Article Figures & Data
Figures
- Fig 1.
Results are presented at P < .001 whole-brain uncorrected for GM images and P < .01 for midbrain images; significant effects are marked with arrows and labeled. A, The comparison of control subjects and patients shows reduced tissue integrity only on MTR images in the left olfactory cortex bordering the amygdala (A3). B and C, MTR images also show effects in bilateral SNc (C3), whereas midbrain volume images indicate atrophy only in the left SNc (C1), and density images show no effect (C2). All GM images reveal an effect in the left parahippocampal gyrus (B1–3).
- Fig 2.
Results are presented at P < .001 whole-brain uncorrected, for GM images, and P < .01, for midbrain images; significant effects are marked with arrows and labeled. A, The comparison of control subjects and patients in H&Y stage 2 indicates reduced tissue integrity only on MTR images in the left olfactory cortex bordering on the amygdala (A3). B, MTR images also show effects in the bilateral SNc (B3), whereas midbrain volume and density images indicate tissue damage only in the left SNc (B1–2). C−F, When control subjects are compared with patients in H&Y stages 3 and 4, only MTR images show effects in the left olfactory cortex (C3) and right STG (E3). All images reveal tissue damage in the left parahippocampal gyrus (D1–3) and left SNc (F1–3).
- Fig 3.
Results are presented at P < .001 whole-brain uncorrected; significant effects are marked with arrows and labeled. A, The comparison of patients in H&Y stages 1 and 2 shows a significant effect in the subcallosal area on MTR images (A3), but not on GM volume or density maps (A1, A2). B and C, When patients in H&Y 3 and 4 are compared with patients in H&Y stage 2, only MTR images (C3) indicate a reduction in tissue integrity in the right STG. Both MTR images (B3) and GM volume maps (B1) show a progression of pathology in the left olfactory cortex. There are no significant differences in GM density between patients in H&Y stages 3 and 4 and patients in H&Y stage 2 (B2 and C2).
- Fig 4.
Results are presented at P < .001 whole-brain uncorrected; significant effects are marked with arrows and labeled. A and B, Only MTR images show a correlation with the UPDRS in the right STG (A3) and adjacent left ILF (B3). Neither GM volume maps (A1 and B1) nor GM density maps (A2 and B2) based on T1-weighted MRI indicate correlations with UPDRS.
