
    Table 4:

    Single-gland quadrant localization

    Measure%RateExact Binomial 95% CINumeratorDenominator
    LowerUpper
    Sensitivity85.757.298.21214
    Specificity10071.51001111
    PPV10073.51001212
    PNV84.654.698.11113
    Accuracy92.074.099.02325
    CT QuadrantPathology Quadrant
    InferiorSuperiorTotal
    Inferior11213
    Superior01212
    Total111425
    • View popup
    Table 5:

    Multigland disease

    Measure%RateExact Binomial 95% CINumeratorDenominator
    LowerUpper
    Sensitivity42.99.981.637
    Specificity10087.71002828
    PPV10029.210033
    PNV87.571.096.52832
    Accuracy88.673.396.83135
    CT MultiglandPathology Multigland
    NoYesTotal
    No28432
    Yes033
    Total28735
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American Journal of Neuroradiology: 33 (3)
American Journal of Neuroradiology
Vol. 33, Issue 3
1 Mar 2012
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Cite this article
J.L. Chazen, A. Gupta, A. Dunning, C.D. Phillips
Diagnostic Accuracy of 4D-CT for Parathyroid Adenomas and Hyperplasia
American Journal of Neuroradiology Mar 2012, 33 (3) 429-433; DOI: 10.3174/ajnr.A2805

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Diagnostic Accuracy of 4D-CT for Parathyroid Adenomas and Hyperplasia
J.L. Chazen, A. Gupta, A. Dunning, C.D. Phillips
American Journal of Neuroradiology Mar 2012, 33 (3) 429-433; DOI: 10.3174/ajnr.A2805
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  • Clinical Images: Four-Dimensional Computed Tomography--Future of Preoperative Parathyroid Adenoma Imaging
  • Accuracy of 2-Phase Parathyroid CT for the Preoperative Localization of Parathyroid Adenomas in Primary Hyperparathyroidism
  • Dynamic 4D MRI for Characterization of Parathyroid Adenomas: Multiparametric Analysis
  • Dynamic CT for Parathyroid Disease: Are Multiple Phases Necessary?
  • 4D-CT for Preoperative Localization of Abnormal Parathyroid Glands in Patients with Hyperparathyroidism: Accuracy and Ability to Stratify Patients by Unilateral versus Bilateral Disease in Surgery-Naive and Re-Exploration Patients
  • Dual-Energy 4-Phase CT Scan in Primary Hyperparathyroidism
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