Skip to main content
Advertisement
  • Main menu
  • User menu
  • Search
  • English ▼
    • English
    • Afrikaans
    • Albanian
    • Amharic
    • Arabic
    • Armenian
    • Azerbaijani
    • Basque
    • Belarusian
    • Bengali
    • Bosnian
    • Bulgarian
    • Catalan
    • Cebuano
    • Chichewa
    • Chinese (Simplified)
    • Chinese (Traditional)
    • Corsican
    • Croatian
    • Czech
    • Danish
    • Dutch
    • Esperanto
    • Estonian
    • Filipino
    • Finnish
    • French
    • Frisian
    • Galician
    • Georgian
    • German
    • Greek
    • Gujarati
    • Haitian Creole
    • Hausa
    • Hawaiian
    • Hebrew
    • Hindi
    • Hmong
    • Hungarian
    • Icelandic
    • Igbo
    • Indonesian
    • Irish
    • Italian
    • Japanese
    • Javanese
    • Kannada
    • Kazakh
    • Khmer
    • Korean
    • Kurdish (Kurmanji)
    • Kyrgyz
    • Lao
    • Latin
    • Latvian
    • Lithuanian
    • Luxembourgish
    • Macedonian
    • Malagasy
    • Malay
    • Malayalam
    • Maltese
    • Maori
    • Marathi
    • Mongolian
    • Myanmar (Burmese)
    • Nepali
    • Norwegian
    • Pashto
    • Persian
    • Polish
    • Portuguese
    • Punjabi
    • Romanian
    • Russian
    • Samoan
    • Scottish Gaelic
    • Serbian
    • Sesotho
    • Shona
    • Sindhi
    • Sinhala
    • Slovak
    • Slovenian
    • Somali
    • Spanish
    • Sudanese
    • Swahili
    • Swedish
    • Tajik
    • Tamil
    • Telugu
    • Thai
    • Turkish
    • Ukrainian
    • Urdu
    • Uzbek
    • Vietnamese
    • Welsh
    • Xhosa
    • Yiddish
    • Yoruba
    • Zulu

Main menu

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • Advancing NeuroMRI with High-Relaxivity Contrast Agents
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home

User menu

  • Alerts
  • Log in

Search

  • Advanced search
American Journal of Neuroradiology
American Journal of Neuroradiology

American Journal of Neuroradiology

ASHNR American Society of Functional Neuroradiology ASHNR American Society of Pediatric Neuroradiology ASSR
  • Alerts
  • Log in

Advanced Search

English ▼
  • English
  • Afrikaans
  • Albanian
  • Amharic
  • Arabic
  • Armenian
  • Azerbaijani
  • Basque
  • Belarusian
  • Bengali
  • Bosnian
  • Bulgarian
  • Catalan
  • Cebuano
  • Chichewa
  • Chinese (Simplified)
  • Chinese (Traditional)
  • Corsican
  • Croatian
  • Czech
  • Danish
  • Dutch
  • Esperanto
  • Estonian
  • Filipino
  • Finnish
  • French
  • Frisian
  • Galician
  • Georgian
  • German
  • Greek
  • Gujarati
  • Haitian Creole
  • Hausa
  • Hawaiian
  • Hebrew
  • Hindi
  • Hmong
  • Hungarian
  • Icelandic
  • Igbo
  • Indonesian
  • Irish
  • Italian
  • Japanese
  • Javanese
  • Kannada
  • Kazakh
  • Khmer
  • Korean
  • Kurdish (Kurmanji)
  • Kyrgyz
  • Lao
  • Latin
  • Latvian
  • Lithuanian
  • Luxembourgish
  • Macedonian
  • Malagasy
  • Malay
  • Malayalam
  • Maltese
  • Maori
  • Marathi
  • Mongolian
  • Myanmar (Burmese)
  • Nepali
  • Norwegian
  • Pashto
  • Persian
  • Polish
  • Portuguese
  • Punjabi
  • Romanian
  • Russian
  • Samoan
  • Scottish Gaelic
  • Serbian
  • Sesotho
  • Shona
  • Sindhi
  • Sinhala
  • Slovak
  • Slovenian
  • Somali
  • Spanish
  • Sudanese
  • Swahili
  • Swedish
  • Tajik
  • Tamil
  • Telugu
  • Thai
  • Turkish
  • Ukrainian
  • Urdu
  • Uzbek
  • Vietnamese
  • Welsh
  • Xhosa
  • Yiddish
  • Yoruba
  • Zulu
  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • Advancing NeuroMRI with High-Relaxivity Contrast Agents
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home
  • Follow AJNR on Twitter
  • Visit AJNR on Facebook
  • Follow AJNR on Instagram
  • Join AJNR on LinkedIn
  • RSS Feeds

AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates


Improved Turnaround Times | Median time to first decision: 12 days

OtherReview Articles
Open Access

Functional Imaging of Central Nervous System Involvement in Complex Regional Pain Syndrome

P. Schwenkreis, C. Maier and M. Tegenthoff
American Journal of Neuroradiology August 2009, 30 (7) 1279-1284; DOI: https://doi.org/10.3174/ajnr.A1630
P. Schwenkreis
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
C. Maier
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
M. Tegenthoff
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • Responses
  • References
  • PDF
Loading

Article Figures & Data

Figures

  • Fig 1.
    • Download figure
    • Open in new tab
    • Download powerpoint
    Fig 1.

    Correlation analysis. BOLD contrast negatively correlates to mean sustained pain levels (A) and 2-point-discrimination thresholds (B). Pain-related BOLD contrast is found in Brodmann area (BA) 1 of the S1 (A), whereas perception-related BOLD contrast is found in BA 2 of S1 (B). Both analyses reveal BOLD contrast localized in the same region of S2. NRS indicates numeric rating scale. Reprinted with permission of Elsevier from Pleger et al.32

  • Fig 2.
    • Download figure
    • Open in new tab
    • Download powerpoint
    Fig 2.

    Changes in S1 representation, pain intensity, and discrimination ability during the course of therapy in a single patient. BOLD contrast received from cortical maps on S1 contralateral to the healthy (left image) and to the CRPS-affected side (right, images of 3 consecutive measurements). Contrast maps are shown from above, projected on the individual rendered T1-weighted MR imaging dataset. The diagram below shows 2-point-discrimination thresholds of the healthy index finger (left column) and of the CRPS-affected index finger (right, columns indicate values of 3 consecutive measurements) as well as the intensity of CRPS pain (yellow rhombus, 3 consecutive evaluations). NRS indicates numeric rating scale. Reprinted with permission of Wiley-Liss from Pleger et al.34

  • Fig 3.
    • Download figure
    • Open in new tab
    • Download powerpoint
    Fig 3.

    A, Contrast map of the general linear model (GLM) calculated by subtracting the tapping condition of controls (right hand) from the tapping condition in patients (CRPS-affected side [ie, right hand]). Brain sections are referred to by the superior-inferior level in millimeters relative to a line through the anterior and posterior commissure. Z-score indicates level of significance. B, Contrast map of the GLM calculated by subtracting the tapping condition on the unaffected side (ie, left hand) from the affected side (ie, right hand) in patients with CRPS. Brain sections are referred to by the superior-inferior level in millimeters relative to a line through the anterior and posterior commissure. Z-score indicates level of significance. C, Implementation of the individual degrees of motor impairment (z-values of tapping frequencies [ie, values of the individual maximum tapping frequencies normalized to the mean maximum tapping frequencies of controls]) as regressors in the GLM model for the condition “tapping on the CRPS-affected side.” With this approach, brain areas correlating with the degree of motor impairment are isolated. Key areas of activations are indicated according to the following abbreviations: SFC indicates superior frontal cortex; MFC, middle frontal cortex; IFC, inferior frontal cortex; AIP, anterior intraparietal area, MIP, medial intraparietal area; mtc, middle temporal cortex; loc, lateral occipital complex. Reprinted with permission of Oxford University Press from Maihöfner et al.48

