Skip to main content
Advertisement

Main menu

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home

User menu

  • Alerts
  • Log in

Search

  • Advanced search
American Journal of Neuroradiology
American Journal of Neuroradiology

American Journal of Neuroradiology

ASHNR American Society of Functional Neuroradiology ASHNR American Society of Pediatric Neuroradiology ASSR
  • Alerts
  • Log in

Advanced Search

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home
  • Follow AJNR on Twitter
  • Visit AJNR on Facebook
  • Follow AJNR on Instagram
  • Join AJNR on LinkedIn
  • RSS Feeds

AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticleFunctionalE

Functional MR Imaging in Patients with Carotid Artery Stenosis before and after Revascularization

M. Schaaf, G. Mommertz, A. Ludolph, S. Geibprasert, G. Mühlenbruch, M. Das and T. Krings
American Journal of Neuroradiology November 2010, 31 (10) 1791-1798; DOI: https://doi.org/10.3174/ajnr.A2219
M. Schaaf
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
G. Mommertz
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
A. Ludolph
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
S. Geibprasert
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
G. Mühlenbruch
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
M. Das
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
T. Krings
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • Responses
  • References
  • PDF
Loading

Abstract

BACKGROUND AND PURPOSE: Significant extracranial stenosis of the ICA is a known risk factor for future stroke and it has been shown that revascularization reduces the risk of future stroke. We applied BOLD fMRI in patients with carotid artery stenosis before and after CEA. Our purpose was to determine whether fMRI is able to demonstrate impaired CVR and to identify patient parameters that are associated with postoperative changes of cerebral hemodynamics.

MATERIALS AND METHODS: Nineteen consecutive patients with symptomatic (n = 13) and asymptomatic (n = 6) stenosis of the ICA were prospectively recruited (male/female ratio = 16:3; age, 69 ± 8,1 years). fMRI using a simple bilateral motor task was performed immediately before and after CEA.

RESULTS: Mean BOLD MSC was significantly increased postoperatively (MSC, 0.13 ± 0.66; P = 0.0002). Patients with a stenosis of <80% demonstrated an increase in MSC (MSC, 0.32 ± 0.59; P ≤ .0001). Patients with previous ischemic stroke showed a larger MSC than patients with TIAs (stroke: MSC, 0.55 ± 0.65; P ≤ .0001; TIA: MSC, 0.05 ± 0.26; P = 0.054). Patients older than 70 years had a significantly larger MSC following surgery (≤70 years: MSC, −0.01 ± 0.39; P = .429; >70 years: MSC, 0.29 ± 0.48; P ≤ .0001).

CONCLUSIONS: BOLD fMRI can demonstrate changes in cerebral hemodynamics before and after CEA, indicative of an ameliorated CVR. This response is dependent on the age of the patient, the degree of preoperative stenosis, and the patient's symptoms.

Abbreviations

AF
amaurosis fugax
asymp
asymptomatic
BOLD
blood oxygen level–dependent
CBF
cerebral blood flow
CBV
cerebral blood volume
CEA
carotid endarterectomy
CO2
carbon dioxide
CPP
cerebral perfusion pressure
CVR
cerebrovascular reactivity
DWI
diffusion-weighed imaging
FLAIR
fluid-attenuated inversion recovery
fMRI
functional MR imaging
ICA
internal carotid artery
MRI
MR imaging
MSC
mean SC
N/A
not applicable
Pre
before
Post
after
SC
signal-intensity change
symp
symptomatic
T2WI
T2-weighted imaging
TIA
transient ischemic attack
  • Copyright © American Society of Neuroradiology
View Full Text
PreviousNext
Back to top

In this issue

American Journal of Neuroradiology: 31 (10)
American Journal of Neuroradiology
Vol. 31, Issue 10
1 Nov 2010
  • Table of Contents
  • Index by author
Advertisement
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on American Journal of Neuroradiology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Functional MR Imaging in Patients with Carotid Artery Stenosis before and after Revascularization
(Your Name) has sent you a message from American Journal of Neuroradiology
(Your Name) thought you would like to see the American Journal of Neuroradiology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Cite this article
M. Schaaf, G. Mommertz, A. Ludolph, S. Geibprasert, G. Mühlenbruch, M. Das, T. Krings
Functional MR Imaging in Patients with Carotid Artery Stenosis before and after Revascularization
American Journal of Neuroradiology Nov 2010, 31 (10) 1791-1798; DOI: 10.3174/ajnr.A2219

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
0 Responses
Respond to this article
Share
Bookmark this article
Functional MR Imaging in Patients with Carotid Artery Stenosis before and after Revascularization
M. Schaaf, G. Mommertz, A. Ludolph, S. Geibprasert, G. Mühlenbruch, M. Das, T. Krings
American Journal of Neuroradiology Nov 2010, 31 (10) 1791-1798; DOI: 10.3174/ajnr.A2219
del.icio.us logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Purchase

Jump to section

  • Article
    • Abstract
    • Abbreviations
    • Materials and Methods
    • Results
    • Discussion
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • Responses
  • References
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • Intervention versus Aggressive Medical Therapy for Cognition in Severe Asymptomatic Carotid Stenosis
  • Impairments in Cognitive Function and Brain Connectivity in Severe Asymptomatic Carotid Stenosis
  • Crossref (17)
  • Google Scholar

This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.

