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Research ArticleHead and NeckE
Open Access

Value of MR Venography for Detection of Internal Jugular Vein Anomalies in Multiple Sclerosis: A Pilot Longitudinal Study

R. Zivadinov, R. Galeotti, D. Hojnacki, E. Menegatti, M.G. Dwyer, C. Schirda, A.M Malagoni, K. Marr, C. Kennedy, I. Bartolomei, C. Magnano, F. Salvi, B. Weinstock-Guttman and P. Zamboni
American Journal of Neuroradiology May 2011, 32 (5) 938-946; DOI: https://doi.org/10.3174/ajnr.A2386
R. Zivadinov
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R. Galeotti
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D. Hojnacki
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E. Menegatti
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M.G. Dwyer
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C. Schirda
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A.M Malagoni
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K. Marr
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C. Kennedy
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I. Bartolomei
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C. Magnano
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F. Salvi
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B. Weinstock-Guttman
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P. Zamboni
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    Fig 1.

    Patient with MS (a 43-year-old woman) shows normal examination findings on TOF (A) and TRICKS (B) of both IJVs pretreatment. C, Doppler sonography shows the presence of a septum (arrow) in the right IJV (upper image) and an annulus (arrow) in the left IJV (lower image). D−F, Catheter venography (D) confirms the presence of a septum (arrow) in the right IJV and an annulus (arrow) in the left IJV. The posttreatment 6-month follow-up shows normal examination findings on TOF (E), TRICKS (F), and Doppler sonography (G).

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    Fig 2.

    Patient with MS (a 44-year-old man) has normal examination findings on TOF (A) and TRICKS (B) of both IJVs pretreatment. C, Doppler sonography shows the presence of stenoses in the right IJV (arrow, upper image) and in the left IJV (arrow, lower image). D, Catheter venography confirms the presence of stenosis (arrows) in the right IJV and in the left IJV. E–G, The posttreatment 6-month follow-up shows normal examination findings on TOF (E) and TRICKS (F), but no change in the stenosis (arrows) on Doppler sonography (G) in the right IJV (upper image) and in the left IJV (lower image).

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    Fig 3.

    Variability between the baseline (A, C, and E, TOF, TRICKS, and Doppler sonography, respectively) and follow-up (B, D, and F, TOF, TRICKS, and Doppler sonography, respectively) examinations in a 42-year-old healthy female control. Flattening of the left IJV (arrows) at follow-up is noted on the TOF (B) and TRICKS (D), whereas Doppler sonography shows normal examination findings like those at baseline (F).

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    Fig 4.

    Variability between the baseline (A, C, and E, TOF, TRICKS, and Doppler sonography, respectively) and follow-up (B, D, and F, TOF, TRICKS and Doppler sonography, respectively) examinations in a 39-year-old healthy male control. Flattening of the right IJV (arrows) present at the baseline (A and C) examination is not present at follow-up (B and D). Doppler sonography examination shows normal findings at baseline (E) and follow-up (F).

Tables

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    Table 1:

    MRV, Doppler sonography, and selective venography findings in patients with MS at baseline and 6-month follow-upa

    Patients with MS2D-TOF3D-TRICKSDSCV
    RIJVLIJVRIJVLIJVRIJVLIJVRIJVLIJV
    1–baselineNormalNormalNormalAbnormalAbnormalAbnormalNormalAbnormal
    1–6 moNormalNormalNormalNormalNormalNormal––
    2–baselineNormalNormalAbnormalAbnormalAbnormalAbnormalAbnormalAbnormal
    2–6 moAbnormalAbnormalAbnormalAbnormalAbnormalAbnormal––
    3–baselineNormalNormalNormalNormalAbnormalAbnormalAbnormalAbnormal
    3- 6 moNormalNormalNormalNormalNormalAbnormal––
    4–baselineNormalNormalNormalNormalNormalAbnormalNormalAbnormal
    4–6 moNormalNormalAbnormalAbnormalAbnormalNormal––
    5–baselineNormalNormalNormalNormalAbnormalNormalAbnormalNormal
    5–6 moNormalNormalNormalNormalAbnormalNormal––
    6–baselineNormalNormalNormalNormalAbnormalAbnormalAbnormalAbnormal
    6–6 moNormalNormalNormalNormalAbnormalAbnormal––
    7–baselineNormalAbnormalNormalAbnormalNormalAbnormalNormalAbnormal
    7–6 moNormalAbnormalAbnormalAbnormalNormalNormal––
    8–baselineAbnormalAbnormalAbnormalNormalAbnormalAbnormalAbnormalAbnormal
    8–6 moAbnormalAbnormalAbnormalAbnormalAbnormalAbnormal––
    9–baselineNormalAbnormalNormalNormalAbnormalAbnormalAbnormalAbnormal
    9–6 moAbnormalAbnormalNormalAbnormalAbnormalAbnormal––
    10–baselineNormalNormalNormalNormalAbnormalAbnormalAbnormalAbnormal
    10- 6 moNormalNormalNormalNormalNormalNormal––
    • a Absent and pinpoint IJV flow was considered abnormal on TOF and TRICKS; the presence of at least 1 of the following IJV parameters was considered abnormal on a DS examination: B-mode abnormalities (flaps, septa, web), stenoses, absence of detectable flow, and presence of reflux in both sitting and supine positions. On CV, the presence of stenosis >50% of the IJV diameter or at least 1 of the following anomalies was considered abnormal: annulus, septum/valve malformation, hypoplasia, twisting, membrane, and agenesis.

