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Research ArticleHead and Neck

Postsurgical Intracranial Hypotension: Diagnostic and Prognostic Imaging Findings

D.R. Hadizadeh, A. Kovács, H. Tschampa, R. Kristof, J. Schramm and H. Urbach
American Journal of Neuroradiology January 2010, 31 (1) 100-105; DOI: https://doi.org/10.3174/ajnr.A1749
D.R. Hadizadeh
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A. Kovács
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H. Tschampa
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R. Kristof
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J. Schramm
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H. Urbach
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    Fig 1.

    Sag ratios defined as maximal anteroposterior midbrain/maximal bipeduncular diameter3 preoperatively (n = 12), on the day after surgery (n = 16), in the first week after surgery (n = 13), and on long-term follow-up examinations (n = 7). Note the temporary significant increase of the sag ratio and complete resolution at long-term follow-up. Error marks indicate SDs of measurements (n = number of patients).

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    Fig 2.

    Sagittal T1-weighted spin-echo (A) and coronal T2-weighted FSE images (B,C) after depth electrode placement for presurgical work-up. Sagittal (D), axial (E), and coronal (F) T2-weighted FSE images 5 days after left-sided hippocampectomy. Vasogenic edema with increased signal intensity on T2-weighted images and elevated ADC values on diffusion-weighted MR imaging (not shown) is present in the basal ganglia (E; open arrows) and, to a lesser extent, in the brain stem (D; open arrow). CSF loss causes noisy T2-weighted images (D-F) and sagging of the brain stem and cerebellum (D,F). Normally, the iter in the aqueduct is within 2 mm below the incisural line connecting the tuberculum sellae and the entrance of the vein of Galen into the straight sinus (A). With severe CSF loss, the iter and the splenium corporis callosi are displaced downwards (D). Note tonsillar displacement into the foramen magnum (arrows in F compared with B and C).

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    Fig 3.

    Axial FLAIR before right-sided temporal lobe lesionectomy (A,B), 1 day after the lesionectomy (C,D), and 5 years later (E,F). Note that sections in A, B, E, F are angulated along the temporal lobe length axis, whereas sections in C and D are angulated along the c.a.-c.p.-line. However, apart from the resection defect (C; thick arrow), moderate thalamic and basal ganglia hyperintensities (D; open arrow) and compressed ambient cisterns (C; arrows) are clearly visible. From a clinical standpoint, this 36-year-old woman had a complete recovery with resolution of the imaging findings (E,F).

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    Fig 4.

    Intracranial hypotension after spinal fixation with dural opening. Axial CT images show compressed ambient cisterns (A; arrows) and basal ganglia hypoattenuation (B; open arrow). On midline sagittal reformatted CT angiogram (C), only sparse CSF space is visible in the posterior fossa. Axial ADC map (D) and coronal FLAIR images show mainly cytotoxic edema of the gray matter. Increased signal intensity is also visible in the cerebellum (E,F) and, to a lesser extent, in the pons (F). From a clinical standpoint, this 60-year-old woman who underwent spinal surgery for lumbar spondylodiskitis has recovered fully from symptoms of intracranial hypotension.

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    Table 1:

    Imaging modalities and clinical outcome in 16 patients with intracranial hypotension

