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Research ArticleSpine Imaging and Spine Image-Guided Interventions
Open Access

MR Imaging Assessment of Lumbar Intervertebral Disk Degeneration and Age-Related Changes: Apparent Diffusion Coefficient versus T2 Quantitation

G. Niu, J. Yang, R. Wang, S. Dang, E.X. Wu and Y. Guo
American Journal of Neuroradiology October 2011, 32 (9) 1617-1623; DOI: https://doi.org/10.3174/ajnr.A2556
G. Niu
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J. Yang
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R. Wang
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S. Dang
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E.X. Wu
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Y. Guo
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References

  1. 1.↵
    1. Luoma K,
    2. Riihimaki H,
    3. Luukkonen R,
    4. et al
    . Low back pain in relation to lumbar disc degeneration. Spine (Phila Pa 1976) 2000; 25: 487–92
    CrossRef
  2. 2.↵
    1. Zuo J,
    2. Saadat E,
    3. Romero A,
    4. et al
    . Assessment of intervertebral disc degeneration with magnetic resonance single-voxel spectroscopy. Magn Reson Med 2009; 62: 1140–46
    CrossRefPubMed
  3. 3.↵
    1. Modic MT,
    2. Ross JS
    . Lumbar degenerative disk disease. Radiology 2007; 245: 43–61
    CrossRefPubMedWeb of Science
  4. 4.↵
    1. Waris E,
    2. Eskelin M,
    3. Hermunen H,
    4. et al
    . Disc degeneration in low back pain: a 17-year follow-up study using magnetic resonance imaging. Spine (Phila Pa 1976) 2007; 32: 681–84
    CrossRef
  5. 5.↵
    1. Griffith JF,
    2. Wang YX,
    3. Antonio GE,
    4. et al
    . Modified Pfirrmann grading system for lumbar intervertebral disc degeneration. Spine (Phila Pa 1976) 2007; 32: E708–12
    CrossRef
  6. 6.↵
    1. Schneiderman G,
    2. Flannigan B,
    3. Kingston S,
    4. et al
    . Magnetic resonance imaging in the diagnosis of disc degeneration: correlation with discography. Spine (Phila Pa 1976) 1987; 12: 276–81
    CrossRef
  7. 7.↵
    1. Pfirrmann CW,
    2. Metzdorf A,
    3. Zanetti M,
    4. et al
    . Magnetic resonance classification of lumbar intervertebral disc degeneration. Spine (Phila Pa 1976) 2001; 26: 1873–78
    CrossRef
  8. 8.↵
    1. Niinimäki J,
    2. Korkiakoski A,
    3. Ojala O,
    4. et al
    . Association between visual degeneration of intervertebral discs and the apparent diffusion coefficient. Magn Reson Imaging 2009; 27: 641–47
    CrossRefPubMed
  9. 9.↵
    1. Rajasekaran S,
    2. Babu JN,
    3. Arun R,
    4. et al
    . ISSLS prize winner: a study of diffusion in human lumbar discs—a serial magnetic resonance imaging study documenting the influence of the endplate on diffusion in normal and degenerate discs. Spine (Phila Pa 1976) 2004; 29: 2654–67
    CrossRef
  10. 10.↵
    1. Watanabe A,
    2. Benneker LM,
    3. Boesch C,
    4. et al
    . Classification of intervertebral disk degeneration with axial T2 mapping. AJR Am J Roentgenol 2007; 189: 936–42
    CrossRefPubMed
  11. 11.↵
    1. Perry J,
    2. Haughton V,
    3. Anderson PA,
    4. et al
    . The value of T2 relaxation times to characterize lumbar intervertebral disks: preliminary results. AJNR Am J Neuroradiol 2006; 27: 337–42
    Abstract/FREE Full Text
  12. 12.↵
    1. Trattnig S,
    2. Stelzeneder D,
    3. Goed S,
    4. et al
    . Lumbar intervertebral disc abnormalities: comparison of quantitative T2 mapping with conventional MR at 3.0 T. Eur Radiol 2010; 20: 2715–22
    CrossRefPubMed
  13. 13.↵
    1. Blumenkrantz G,
    2. Zuo J,
    3. Li X,
    4. et al
    . In vivo 3.0-Tesla magnetic resonance T1rho and T2 relaxation mapping in subjects with intervertebral disc degeneration and clinical symptoms. Magn Reson Med 2010; 63: 1193–200
    CrossRefPubMed
  14. 14.↵
    1. Marinelli NL,
    2. Haughton VM,
    3. Anderson PA