  • Impairments in Cognitive Function and Brain Connectivity in Severe Asymptomatic Carotid Stenosis
    Hsien-Lin Cheng, Chun-Jen Lin, Bing-Wen Soong, Pei-Ning Wang, Feng-Chi Chang, Yu-Te Wu, Kun-Hsien Chou, Ching-Po Lin, Pei-Chi Tu, I-Hui Lee
    Stroke 2012 43 10
  • Impaired hemodynamic response in the ischemic brain assessed with BOLD fMRI
    Shiori Amemiya, Akira Kunimatsu, Nobuhito Saito, Kuni Ohtomo
    NeuroImage 2012 61 3
  • The correlation of asymmetrical functional connectivity with cognition and reperfusion in carotid stenosis patients
    Kuo-Lun Huang, Ting-Yu Chang, Meng-Yang Ho, Wei-Hao Chen, Mei-Yu Yeh, Yeu-Jhy Chang, Ho-Fai Wong, Chien-Hung Chang, Chi-Hung Liu, Tsong-Hai Lee, Changwei W. Wu
    NeuroImage: Clinical 2018 20
  • Intervention versus Aggressive Medical Therapy for Cognition in Severe Asymptomatic Carotid Stenosis
    C.-J. Lin, F.-C. Chang, K.-H. Chou, P.-C. Tu, Y.-H. Lee, C.-P. Lin, P.-N. Wang, I.-H. Lee
    American Journal of Neuroradiology 2016 37 10
  • Reorganization of brain networks following carotid endarterectomy: an exploratory study using resting state functional connectivity with a focus on the changes in Default Mode Network connectivity
    Michele Porcu, Davide Craboledda, Paolo Garofalo, Luigi Barberini, Roberto Sanfilippo, Fulvio Zaccagna, Max Wintermark, Roberto Montisci, Luca Saba
    European Journal of Radiology 2019 110
  • Functional MRI in Neuro-Oncology: State of the Art and Future Directions
    Luca Pasquini, Kyung K. Peck, Mehrnaz Jenabi, Andrei Holodny
    Radiology 2023 308 3
  • Connectometry evaluation in patients undergoing carotid endarterectomy: an exploratory study
    Michele Porcu, Davide Craboledda, Paolo Garofalo, Giulio Columbano, Luigi Barberini, Roberto Sanfilippo, Fulvio Zaccagna, Max Wintermark, Roberto Montisci, Luca Saba
    Brain Imaging and Behavior 2019 13 6
  • Investigation of the BOLD-Based MRI Signal Time Course During Short Breath-Hold Periods for Estimation of the Cerebrovascular Reactivity
    Leonie Zerweck, Till-Karsten Hauser, Constantin Roder, Uwe Klose
    SN Comprehensive Clinical Medicine 2020 2 9
  • Previous chronic cerebral infarction is predictive for new cerebral ischemia after carotid endarterectomy
    Mehmet Besir Akpinar, Veysel Sahin, Neslin Sahin, Ahmet Feyzi Abacilar, İlker Kiris, Ihsan Sami Uyar, Faik Fevzi Okur
    Journal of Cardiothoracic Surgery 2015 10 1
  • Changes in Hemodynamic Response Patterns in Motor Cortices Measured by Task-Based Functional Magnetic Resonance Imaging in Patients With Moyamoya Disease
    Peng-Gang Qiao, Zhi-Wei Zuo, Cong Han, Juan Zhou, Hong-Tao Zhang, Lian Duan, Tianyi Qian, Gong-Jie Li
    Journal of Computer Assisted Tomography 2017 41 3

More in this TOC Section

  • Kurtosis and Epileptogenic Tubers: A Pilot Study
  • Glutaric Aciduria Type 1: DK vs. Conventional MRI
  • Multiparametric MRI in PEDS Pontine Glioma
Show more FUNCTIONAL

Similar Articles

Advertisement

Indexed Content

  • Current Issue
  • Accepted Manuscripts
  • Article Preview
  • Past Issues
  • Editorials
  • Editor's Choice
  • Fellows' Journal Club
  • Letters to the Editor
  • Video Articles

Cases

  • Case Collection
  • Archive - Case of the Week
  • Archive - Case of the Month
  • Archive - Classic Case

More from AJNR

  • Trainee Corner
  • Imaging Protocols
  • MRI Safety Corner
  • Book Reviews

Multimedia

  • AJNR Podcasts
  • AJNR Scantastics

Resources

  • Turnaround Time
  • Submit a Manuscript
  • Submit a Video Article
  • Submit an eLetter to the Editor/Response
  • Manuscript Submission Guidelines
  • Statistical Tips
  • Fast Publishing of Accepted Manuscripts
  • Graphical Abstract Preparation
  • Imaging Protocol Submission
  • Evidence-Based Medicine Level Guide
  • Publishing Checklists
  • Author Policies
  • Become a Reviewer/Academy of Reviewers
  • News and Updates

About Us

  • About AJNR
  • Editorial Board
  • Editorial Board Alumni
  • Alerts
  • Permissions
  • Not an AJNR Subscriber? Join Now
  • Advertise with Us
  • Librarian Resources
  • Feedback
  • Terms and Conditions
  • AJNR Editorial Board Alumni

American Society of Neuroradiology

  • Not an ASNR Member? Join Now

© 2025 by the American Society of Neuroradiology All rights, including for text and data mining, AI training, and similar technologies, are reserved.
Print ISSN: 0195-6108 Online ISSN: 1936-959X

Powered by HighWire