    Pt No.SexAge (y)Type of SurgeryImaging ModalitiesClinical OutcomemRS
    1M51Optic gliomaCT, MRIFull recovery0/5
    2M59Oligoastrocytoma WHO grade IICT, MRIFull recovery0/5
    3F362/3 resection of temporal lobeCT, DSA, MRIModerate deficit3/3
    4F37Granulomatous inflammationCT, MRIFull recovery0/5
    5M44Incidental MCA aneurysmCT, DSAFatal6/1
    6M58CavernomaCTFull recovery0/5
    7M67Colloid cystCT, DSAVegetative state5/2
    8M60Recurrent metastasisCTMild deficit2/4
    9M42Hippocampal sclerosisCT, MRI, DSAModerate deficit3/3
    10M39Astrocytoma WHO grade IICT, MRIFatal6/1
    11F44Select amygdaloCT, MRIFatal6/1
    12M59AVM, Spetzler & Martin grade ICT, MRI, DSAMild deficit2/4
    13F34Oligodendroglioma WHO grade IIICT, MRIModerate deficit3/3
    14F70Spondylodiskitis T6/7CT, MRIFull recovery0/5
    15F71Spondylodiskitis L4/5, spinal fixationCT, MRIFatal6/1
    16M88Bilat. subdural hematomas: hollow screwsCT, MRIMild deficit2/4
    • Note:—mRS indicates modified Rankin scale/Glasgow outcome score; DSA, digital subtraction angiography; MCA, middle cerebral artery; select amygdalo, selective amygdalohippocampectomy; AVM, arteriovenous malformation; M, male; F, female; WHO, World Health Organization; bilat, bilateral; MRI, MR imaging.

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    Table 2:

    Imaging findings in 16 patients with intracranial hypotension

    Pt No.tcesdfbscerangsagSag Ratiodilbgenl
    1n.d.yn.d.n.d.n.d.n0.83n.d.+n.d.
    2n.d.yn.d.n.d.n.d.y0.90n+n.d.
    3n.d.yny88y0.92n++n.d.
    4n.d.ynnn.d.n1.00n.d.+y
    5n.d.nn.d.n.d.n.d.y1.15n.d.+n.d.
    6n.d.nn.d.n.d.n.d.y0.92n.d.+n.d.
    7n.d.nn.d.n.d.70n1.09n.d.++n.d.
    8n.d.yn.d.n.d.n.d.y1.00n.d.+n.d.
    9n.d.nn.d.n.d.58y0.83n.d.++n.d.
    10n.d.nnyn.d.n0.87n.d.++n.d.
    11n.d.nyy44y1.11n+++y
    12n.d.nyyn.d.y0.88n++n.d.
    13n.d.nn.d.n.d.n.d.y0.92n.d.+n.d.
    14nyyy102y1.00n+n
    15nyyy130n0.96n+++n
    16yyyy105y1.00y++n.d.
    • Note:—tce indicates dural thickening and enhancement; sdf, subdural fluid collections; bs, brain stem hyperintensity; cer, cerebellar hyperintensities; ang, angle of vein of Galen to straight sinus; sag, brain sagging; sag ratio, maximal anterior-posterior midbrain diameter divided by maximal bipeduncular diameter; dil, dilation of intracranial dural sinuses and/or spinal epidural plexuses; bg, hyperintense thalamic/basal ganglia signal; enl, enlargement of pituitary gland; y, yes; n, no; n.d., not determinable.

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    Table 3:

    Correlation of imaging findings with clinical outcome parameters in 16 patients with intracranial hypotension

    mRSP ValueGOSP Valuen
    sdf0.360.171−0.381.14616
    bs0.258.537−0.206.6248
    cer0.756.030b−0.637.089c8
    ang−0.049.9160.049.9167
    sag−0.026.9230.120.65916
    Sag ratio0.442.087c−0.478.061c16
    dil0.059.9000.043.9277
    bg0.632.009a−0.646.007a16
    enl−0.408.5920.302.6984
    • a Statistically highly significant (P < .01).

    • b Statistically significant (P < .05).

    • c Strong tendency but not statistically significant.

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American Journal of Neuroradiology: 31 (1)
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Cite this article
D.R. Hadizadeh, A. Kovács, H. Tschampa, R. Kristof, J. Schramm, H. Urbach
Postsurgical Intracranial Hypotension: Diagnostic and Prognostic Imaging Findings
American Journal of Neuroradiology Jan 2010, 31 (1) 100-105; DOI: 10.3174/ajnr.A1749

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Postsurgical Intracranial Hypotension: Diagnostic and Prognostic Imaging Findings
D.R. Hadizadeh, A. Kovács, H. Tschampa, R. Kristof, J. Schramm, H. Urbach
American Journal of Neuroradiology Jan 2010, 31 (1) 100-105; DOI: 10.3174/ajnr.A1749
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