Article Figures & Data
Figures
- Fig 1.
Thalamic subdivision small and large region-of-interest anatomic locations. A, The small circular regions of interest are fixed at a diameter of 4 mm. Region-of-interest placements in the anterior, lateral, medial, and posterior (pulvinar) nuclei of the thalamus are shown on the FA (1) and ADC (2) maps. B, Large region-of-interest subdivisions are shown on the same FA and ADC maps.
- Fig 2.
Range of severity of PVL and whole thalamic regions of interest. Rows: A, Severe PVL. B, Mild PVL. C, Healthy control. Columns: 1) T2-weighted. 2) FLAIR. 3) FA. 4) ADC. The T2 and FLAIR images for the patients with PVL show periventricular hyperintensity. The severity of PVL in each case is evident from the degree of periventricular white matter volume loss compared with the control. The contours for acquiring the DTI metrics are shown on the FA and ADC images for the whole thalamus.
Tables
Mean (SD) P Valueb PVLa (n = 16) Controla (n = 68) PCA (yr) 5.7 (4.1) 6.0 (3.4) .80 FA 0.24 (0.02) 0.26 (0.02) .003 RA 0.20 (0.02) 0.22 (0.02) .004 VR 0.07 (0.01) 0.08 (0.01) .008 λ‖ (×10−3 mm2/s) 1.04 (0.13) 1.01 (0.07) .215 λ⊥ (×10−3 mm2/s) 0.73 (0.10) 0.69 (0.05) .020 ADC (×10−3 mm2/s) 0.83 (0.11) 0.79 (0.06) .056 -
a DTI data excluded in certain children with artifactual movement during imaging.
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b ANOVA.
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Mean (±SD) P Valuea PVL (n = 16) Control (n = 68) Anterior thalamus FA 0.30 (0.04) 0.30 (0.04) .828 RA 0.25 (0.03) 0.25 (0.04) .802 λ‖ (×10−3 mm2/s) 1.00 (0.08) 1.02 (0.07) .335 λ⊥ (×10−3 mm2/s) 0.65 (0.06) 0.66 (0.05) .519 ADC (×10−3 mm2/s) 0.77 (0.06) 0.78 (0.05) .348 Medial thalamus FA 0.23 (0.03) 0.25 (0.04) .116 RA 0.20 (0.03) 0.21 (0.03) .113 λ‖ (×10−3 mm2/s) 0.95 (0.09) 0.96 (0.07) .430 λ⊥ (×10−3 mm2/s) 0.68 (0.07) 0.69 (0.05) .881 ADC (×10−3 mm2/s) 0.77 (0.08) 0.78 (0.05) .584 Lateral thalamus FA 0.29 (0.06) 0.28 (0.05) .650 RA 0.25 (0.05) 0.24 (0.05) .649 λ‖ (×10−3 mm2/s) 1.00 (0.11) 0.98 (0.09) .371 λ⊥ (×10−3 mm2/s) 0.64 (0.07) 0.64 (0.05) .834 ADC (×10−3 mm2/s) 0.76 (0.07) 0.75 (0.05) .734 Pulvinar thalamus FA 0.25 (0.03) 0.24 (0.03) .794 RA 0.21 (0.03) 0.20 (0.02) .882 λ‖ (×10−3 mm2/s) 1.04 (0.11) 0.98 (0.07) .007 λ(×10−3 mm2/s) 0.72 (0.08) 0.68 (0.05) .024 ADC (×10−3 mm2/s) 0.83 (0.09) 0.78 (0.06) .011 -
a ANOVA.
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Mean (±SD) P Value 1 2 3 4 1 vs 2 vs 3 vs 4 2 vs 3 vs 4 Control (n = 68) Mild (n = 4) Moderate (n = 8) Severe (n = 4) Entire thalamus FA 0.26 (0.02) 0.25 (0.030 0.23 (0.01) 0.26 (0.01) .003 .069 λ⊥ (×10−3 mm2/s) 0.69 (0.05) 0.63 (0.06) 0.79 (0.08) 0.71 (0.08) .000 .013 Pulvinar λ‖ (× 10−3 mm2/s) 0.98 (0.07) 0.91 (0.15) 1.08 (0.07) 1.08 (0.07) .000 .026 λ⊥ (×10−3 mm2/s) 0.68 (0.05) 0.63 (0.07) 0.76 (0.06) 0.71 (0.06) .000 .024