    • View popup
    Table 2:

    MRV and Doppler sonography findings in healthy controls at baseline and 6-month follow-upa

    Healthy ControlsTOFTRICKSDS
    RIJVLIJVRIJVLIJVRIJVLIJV
    1–baselineNormalNormalNormalNormalNormalNormal
    1–6 moNormalNormalNormalNormalNormalNormal
    2–baselineNormalNormalNormalNormalNormalNormal
    2–6 moNormalAbnormalNormalAbnormalNormalNormal
    3–baselineNormalNormalNormalNormalNormalNormal
    3–6 moNormalNormalNormalNormalNormalNormal
    4–baselineNormalNormalNormalNormalNormalNormal
    4–6 moNormalNormalNormalNormalNormalNormal
    5–baselineAbnormalNormalAbnormalNormalNormalAbnormal
    5–6 moNormalNormalAbnormalNormalAbnormalNormal
    6–baselineNormalNormalNormalNormalNormalAbnormal
    6–6 moNormalNormalNormalNormalNormalAbnormal
    • a Absent and pinpoint IJV flow was considered abnormal on TOF and TRICKS; the presence of at least 1 of the following IJV parameters was considered abnormal on a DS examination: B-mode abnormalities (flaps, septa, and web), stenoses, absence of detectable flow, and presence of reflux in both sitting and supine positions.

    • View popup
    Table 3:

    Sensitivity, specificity, PPV, and NPV of MRV (TOF and TRICKS) and Doppler sonography relative to catheter venography (criterion standard) for detection of IJV anomaliesa

    Measure/SideSensitivity (%)Specificity (%)PPV (%)NPV (%)
    TOF
        Right99 (44–100)33 (3–51)45 (12–65)99 (21–100)
        Left99 (21–100)45 (12–065)33 (3–51)99 (44–100)
        Both99 (51–100)33 (10–49)33 (10–49)99 (51–100)
    TRICKS
        Right99 (44–100)44 (8–64)49 (14–69)99 (34–100)
        Left99 (21–100)45 (12–65)33 (3–51)99 (44–100)
        Both99 (51–100)39 (14–56)35 (11–52)99 (57–100)
    DS
        Right79 (21–94)100 (65–100)99 (34–100)90 (53–98)
        Left99 (21–100)100 (70–100)99 (21–100)100 (70–100)
        Both82 (30–95)100 (81–100)99 (44–100)95 (73–99)
    • a 95% confidence intervals are shown in parentheses for all values.

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American Journal of Neuroradiology: 32 (5)
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R. Zivadinov, R. Galeotti, D. Hojnacki, E. Menegatti, M.G. Dwyer, C. Schirda, A.M Malagoni, K. Marr, C. Kennedy, I. Bartolomei, C. Magnano, F. Salvi, B. Weinstock-Guttman, P. Zamboni
Value of MR Venography for Detection of Internal Jugular Vein Anomalies in Multiple Sclerosis: A Pilot Longitudinal Study
American Journal of Neuroradiology May 2011, 32 (5) 938-946; DOI: 10.3174/ajnr.A2386

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Value of MR Venography for Detection of Internal Jugular Vein Anomalies in Multiple Sclerosis: A Pilot Longitudinal Study
R. Zivadinov, R. Galeotti, D. Hojnacki, E. Menegatti, M.G. Dwyer, C. Schirda, A.M Malagoni, K. Marr, C. Kennedy, I. Bartolomei, C. Magnano, F. Salvi, B. Weinstock-Guttman, P. Zamboni
American Journal of Neuroradiology May 2011, 32 (5) 938-946; DOI: 10.3174/ajnr.A2386
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