Article Figures & Data
Figures
- Fig 1.
Effects of age on global FA, AD, and RD. A, Scatterplot of skeleton average FA versus age; B, scatterplot of skeleton average AD versus age; C, scatterplot of skeleton average RD versus age. A significant negative correlation was seen between age and global FA. A significant positive correlation was seen between age and global AD and between age and global RD; however, the correlation between age and global AD was weak. Simple linear regression curves (solid lines) and quadratic regression curves (dotted lines) are shown. The quadratic term was significant in AD and RD but not in FA.
- Fig 2.
Effects of age on regional FA, AD, and RD. White matter tracts in red-yellow show a significant age-related increase in FA, AD, and RD. White matter tracts in blue-green show a significant age-related decrease in FA, AD, and RD.
- Fig 3.
Scatterplots of mean FA (A), AD (B), and RD (C) versus age for voxels that showed a positive correlation between age and FA.
- Fig 4.
Scatterplots of mean FA (A), AD (B), and RD (C) versus age for voxels that showed a negative correlation between FA and age.
- Fig 5.
Effects of sex on regional FA, AD, and RD. White matter tracts in red-yellow show a significantly higher FA, AD, and RD in men compared with women. White matter tracts in blue-green show a significantly higher FA, AD, and RD in women compared with men.
Tables
Summary of TBSS analysis of aging effects on white matter integrity
Region FA Age-related decrease Body of corpus callosum Fornix Anterior limb of internal capsule External capsule Anterior cingulum Inferior longitudinal fasciculus Cerebellum Age-related increase Splenium of corpus callosum Corona radiata Posterior limb of internal capsule Superior longitudinal fasciculus AD Age-related increase Body of corpus callosum Fornix Posterior limb of internal capsule Corona radiata Superior longitudinal fasciculus RD Age-related decrease Splenium of corpus callosum Age-related increase Body of corpus callosum Fornix Inferior longitudinal fasciculus Anterior limb of internal capsule External capsule Cerebellum
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