    . T2 relaxation times correlated with stage of lumbar intervertebral disk degeneration and patient age. AJNR Am J Neuroradiol 2010; 31: 1278–82
    Abstract/FREE Full Text
  15. 15.↵
    1. Nguyen AM,
    2. Johannessen W,
    3. Yoder JH,
    4. et al
    . Noninvasive quantification of human nucleus pulposus pressure with use of T1rho-weighted magnetic resonance imaging. J Bone Joint Surg Am 2008; 90: 796–802
    CrossRefPubMed
  16. 16.↵
    1. Paajanen H,
    2. Komu M,
    3. Lehto I,
    4. et al
    . Magnetization transfer imaging of lumbar disc degeneration: correlation of relaxation parameters with biochemistry. Spine (Phila Pa 1976) 1994; 19: 2833–37
    CrossRef
  17. 17.↵
    1. Chatani K,
    2. Kusaka Y,
    3. Mifune T,
    4. et al
    . Topographic differences of 1H-NMR relaxation times (T1, T2) in the normal intervertebral disc and its relationship to water content. Spine (Phila Pa 1976) 1993; 18: 2271–75
    CrossRef
  18. 18.↵
    1. Krueger EC,
    2. Perry JO,
    3. Wu Y,
    4. et al
    . Changes in T2 relaxation times associated with maturation of the human intervertebral disk. AJNR Am J Neuroradiol 2007; 28: 1237–41
    Abstract/FREE Full Text
  19. 19.↵
    1. Ludescher B,
    2. Effelsberg J,
    3. Martirosian P,
    4. et al
    . T2- and diffusion-maps reveal diurnal changes of intervertebral disc composition: an in vivo MRI study at 1.5 Tesla. J Magn Reson Imaging 2008; 28: 252–57
    CrossRefPubMed
  20. 20.↵
    1. Marinelli NL,
    2. Haughton VM,
    3. Munoz A,
    4. et al
    . T2 relaxation times of intervertebral disc tissue correlated with water content and proteoglycan content. Spine (Phila Pa 1976) 2009; 34: 520–24
    CrossRef
  21. 21.↵
    1. Drew SC,
    2. Silva P,
    3. Crozier S,
    4. et al
    . A diffusion and T2 relaxation MRI study of the ovine lumbar intervertebral disc under compression in vitro. Phys Med Biol 2004; 49: 3585–92
    CrossRefPubMed
  22. 22.↵
    1. Johannessen W,
    2. Auerbach JD,
    3. Wheaton AJ,
    4. et al
    . Assessment of human disc degeneration and proteoglycan content using T1rho-weighted magnetic resonance imaging. Spine (Phila Pa 1976) 2006; 31: 1253–57
    CrossRef
  23. 23.↵
    1. Antoniou J,
    2. Demers CN,
    3. Beaudoin G,
    4. et al
    . Apparent diffusion coefficient of intervertebral discs related to matrix composition and integrity. Magn Reson Imaging 2004; 22: 963–72
    CrossRefPubMed
  24. 24.↵
    1. Kealey SM,
    2. Aho T,
    3. Delong D,
    4. et al
    . Assessment of apparent diffusion coefficient in normal and degenerated intervertebral lumbar disks: initial experience. Radiology 2005; 235: 569–74
    CrossRefPubMed
  25. 25.↵
    1. Antoniou J,
    2. Mwale F,
    3. Demers CN,
    4. et al
    . Quantitative magnetic resonance imaging of enzymatically induced degradation of the nucleus pulposus of intervertebral discs. Spine (Phila Pa 1976) 2006; 31: 1547–54
    CrossRef
  26. 26.↵
    1. Urban JP,
    2. Holm S,
    3. Maroudas A,
    4. et al
    . Nutrition of the intervertebral disc: effect of fluid flow on solute transport. Clin Orthop Relat Res 1982: 296–302
  27. 27.↵
    1. Nguyen-minh C,
    2. Riley L 3rd.,
    3. Ho KC,
    4. et al
    . Effect of degeneration of the intervertebral disk on the process of diffusion. AJNR Am J Neuroradiol 1997; 18: 435–42
    Abstract
  28. 28.↵
    1. Cheung KM,
    2. Karppinen J,
    3. Chan D,
    4. et al
    . Prevalence and pattern of lumbar magnetic resonance imaging changes in a population study of one thousand forty-three individuals. Spine (Phila Pa 1976) 2009; 34: 934–40
    CrossRef
  29. 29.↵
    1. Pfirrmann CW,
    2. Metzdorf A,
    3. Elfering A,
    4. et al
    . Effect of aging and degeneration on disc volume and shape: a quantitative study in asymptomatic volunteers. J Orthop Res 2006; 24: 1086–94
    CrossRefPubMedWeb of Science
  30. 30.↵
    1. Van Breuseghem I,
    2. Bosmans HT,
    3. Elst LV,
    4. et al
