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AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticleNeurointervention
Open Access

Provocative Test with Propofol: Experience in Patients with Cerebral Arteriovenous Malformations Who Underwent Neuroendovascular Procedures

C.E. Feliciano, R. de León-Berra, M.S. Hernández-Gaitán, H.M. Torres, O. Creagh and R. Rodríguez-Mercado
American Journal of Neuroradiology March 2010, 31 (3) 470-475; DOI: https://doi.org/10.3174/ajnr.A1855
C.E. Feliciano
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R. de León-Berra
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M.S. Hernández-Gaitán
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H.M. Torres
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O. Creagh
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R. Rodríguez-Mercado
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    Fig 1.

    A 47-year-old man with a right parieto-occipital grade 2 AVM discovered incidentally during a work-up for head trauma after a fall. A and B, AP and lateral views of the first diagnostic angiogram. C, Note arterials feeders coming from the MCA, ACA, and PCA, as well as n-BCA from 2 prior embolizations. D, After superselective catheterization of the AVM through a PCA feeder, propofol was injected, causing proximal left-legged weakness. Further embolization was withheld, and the patient was referred for radiosurgery after refusing surgery.

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    Fig 2.

    A 54-year-old woman with a right medial parietal grade 2 AVM who presented with chronic headaches and dizziness. A and B, AP and lateral views of the first diagnostic angiogram. C, Note prior embolization, which required assistance of aneurysm coils due to the fistulous nature of the lesion. Also note the microcatheterization of the AVM nidus through the ACA feeder. After a superselective Wada test with propofol, the patient showed no neurologic changes, yet after embolization, she developed left-leg distal paresis. D, Postoperative diffusion-weighted MR image shows an ischemic insult close to the embolization area. The patient improved to baseline after physical therapy.

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    Fig 3.

    A 63-year-old woman with a grade 1 right parietal AVM who presented with left-handed numbness. After discussion of management alternatives, she decided on an endovascular intervention. A and B, AP and lateral views of the diagnostic angiogram. A superselective Wada test with propofol was performed with positive results (embolizable ACA feeder). C, Embolization with n-BCA after placement of the aneurysm coil to slow transit time. D, Note that the follow-up angiogram after 2 months shows no recanalization.

Tables

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    Table 1:

    Clinical and demographic characteristics of the patient population

    Demographic and Clinical ParametersValue
    Age
        Median (yrs)52
        Range (yrs)11–76
    Sex
        Male12
        Female8
    Associated conditions
        HBP7
        DM3
        Hypercholesterolemia4
        CAD1
        Hypothyroidism1
        BA1
        BPH1
    Medications
        Calcium channel blockers3
        ACE4
        β-blockers2
        α-Agonists1
        AEDs
            Dilantin (phenytoin)3
            Tegretol (carbamazepine)1
            Levetiracetam3
            Valproic acid1
            Lamotrigine1
        Synthroid (levothyroxine)1
        Statins4
        Other psychiatric/neurologic4
    Clinical presentation
        Headaches9
        Seizures4
        TIAs1
        Paresthesias2
        ICH, SAH, IVH4
        Dizziness4
        Hemianopsia1
        Incidental3
    Pre-embolization neurologic deficits
        Blindness1
        Dysarthria1
        Nystagmus1
        Paresis1
        Dysesthesias1
        Hemianopsia1
    • View popup
    Table 2:

    AVM angiographic characteristics of the population

    Angiographic ParameterValue
    AVM locations
        Frontal3
        Parietal6
        Parieto-occipital4
        Temporoparietal1
        Occipital3
        Temporal2
        Cerebellar1
    AVM S-M grades
        15
        29
        35
        41
    Size (cms)
        ≤11
        ≤2 and >110
        ≤3 and >213
        ≤4 and >311
        ≤5 and >41
        ≤6 and >50
        ≤7 and >62
    Transit times (secs)
        0.58
        0.7521
        0.831
        1.05
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    Table 3:

    AVM flow characteristics (in terms of transit times) and the concentration of n-BCAa used with or without aneurysm coils

    n-BCAa0.5 Secs0.75 Secs0.83 Secs1 Sec
    50/50 with coils0000
    50/500200
    60/40 with coils4601
    60/400401
    65/35 with coils1101
    65/351300
    70/30 with coils1100
    70/301112
    Coils only0100
    • a Percentage of iodized oil (Lipiodol) over the percentage of n-BCA with or without coils.

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American Journal of Neuroradiology: 31 (3)
American Journal of Neuroradiology
Vol. 31, Issue 3
1 Mar 2010
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Cite this article
C.E. Feliciano, R. de León-Berra, M.S. Hernández-Gaitán, H.M. Torres, O. Creagh, R. Rodríguez-Mercado
Provocative Test with Propofol: Experience in Patients with Cerebral Arteriovenous Malformations Who Underwent Neuroendovascular Procedures
American Journal of Neuroradiology Mar 2010, 31 (3) 470-475; DOI: 10.3174/ajnr.A1855

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Provocative Test with Propofol: Experience in Patients with Cerebral Arteriovenous Malformations Who Underwent Neuroendovascular Procedures
C.E. Feliciano, R. de León-Berra, M.S. Hernández-Gaitán, H.M. Torres, O. Creagh, R. Rodríguez-Mercado
American Journal of Neuroradiology Mar 2010, 31 (3) 470-475; DOI: 10.3174/ajnr.A1855
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    Journal of NeuroInterventional Surgery 2012 4 5
  • Superselective methohexital challenge prior to intracranial endovascular embolization
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  • An Endovascular Procedure–Specific Neurological Examination Scheme for Intraprocedural Monitoring in Awake Patients
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    Journal of Clinical Neuroscience 2015 22 11
  • Feasibility of the Superselective Test with Propofol for Determining Eloquent Brain Regions in the Endovascular Treatment of Arteriovenous Malformations
    José A Jordán González, Juan Carlos Llibre Guerra, José A. Prince López, Frank Vázquez Luna, Raúl Marino Rodríguez Ramos, José Carlos Ugarte Suárez
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