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Research ArticleNeurointervention
Open Access

Association of Hemodynamic Characteristics and Cerebral Aneurysm Rupture

J.R. Cebral, F. Mut, J. Weir and C.M. Putman
American Journal of Neuroradiology February 2011, 32 (2) 264-270; DOI: https://doi.org/10.3174/ajnr.A2274
J.R. Cebral
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F. Mut
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J. Weir
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C.M. Putman
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  • Fig 1.
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    Fig 1.

    Examples of aneurysms with simple (A) and complex (B) flow patterns. From left to right, the visualizations show isovelocity surfaces, velocity magnitudes on a cut plane, streamlines, and WSS distribution, all at peak systole.

  • Fig 2.
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    Fig 2.

    Examples of aneurysms with stable (A) and unstable (B) flow patterns. Visualizations at peak systole (top row of each panel) and end diastole (bottom row of each panel) are shown by using (from left to right) isovelocity surfaces, velocity magnitudes on a cut plane, streamlines, and WSS distribution.

  • Fig 3.
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    Fig 3.

    Examples of aneurysms with large (A) and small (B) impingement regions. From left to right, the visualizations show isovelocity surfaces, velocity magnitudes on a cut plane, streamlines, and WSS distribution, all at peak systole.

  • Fig 4.
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    Fig 4.

    Examples of aneurysms with diffuse (A) and concentrated (B) inflows. From left to right, the visualizations show isovelocity surfaces, velocity magnitudes on a cut plane, streamlines, and WSS distribution, all at peak systole.

Tables

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    Table 1:

    Interobserver variability analysis of hemodynamic characterization

    O1-O2AgreementsRandomκ95% CI
    Flow complexityS-SC-S210 (100%)113 (54%)11.0–1.0
    760
    S-CC-C
    0134
    Flow stabilityS-SU-S206 (98%)110 (53%)0.960.921–0.999
    794
    S-UU-U
    0127
    Inflow concentrationD-DC-D206 (98%)105 (50%)0.9620.952–0.999
    1072
    D-CC-C
    299
    Impingement sizeL-LS-L202 (96%)109 (52%)0.920.866–0.974
    797
    L-SS-S
    1123
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    Table 2:

    Statistical analyses of the associations between hemodynamic categories and aneurysm rupture

    UnrupturedRupturedχ2POR
    Flow complexity
        Simple621422.190<.00014.701
        Complex6569
    Flow stability
        Stable592010.694.00182.733
        Unstable6863
    Inflow concentration
        Diffuse852822.252<.00013.975
        Concentrated4255
    Impingement size
        Large622012.890.00063.005
        Small6563
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American Journal of Neuroradiology: 32 (2)
American Journal of Neuroradiology
Vol. 32, Issue 2
1 Feb 2011
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J.R. Cebral, F. Mut, J. Weir, C.M. Putman
Association of Hemodynamic Characteristics and Cerebral Aneurysm Rupture
American Journal of Neuroradiology Feb 2011, 32 (2) 264-270; DOI: 10.3174/ajnr.A2274

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Association of Hemodynamic Characteristics and Cerebral Aneurysm Rupture
J.R. Cebral, F. Mut, J. Weir, C.M. Putman
American Journal of Neuroradiology Feb 2011, 32 (2) 264-270; DOI: 10.3174/ajnr.A2274
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