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Improved Turnaround Times | Median time to first decision: 12 days

Research ArticleHead and Neck Imaging

Carotid Artery Wall Thickness and Leukoaraiosis: Preliminary Results Using Multidetector Row CT Angiography

L. Saba, L. Pascalis, R. Sanfilippo, M. Anzidei, R. Bura, R. Montisci and G. Mallarini
American Journal of Neuroradiology May 2011, 32 (5) 955-961; DOI: https://doi.org/10.3174/ajnr.A2396
L. Saba
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L. Pascalis
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R. Sanfilippo
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M. Anzidei
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R. Bura
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R. Montisci
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G. Mallarini
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Article Figures & Data

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  • Fig 1.
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    Fig 1.

    Examples of LA. A, Grade 0. B, Grade 1. C, Grade 2. D, Grade 4.

  • Fig 2.
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    Fig 2.

    MDCTA axial image of a 79-year-old man. A, The white arrow indicates the right common carotid artery. B, A 200% magnification is shown, and the 3 measurements at 6, 9, and 12 o‘ clock positions are visible.

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    Fig 3.

    A, Box-and-whisker plot representing CAWT values according LA severity. B, Box-and-whisker plot representing age value according to LA severity.

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    Fig 4.

    ROC curve analysis.

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    Fig 5.

    Bland-Altman plot analysis for the CAWT reproducibility between observers.

Tables

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    Table 1:

    Clinical characteristics of the study populationa

    CharacteristicPatientsPValue
    With LA (n = 76)Without LA (n= 22)
    Age (yr)75.5 ± 5.972.2 ± 6.4.0027b
    Symptoms45 (59)9 (41).1286
    Sex (male)53 (70)12 (55).1843
    Coronary artery disease40 (53)8 (36).1789
    Tobacco use36 (47)9 (41).5924
    Hypertension61 (80)15 (77).7592
    Diabetes27 (36)2 (9).0167b
    Dyslipidemia50 (65)10 (45).0847
    • a Values in parentheses are percentages.

    • b P < .05.

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    Table 2:

    Logistic regression analysis

    VariableCoefficientSEPValueOR95% CI
    Age0.08030.0313.0103a1.08361.0192–1.1521
    CAD−0.62270.4307.14820.53650.2307–1.2478
    CAWT0.08110.0309.0087a1.08451.0207–1.1523
    Carotid stenosis0.29140.2012.11750.74720.5038–1.1084
    Diabetes−0.49570.4635.28480.60910.2456–1.5108
    Dislipidemia0.39810.424.34781.48890.6486–3.4181
    Tobacco0.43540.423.30331.54560.6746–3.5411
    Hypertension0.57010.5076.26141.76840.6539–4.7824
    Sex (male)0.38450.4254.36611.46890.6381–3.3812
    Mixed plaque0.22730.4683.62741.25520.5013–3.1427
    Fatty plaque1.19970.5447.0276a3.31921.1411–9.6542
    Calcified plaque0.41860.4134.31131.51990.6759–3.4175
    Constant−8.1382
    • a P < .05.

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    Table 3:

    ROC curve analysis for specific measurements of CAWT versus LA

    CriterionSensitivity95% CISpecificity95% CI+LR−LR
    ≥0.5100.0097.6–100.00.000.0–8.31.00
    <0.598.0394.3–99.64.650.7–15.81.030.42
    <0.694.0889.1–97.320.9310.1–36.01.190.28
    <0.785.5378.9–90.746.5131.2–62.31.600.31
    <0.873.6865.9–80.558.1442.1–73.01.760.45
    <0.9a62.80a54.3–70.2a72.09a56.3–84.7a2.24a0.52a
    <1.049.3441.1–57.679.0764.0–89.92.360.64
    <1.135.5327.9–43.786.0572.1–94.72.550.75
    <1.222.3716.0–29.893.0280.9–98.53.210.83
    <1.37.243.7–12.697.6787.7–99.63.110.95
    <1.46.583.2–11.8100.0091.7–100.00.93
    <1.50.000.0–2.4100.0091.7–100.01.00
    • a selected threshold.

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American Journal of Neuroradiology: 32 (5)
American Journal of Neuroradiology
Vol. 32, Issue 5
1 May 2011
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L. Saba, L. Pascalis, R. Sanfilippo, M. Anzidei, R. Bura, R. Montisci, G. Mallarini
Carotid Artery Wall Thickness and Leukoaraiosis: Preliminary Results Using Multidetector Row CT Angiography
American Journal of Neuroradiology May 2011, 32 (5) 955-961; DOI: 10.3174/ajnr.A2396

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Carotid Artery Wall Thickness and Leukoaraiosis: Preliminary Results Using Multidetector Row CT Angiography
L. Saba, L. Pascalis, R. Sanfilippo, M. Anzidei, R. Bura, R. Montisci, G. Mallarini
American Journal of Neuroradiology May 2011, 32 (5) 955-961; DOI: 10.3174/ajnr.A2396
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