PreviousNext
Back to top

In this issue

American Journal of Neuroradiology: 30 (7)
American Journal of Neuroradiology
Vol. 30, Issue 7
August 2009
  • Table of Contents
  • Index by author
Advertisement
Print
Download PDF
Email Article
Cite this article
0 Responses
Respond to this article
Share
Bookmark this article
Functional Imaging of Central Nervous System Involvement in Complex Regional Pain Syndrome
P. Schwenkreis, C. Maier, M. Tegenthoff
American Journal of Neuroradiology Aug 2009, 30 (7) 1279-1284; DOI: 10.3174/ajnr.A1630
del.icio.us logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
Purchase

Jump to section

  • Article
    • Abstract
    • Somatosensory System
    • Motor System
    • Conclusions
    • References
  • Figures & Data
  • Info & Metrics
  • Responses
  • References
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • Comparison of subjective motor imagery abilities in CRPS compared to chronic limb pain and healthy controls: a cross sectional study
  • Comparison of subjective motor imagery abilities in CRPS compared to chronic limb pain and health controls: a cross sectional study
  • Comparison of subjective motor imagery abilities in CRPS compared to chronic limb pain and health controls: a cross sectional study
  • Atypical influence of biomechanical knowledge in Complex Regional Pain Syndrome-Towards a different perspective on body representation
  • CRPS: Central aspects related to locus of pain, pathophysiology, and mood
  • Crossref
  • Google Scholar

This article has not yet been cited by articles in journals that are participating in Crossref Cited-by Linking.

More in this TOC Section

  • An Atlas of Neonatal Neurovascular Imaging Anatomy as Depicted with Microvascular Imaging: The Intracranial Arteries
  • An Atlas of Neonatal Neurovascular Imaging Anatomy as Depicted with Microvascular Imaging: The Intracranial Veins
  • Clinical Translation of Hyperpolarized 13C Metabolic Probes for Glioma Imaging
Show more Review Articles

Similar Articles

Advertisement

Indexed Content

  • Current Issue
  • Accepted Manuscripts
  • Article Preview
  • Past Issues
  • Editorials
  • Editor's Choice
  • Fellows' Journal Club
  • Letters to the Editor
  • Video Articles

Cases

  • Case Collection
  • Archive - Case of the Week
  • Archive - Case of the Month
  • Archive - Classic Case

More from AJNR

  • Trainee Corner
  • Imaging Protocols
  • MRI Safety Corner
  • Book Reviews

Multimedia

  • AJNR Podcasts
  • AJNR Scantastics

Resources

  • Turnaround Time
  • Submit a Manuscript
  • Submit a Video Article
  • Submit an eLetter to the Editor/Response
  • Manuscript Submission Guidelines
  • Statistical Tips
  • Fast Publishing of Accepted Manuscripts
  • Graphical Abstract Preparation
  • Imaging Protocol Submission
  • Evidence-Based Medicine Level Guide
  • Publishing Checklists
  • Author Policies
  • Become a Reviewer/Academy of Reviewers
  • News and Updates

About Us

  • About AJNR
  • Editorial Board
  • Editorial Board Alumni
  • Alerts
  • Permissions
  • Not an AJNR Subscriber? Join Now
  • Advertise with Us
  • Librarian Resources
  • Feedback
  • Terms and Conditions
  • AJNR Editorial Board Alumni

American Society of Neuroradiology

  • Not an ASNR Member? Join Now

© 2025 by the American Society of Neuroradiology All rights, including for text and data mining, AI training, and similar technologies, are reserved.
Print ISSN: 0195-6108 Online ISSN: 1936-959X

Powered by HighWire
Email this Article

Thank you for your interest in spreading the word on American Journal of Neuroradiology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Functional Imaging of Central Nervous System Involvement in Complex Regional Pain Syndrome
(Your Name) has sent you a message from American Journal of Neuroradiology
(Your Name) thought you would like to see the American Journal of Neuroradiology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Cite this article
P. Schwenkreis, C. Maier, M. Tegenthoff
Functional Imaging of Central Nervous System Involvement in Complex Regional Pain Syndrome
American Journal of Neuroradiology Aug 2009, 30 (7) 1279-1284; DOI: 10.3174/ajnr.A1630

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

We use cookies on this site to enhance your user experience. By clicking any link on this page you are giving your consent for us to set cookies.