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Research ArticleHead and Neck ImagingE

Carotid Plaque Enhancement and Symptom Correlations: An Evaluation by Using Multidetector Row CT Angiography

L. Saba and G. Mallarini
American Journal of Neuroradiology November 2011, 32 (10) 1919-1925; DOI: https://doi.org/10.3174/ajnr.A2605
L. Saba
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G. Mallarini
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    Fig 1.

    A 67-year-old asymptomatic male patient. MDCT axial images before (A) and after (B) administration of contrast material. White arrows indicate the region of interest in the plaque. The red rectangle incorporates the region-of-interest area values, including area; and mean HU values, minimum and maximum.

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    Fig 2.

    Box-and-whisker plot between the observers for the region-of-interest area quantification.

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    Fig 3.

    Interobserver variability in the HU plaque enhancement.

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    Fig 4.

    ROC curve analysis between HU plaque enhancement and cerebrovascular symptoms.

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    Table 1:

    ROC curve analysis

    Criterion (HU value)Sensitivity95% CISpecificity95% CI+LR−LR
    ≥0100.0089.6–100.00.000.0–14.41.00NC
    >088.2472.5–96.650.0029.1–70.91.760.24
    >988.2472.5–96.658.3336.7–77.92.120.20
    >1085.2968.9–95.062.5040.6–81.22.270.24
    >1282.3565.5–93.266.6744.7–84.32.470.26
    >1376.4758.8–89.275.0053.3–90.23.060.31
    >15a76.47a58.8–89.2a83.33a62.6–95.2a4.59a0.28a
    >1670.5952.5–84.987.5067.6–97.25.650.34
    >1767.6549.5–82.687.5067.6–97.25.410.37
    >1964.7146.5–80.291.6773.0–98.77.760.39
    >2420.598.7–37.991.6773.0–98.72.470.87
    >2720.598.7–37.995.8378.8–99.34.940.83
    >3014.715.0–31.195.8378.8–99.33.530.89
    >315.880.9–19.7100.0085.6–100.0NC0.94
    >430.000.0–10.4100.0085.6–100.0NC1.00
    • ↵a CPE threshold value.

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    Table 2:

    Multiple logistic regression analysis

    Independent VariableCoefficientStandard ErrortPR
    CPE0.011740.006131,914.0315a0.532
    Stenosisb0.27770.129162,15.0366a0.409
    Fatty plaque0.284710.149191,908.0423a0.449
    Age (yr)0.001150.004590.25.80330.036
    CAD0.104720.113980.919.36280.012
    Hypertension−0.249820.13419−1.862.06880.02
    Dyslipidemia0.104850.123310.85.39930.053
    Sex (male)0.125850.136050.925.35960.262
    Current smoker0.188220.120591.561.12510.208
    • ↵a Statistically significant value.

    • ↵b >70% NASCET stenosis.

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American Journal of Neuroradiology: 32 (10)
American Journal of Neuroradiology
Vol. 32, Issue 10
1 Nov 2011
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Cite this article
L. Saba, G. Mallarini
Carotid Plaque Enhancement and Symptom Correlations: An Evaluation by Using Multidetector Row CT Angiography
American Journal of Neuroradiology Nov 2011, 32 (10) 1919-1925; DOI: 10.3174/ajnr.A2605

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Carotid Plaque Enhancement and Symptom Correlations: An Evaluation by Using Multidetector Row CT Angiography
L. Saba, G. Mallarini
American Journal of Neuroradiology Nov 2011, 32 (10) 1919-1925; DOI: 10.3174/ajnr.A2605
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