Article Figures & Data
Tables
- Table 1:
Thalamic volumetry and DTI findings from the GM with and without the thalamus, at study entry and after 15 months in healthy controls and patients with PPMSa
Variables Healthy Controls Patients with PPMS P Value NTV Baseline 6.11 (0.48) 4.11 (0.95) <0.001 % Change −1.9 (3.1) −4.7 (6.2) 0.39 Pa n.s. <.0001 Thalamic MD Baseline 0.87 (0.04) 1.08 (0.16) .002 % Change +4.0 (8.7) +2.0 (10.2) .61 Pb n.s. <.0001 Thalamic FA Baseline 0.23 (0.01) 0.21 (0.02) .002 % Change −5.0 (7.1) −12.2 (7.1) .01 Pb n.s. <.0001 GM without thalami MD Baseline 1.02 (0.04) 1.08 (0.06) .005 % Change +1.0 (2.4) +2.0 (6.2) n.s Pb n.s. n.s. GM without thalami FA Baseline 0.15 (0.06) 0.14 (0.11) n.s. % Change −6.1 (12.0) −16.1 (16.1) .06 Pb n.s. .009 -
a Values are means ± SDs in parentheses.
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b Pair-wise comparisons versus baseline values (the text for statistical analysis).
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- Table 2:
Thalamic volumetry and DTI findings at study entry and after 15 months in patients with PPMS with and without thalamic T2-visible lesionsa
Variables PPMS without Lesions PPMS with Lesions P Value NTV Baseline 4.49 (0.88) 3.62 (0.74) .001 % Change −3.7 (5.5) −5.8 (6.5) .22 Thalamic MD Baseline 1.01 (0.13) 1.19 (0.19) .001 % Change +2.4 (10.8) +0.9 (9.1) .60 Thalamic FA Baseline 0.21 (0.02) 0.20 (0.02) .05 % Change −12.8 (7.1) −11.7 (7.2) .60 -
a Values are means ± SDs in parentheses. See the text for statistical analysis.
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- Table 3:
Univariate logistic regression analysis of the predictive value of thalamic volumetry and DTI findings from the GM with and without the thalamus for patients with EDSS scores worsening during 5 years (dependent variable)a
Independent Variables Units OR (95% CI) PValues Baseline NTV 1 mL 1.25 (0.63–2.45) .53 Baseline thalamic FA 0.01 0.99 (0.97–1.02) .57 Baseline thalamic MD 0.01 mm2/s × 10−3 1.02 (0.98–1.06) .40 Average NTV thalamic volume change 1% 1.00 (0.91–1.11) .94 Average thalamic FA change 1% 0.87 (0.77–0.97) .01 Average thalamic MD change 1% 1.04 (0.97–1.11) .27 Thalamic lesions n.a. 1.06 (0.66–1.68) .82 Change in thalamic lesions Yes vs no 2.23 (0.40–12.5) .36 Baseline GM without the thalami FA 0.01 1.02 (0.99–1.06) .22 Baseline GM without the thalami MD 0.01 mm2/s ×10−3 1.14 (1.02–1.27) .019 Average GM without the thalami FA change 1% 0.99 (0.93–1.05) .63 Average GM without the thalami MD change 1% 1.03 (0.92–1.15) .64 -
a See the text for statistical analysis.
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