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Improved Turnaround Times | Median time to first decision: 12 days

Case ReportHead and Neck Imaging

Anterior-Segment Retinoblastoma Mimicking Pseudoinflammatory Angle-Closure Glaucoma: Review of the Literature and the Important Role of Imaging

R.R. Saket and M.F. Mafee
American Journal of Neuroradiology September 2009, 30 (8) 1607-1609; DOI: https://doi.org/10.3174/ajnr.A1565
R.R. Saket
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M.F. Mafee
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    Fig 1.

    A, CT scan of the orbits. The left globe is asymmetrically enlarged and is hyperattenuating compared with the contralateral right globe, reflective of glaucoma and total retinal detachment, respectively. No calcifications are present. B, Axial T2-weighted MR image. There is total retinal detachment with a large fluid-fluid level. The detached retina is irregular and diffusely thickened (black arrows), and there is an irregular intermediate-signal-intensity mass involving the ciliary body and iris circumferentially (open white arrow). C, Axial T1-weighted postcontrast MR image. There is diffuse enhancement of the thickened detached retina and the anterior segment mass (white arrows). This constellation of findings is consistent with diffuse infiltrating retinal neoplasm extending into the anterior ocular segment. There is no evidence of optic nerve invasion or extrascleral extension.

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    Fig 2.

    Histologic section of the enucleated left globe. A, Photomicrograph (hematoxylin-eosin [HE] stain) of the whole-mount specimen at original magnification ×2. The ciliary body is diffusely infiltrated with neoplastic cells with round basophilic nuclei. The cells form rosettes around central lumens, known as Flexner-Wintersteiner rosettes, which are characteristic of retinoblastoma. B, Photomicrograph (HE stain) of the whole-mount specimen at original magnification ×40. The neoplastic cells have round basophilic nuclei with scant cytoplasm and are arranged in a rosette around a central lumen.

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    Fig 3.

    Teratoid medulloepithelioma. A, Noncontrast axial CT scan shows a densely calcified mass of the ciliary body in the anterior segment of the right globe. Teratoid medulloepitheliomas can contain dystrophic calcifications due to the presence of hyaline cartilage tissue elements. B, Axial T1-weighted fat-saturated postcontrast MR image shows an enhancing mass of the ciliary body corresponding to the area of calcification on the CT scan. The mass is confined to the ciliary body; therefore, medulloepithelioma is more likely than diffuse infiltrating retinoblastoma. Alternative diagnoses for a ciliary body mass in pediatric patients include pyogenic granuloma, juvenile xanthogranuloma, mesoectodermal leiomyoma, and ciliary body cyst.

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American Journal of Neuroradiology: 30 (8)
American Journal of Neuroradiology
Vol. 30, Issue 8
1 Sep 2009
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R.R. Saket, M.F. Mafee
Anterior-Segment Retinoblastoma Mimicking Pseudoinflammatory Angle-Closure Glaucoma: Review of the Literature and the Important Role of Imaging
American Journal of Neuroradiology Sep 2009, 30 (8) 1607-1609; DOI: 10.3174/ajnr.A1565

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Anterior-Segment Retinoblastoma Mimicking Pseudoinflammatory Angle-Closure Glaucoma: Review of the Literature and the Important Role of Imaging
R.R. Saket, M.F. Mafee
American Journal of Neuroradiology Sep 2009, 30 (8) 1607-1609; DOI: 10.3174/ajnr.A1565
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