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Research ArticlePediatrics

Optic Nerve Sheath Diameter on MR Imaging: Establishment of Norms and Comparison of Pediatric Patients with Idiopathic Intracranial Hypertension with Healthy Controls

B. Shofty, L. Ben-Sira, S. Constantini, S. Freedman and A. Kesler
American Journal of Neuroradiology February 2012, 33 (2) 366-369; DOI: https://doi.org/10.3174/ajnr.A2779
B. Shofty
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L. Ben-Sira
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S. Constantini
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S. Freedman
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A. Kesler
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  • Fig 1.
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    Fig 1.

    Example of our measurement method. ONSD is measured 10 mm anterior to the optic foramen. In this example, a distended nerve is measured.

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    Fig 2.

    Mean ONSD of each age group in our control cohort, stratified by sex. Error bars at the top of each column represent the standard error for that column, ranging from 0.07 to 0.16 mm.

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    Fig 3.

    Mean ONSD width by age group in controls versus patients with IIH.

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    Fig 4.

    Scattergraph and trend lines of the mean ONSD of both controls and patients with IIH.

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    Table 1:

    Revised modified Dandy criteriaa

    Criteria
    1) If symptoms or signs are present, they may only reflect those of generalized intracranial hypertension or papilledema
    2) Documented elevated intracranial pressure measured in the lateral decubitus position
    3) Normal CSF composition
    4) No evidence of hydrocephalus, mass, structural, or vascular lesion on MRI or contrast-enhanced CT for typical patients, and MRI and MR venography for all others
    5) No other cause of intracranial hypertension identified
    • ↵a All of the above criteria should be met in order to make the diagnosis of IIH.

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    Table 2:

    Study participant data organized by age group

    ControlIIH
    Total No.8629
    SexM: 41; F: 45M: 11; F: 28
    Age range4 mo-16 yr24 mo-17 yr
    (mean, 8.1 yr; median, 7.7 yr)(mean, 10.1 yr; median, 11.5 yr)
    Group I: 0–3 yr
        No.154
        ONSD (avg)3.1 mm4.35 mm
        SD0.23 mm0.7 mm
        CI (95%)0.12 mm0.69 mm
    Group II: 3–6 yr
        No.206
        ONSD (avg)3.41 mm4.37 mm
        SD0.42 mm0.57 mm
        CI (95%)0.18 mm0.46 mm
    Group III: 6–12 yr
        No.325
        ONSD (avg)3.55 mm4.25 mm
        SD0.38 mm0.32 mm
        CI (95%)0.13 mm0.28 mm
    Group IV: 12–18 yr
        No.1914
        ONSD (avg)3.56 mm4.69 mm
        SD0.32 mm0.7 mm
        CI (95%)0.14 mm0.37 mm
    • Note:—avg indicates average; CI, confidence interval.

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American Journal of Neuroradiology: 33 (2)
American Journal of Neuroradiology
Vol. 33, Issue 2
1 Feb 2012
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Cite this article
B. Shofty, L. Ben-Sira, S. Constantini, S. Freedman, A. Kesler
Optic Nerve Sheath Diameter on MR Imaging: Establishment of Norms and Comparison of Pediatric Patients with Idiopathic Intracranial Hypertension with Healthy Controls
American Journal of Neuroradiology Feb 2012, 33 (2) 366-369; DOI: 10.3174/ajnr.A2779

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Optic Nerve Sheath Diameter on MR Imaging: Establishment of Norms and Comparison of Pediatric Patients with Idiopathic Intracranial Hypertension with Healthy Controls
B. Shofty, L. Ben-Sira, S. Constantini, S. Freedman, A. Kesler
American Journal of Neuroradiology Feb 2012, 33 (2) 366-369; DOI: 10.3174/ajnr.A2779
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