Skip to main content
Advertisement

Main menu

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • Advancing NeuroMRI with High-Relaxivity Contrast Agents
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home

User menu

  • Alerts
  • Log in

Search

  • Advanced search
American Journal of Neuroradiology
American Journal of Neuroradiology

American Journal of Neuroradiology

ASHNR American Society of Functional Neuroradiology ASHNR American Society of Pediatric Neuroradiology ASSR
  • Alerts
  • Log in

Advanced Search

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • Advancing NeuroMRI with High-Relaxivity Contrast Agents
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home
  • Follow AJNR on Twitter
  • Visit AJNR on Facebook
  • Follow AJNR on Instagram
  • Join AJNR on LinkedIn
  • RSS Feeds

AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates


Improved Turnaround Times | Median time to first decision: 12 days

Research ArticleBrain
Open Access

The Frequency and Extent of Mammillary Body Atrophy Associated with Surgical Removal of a Colloid Cyst

C.E. Denby, S.D. Vann, D. Tsivilis, J.P. Aggleton, D. Montaldi, N. Roberts and A.R. Mayes
American Journal of Neuroradiology April 2009, 30 (4) 736-743; DOI: https://doi.org/10.3174/ajnr.A1424
C.E. Denby
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
S.D. Vann
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
D. Tsivilis
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
J.P. Aggleton
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
D. Montaldi
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
N. Roberts
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
A.R. Mayes
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • Responses
  • References
  • PDF
Loading