    . T2 mapping of human femorotibial cartilage with turbo mixed MR imaging at 1.5 T: feasibility. Radiology 2004; 233: 609–14
    PubMed
  31. 31.↵
    1. Takatalo J,
    2. Karppinen J,
    3. Niinimaki J,
    4. et al
    . Prevalence of degenerative imaging findings in lumbar magnetic resonance imaging among young adults. Spine (Phila Pa 1976) 2009; 34: 1716–21
    CrossRef
  32. 32.↵
    1. Landis JR,
    2. Koch GG
    . The measurement of observer agreement for categorical data. Biometrics 1977; 33: 159–74
    CrossRefPubMedWeb of Science
  33. 33.↵
    1. Kurunlahti M,
    2. Kerttula L,
    3. Jauhiainen J,
    4. et al
    . Correlation of diffusion in lumbar intervertebral disks with occlusion of lumbar arteries: a study in adult volunteers. Radiology 2001; 221: 779–86
    PubMed
  34. 34.↵
    1. Kerttula LI,
    2. Jauhiainen JP,
    3. Tervonen O,
    4. et al
    . Apparent diffusion coefficient in thoracolumbar intervertebral discs of healthy young volunteers. J Magn Reson Imaging 2000; 12: 255–60
    CrossRefPubMed
  35. 35.↵
    1. Kerttula L,
    2. Kurunlahti M,
    3. Jauhiainen J,
    4. et al
    . Apparent diffusion coefficients and T2 relaxation time measurements to evaluate disc degeneration: a quantitative MR study of young patients with previous vertebral fracture. Acta Radiol 2001; 42: 585–91
    FREE Full Text
  36. 36.↵
    1. Xia Y
    . Magic-angle effect in magnetic resonance imaging of articular cartilage: a review. Invest Radiol 2000; 35: 602–21
    CrossRefPubMed
  37. 37.↵
    1. Boos N,
    2. Weissbach S,
    3. Rohrbach H,
    4. et al
    . Classification of age-related changes in lumbar intervertebral discs: 2002 Volvo Award in basic science. Spine (Phila Pa 1976) 2002; 27: 2631–44
    CrossRef
  38. 38.↵
    1. Leung VY,
    2. Hung SC,
    3. Li LC,
    4. et al
    . Age-related degeneration of lumbar intervertebral discs in rabbits revealed by deuterium oxide-assisted MRI. Osteoarthritis Cartilage 2008; 16: 1312–18
    CrossRefPubMedWeb of Science
  39. 39.↵
    1. Robinson D,
    2. Mirovsky Y,
    3. Halperin N,
    4. et al
    . Changes in proteoglycans of intervertebral disc in diabetic patients: a possible cause of increased back pain. Spine (Phila Pa 1976) 1998; 23: 849–55, discussion 856
    CrossRef
  40. 40.↵
    1. Lotan R,
    2. Oron A,
    3. Anekstein Y,
    4. et al
    . Lumbar stenosis and systemic diseases: is there any relevance? J Spinal Disord Tech 2008; 21: 247–51
    CrossRefPubMed
  41. 41.↵
    1. Sierra-Jimenez G,
    2. Sanchez-Ortiz A,
    3. Aceves-Avila FJ,
    4. et al
    . Tendinous and ligamentous derangements in systemic lupus erythematosus. J Rheumatol 2008; 35: 2187–91
    Abstract/FREE Full Text
  42. 42.↵
    1. Bornehag CG,
    2. Sundell J,
    3. Sigsgaard T,
    4. et al
    . Potential self-selection bias in a nested case-control study on indoor environmental factors and their association with asthma and allergic symptoms among pre-school children. Scand J Public Health 2006; 34: 534–43
    Abstract/FREE Full Text
  43. 43.↵
    1. Thompson JP,
    2. Pearce RH,
    3. Schechter MT,
    4. et al
    . Preliminary evaluation of a scheme for grading the gross morphology of the human intervertebral disc. Spine (Phila Pa 1976) 1990; 15: 411–15
    CrossRef
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G. Niu, J. Yang, R. Wang, S. Dang, E.X. Wu, Y. Guo
MR Imaging Assessment of Lumbar Intervertebral Disk Degeneration and Age-Related Changes: Apparent Diffusion Coefficient versus T2 Quantitation
American Journal of Neuroradiology Oct 2011, 32 (9) 1617-1623; DOI: 10.3174/ajnr.A2556

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MR Imaging Assessment of Lumbar Intervertebral Disk Degeneration and Age-Related Changes: Apparent Diffusion Coefficient versus T2 Quantitation
G. Niu, J. Yang, R. Wang, S. Dang, E.X. Wu, Y. Guo
American Journal of Neuroradiology Oct 2011, 32 (9) 1617-1623; DOI: 10.3174/ajnr.A2556
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