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Research ArticleHead and Neck

Diffusion MR Imaging Features of Skull Base Osteomyelitis Compared with Skull Base Malignancy

B. Ozgen, K.K. Oguz and A. Cila
American Journal of Neuroradiology January 2011, 32 (1) 179-184; DOI: https://doi.org/10.3174/ajnr.A2237
B. Ozgen
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K.K. Oguz
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A. Cila
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    Fig 1.

    MR images in a case of SBO (patient 8). A, Axial T1-weighted image demonstrates infiltration with decreased T1 signal intensity of the left jugular foramen (black arrow) extending to the poststyloid parapharyngeal space with loss of the cortical margin of the clivus on the left (white arrow). B, Axial postcontrast and fat-suppressed T1-weighted image reveals extensive enhancement of the affected region (arrows). C, Diffusion TRACE image of the same region shows increased signal intensity (arrows). D, Corresponding ADC map with the regions of interest placed to measure the ADC values from the abnormal soft tissues (on the left) and normal-appearing soft tissues (on the right).

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    Fig 2.

    Box-and-whisker plot comparing the mean ADC values of the affected soft tissues in SBO, NPC, lymphoma, and metastatic lesions. The horizontal line is the median (50th percentile) of the measured values; the top and bottom of the box represent the 25th and 75th percentiles, respectively; and whiskers indicate the range from the largest to the smallest observed data points. The plus sign within the whiskers indicates the mean value for each group. Note that despite the overlap between the ADC values of different groups, the ADCs of SBO are significantly higher than those of lymphoma and NPC. The dotted line represents the cutoff value (1.08 × 10−3 mm2/s) distinguishing SBO from NPC and lymphoma.

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    Fig 3.

    MR images (anatomic images and ADC maps) of patients from each group. A, Axial T1-weighted image of a patient with SBO demonstrates infiltration of the soft tissues around the EAC, in the retrocondylar fat space (white arrow), extending to the poststyloid parapharyngeal space and jugular foramen (black arrow). B, Axial T1-weighted image of a patient with NPC reveals a large infiltrative mass in the nasopharynx (black arrow) with a small area of clival infiltration (white arrow). C, Axial T1-weighted image of a patient with lymphoma with a low T1-signal-intensity mass around the left pterygoid process (arrow), extending to the masticator space. D, Axial T1-weighted image of a patient with undifferentiated carcinoma metastatic to the skull base with the low T1-signal-intensity metastases on the left (arrow). E−H, Corresponding ADC maps of the patients with SBO, NPC, lymphoma, and metastases, respectively, with the regions of interest placed to measure the ADC values.

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    Table 1:

    Clinical characteristics and pathologic diagnosis of the patients

    Group/Patient No.Age (yr)SexHistopathologic diagnosis
    SBO
        166MChronic inflammation and fibrosis
        241FActive chronic inflammation and fibrosis
        373MActive chronic inflammation and fibrosis
        463MActive chronic inflammation and fibrosis
        556MChronic inflammation and fibrosis
        656MChronic inflammation and fibrosis
        781MChronic inflammation and fibrosis
        857FChronic inflammation and fibrosis
        961MChronic inflammation, giant cell reaction, fibrosis
    NPC
        147MSCC, undifferentiated type
        247FSCC, undifferentiated type
        344MSCC, undifferentiated type
        461MSCC, undifferentiated type
        560MSCC, undifferentiated type
        637MSCC, moderately differentiated type
        724FSCC, undifferentiated type
        862MSCC, undifferentiated type
        912MSCC, undifferentiated type
    Lymphoma
        114MB-cell lymphoma
        214MB-cell lymphoma
        314MT-cell lymphoblastic-type lymphoma
        443FDiffuse large B-cell, immunoblastic type lymphoma
        583FDiffuse B-cell lymphoma
        637FDiffuse B-cell lymphoma
        726MT-cell lymphoblastic-type lymphoma
        820MB-cell lymphoma
        949MDiffuse large B-cell lymphoma
    Metastasis
        160MUndifferentiated carcinoma
        253MUndifferentiated carcinoma
        358MProstate carcinoma
        457MUndifferentiated carcinoma
        550MModerately differentiated carcinoma
        654FMultiple myeloma
        746MMultiple myeloma
        848MMultiple myeloma
        971MProstate carcinoma
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    Table 2:

    ADC values and ratios for each group

    DxADCSTADCNSTADCST/ADCNSTADCPONS
    SBO1.26 ± 0.19 (0.91–1.45)1.47 ± 0.18 (1.23–1.80)0.86 ± 0.10 (0.70–1.02)0.77 ± 0.09 (0.64–0.89)
    NPC0.74 ± 0.18 (0.51–1.03)1.53 ± 0.28 (1.23–1.9)0.46 ± 0.09 (0.27–0.57)0.75 ± 0.13 (0.61–1.05)
    Lymphoma0.59 ± 0.11 (0.41–0.80)1.53 ± 0.23 (1.20–1.87)0.37 ± 0.06 (0.24–57)0.79 ± 0.21 (0.67–0.86)
    Metastasis0.99 ± 0.34 (0.5–1.39)1.53 ± 0.35 (1.01–2.12)0.64 ± 0.32 (0.41–1.38)0.79 ± 0.04 (0.71–0.85)
    • The ADC values are expressed as mean ± SD (minimum ADC value − maximum ADC value) × 10−3 mm2/s; the ADC ratios, as mean ± SD (minimum − maximum).

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American Journal of Neuroradiology: 32 (1)
American Journal of Neuroradiology
Vol. 32, Issue 1
1 Jan 2011
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Cite this article
B. Ozgen, K.K. Oguz, A. Cila
Diffusion MR Imaging Features of Skull Base Osteomyelitis Compared with Skull Base Malignancy
American Journal of Neuroradiology Jan 2011, 32 (1) 179-184; DOI: 10.3174/ajnr.A2237

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Diffusion MR Imaging Features of Skull Base Osteomyelitis Compared with Skull Base Malignancy
B. Ozgen, K.K. Oguz, A. Cila
American Journal of Neuroradiology Jan 2011, 32 (1) 179-184; DOI: 10.3174/ajnr.A2237
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