References

  1. ↵
    Delay J, Brion S, Lemperiere T, et al. Postencephalitic Korsakoff's syndrome [in French]. Encephale 1968;57:475–94
    PubMed
  2. Gaffan D, Gaffan EA. Amnesia in man following transection of the fornix: a review. Brain 1991;114 (pt 6):2611–18
    Abstract/FREE Full Text
  3. ↵
    Aggleton JP, Brown MW. Episodic memory, amnesia and the hippocampal anterior thalamic axis. Behav Brain Sci 1999;22:425–66
    CrossRefPubMedWeb of Science
  4. ↵
    Mair WG, Warrington EL, Weiskrantz L. Memory disorder in Korsakoff's psychosis: a neuropathological and neuropsychological investigation of two cases. Brain 1979;102:749–83
    FREE Full Text
  5. Carmel PW. Surgical syndromes of the hypothalamus. Clin Neurosurg 1980;27:133–59
    PubMed
  6. Torvik A. Brain lesions in alcoholics: neuropathological observations. Acta Med Scand Suppl 1987;717:47–54
    PubMed
  7. Victor M. The irrelevance of mammillary body lesions in the causation of the Korsakoff amnestic state. Int J Neurol 1987 –1988; 21–22:51–57
  8. Mayes AR, Meudell PR, Pickering A, et al. Locations of lesions in Korsakoff's syndrome: neuropsychological and neuropathological data on two patients. Cortex 1988;24:1–22
  9. Loesch DV, Gilman S, Del Dotto J, et al. Cavernous malformation of the mammillary bodies: neuropsychological implications—case report. J Neurosurg 1995;83:354–58
    PubMed
  10. Harding A, Halliday G, Caine D, et al. Degeneration of anterior thalamic nuclei differentiates alcoholics with amnesia. Brain 2000;123 (pt 1):141–54
    Abstract/FREE Full Text
  11. Hildebrandt H, Müller S, Bussmann-Mork B, et al. Are some memory deficits unique to lesions of the mammillary bodies? J Clin Exp Neuropsychol 2001;l23:490–501
    PubMedWeb of Science
  12. ↵
    Freeman JL, Coleman LT, Wellard RM, et al. MR imaging and spectroscopic study of epileptogenic hypothalamic hamartomas: analysis of 72 cases. AJNR Am J Neuroradiol 2004;25:450–62
    Abstract/FREE Full Text
  13. ↵
    Vann SD, Aggleton JP. The mammillary bodies: two memory systems in one? Nat Rev Neurosci 2004;5:35–44
    CrossRefPubMedWeb of Science
  14. ↵
    Briess D, Cotter D, Doshi R, et al. Mamillary body abnormalities in schizophrenia. Lancet 1998;352:789–90
    PubMedWeb of Science
  15. ↵
    Bernstein H-G, Krause S, Krell D, et al. Strongly reduced number of parvalbumin-immunoreactive projection neurons in the mammillary bodies in schizophrenia: further evidence for limbic neuropathology. Ann N Y Acad Sci 2007;1096:120–27
    CrossRefPubMedWeb of Science
  16. ↵
    McMackin D, Cockburn J, Anslow P, et al. Correlation of fornix damage with memory impairment in six cases of colloid cyst removal. Acta Neurochir 1995;135:12–18
    CrossRefPubMed
  17. ↵
    Aggleton JP, McMackin D, Carpenter K, et al. Differential cognitive effects of colloid cysts in the third ventricle that spare or comprise the fornix. Brain 2000;123:800–15
    Abstract/FREE Full Text
  18. ↵
    Carmel PW. Vegetative dysfunctions of the hypothalamus. Acta Neurochir 1985;75:113–21
    CrossRefPubMed
  19. Cairns H, Mosberg WH Jr. Colloid cyst of the third ventricle. Surg Gyn Obst 1951;92:545–70
    PubMed
  20. ↵
    Aggleton JP, Mishkin M. Memory impairments following restricted medial thalamic lesions in monkeys. Exp Brain Res 1983;52:199–209
    PubMedWeb of Science
  21. ↵
    Loftus M, Knight RT, Amaral DG. An analysis of atrophy in the medial mammillary nucleus following hippocampal and fornix lesions in humans and nonhuman primates. Exp Neurol 2000;163:180–90
    CrossRefPubMed
  22. Poletti CE, Creswell G. Fornix system efferent projections in the squirrel monkey: an experimental degeneration study. J Comp Neurol 1977;175:101–28
    CrossRefPubMedWeb of Science
  23. ↵
    Aggleton JP, Vann SD, Saunders RC. Projections from the hippocampal region to the mammillary bodies in macaque monkeys. Eur J Neurosci 2005;22:2519–30
    CrossRefPubMedWeb of Science
  24. Rosene DL, Van Hoesen GW. Hippocampal efferents reach widespread areas of cerebral cortex and amygdala in the rhesus monkey. Science 1977;198:315–17
    Abstract/FREE Full Text
  25. ↵
    Saunders RC, Aggleton JP. Origin and topography of fibers contributing to the fornix in macaque monkeys. Hippocampus 2007;17:396–411
    CrossRefPubMedWeb of Science
  26. ↵
    Charness ME, DeLaPaz RL. Mammillary body atrophy in Wernicke's encephalopathy: antimortem identification using magnetic resonance imaging. Ann Neurol 1987;22:595–600
    CrossRefPubMedWeb of Science
  27. ↵
    Squire LR, Amaral DG, Press GA. The magnetic resonance imaging of the hippocampal formation and mammillary nuclei distinguish medial temporal lobe and diencephalic amnesia. J Neurosci 1990;10:3106–17
    Abstract
  28. ↵
    Urbach H, Siebenhaar G, Koenig R, et al. Limbic system abnormalities associated with Ammon's horn sclerosis do not alter seizure outcome after amygdalohippocampectomy. Epilepsia 2005;46:549–55
    CrossRefPubMed
  29. ↵
    Ozturk A, Yousem DM, Mahmood A, et al. Prevalence of asymmetry of mammillary body and fornix size on MR imaging. AJNR Am J Neuroradiol 2008;29:384–87
    Abstract/FREE Full Text
  30. ↵
    Copenhaver BR, Rabin LA, Saykin AJ, et al. The fornix and mammillary bodies in older adults with Alzheimer's disease, mild cognitive impairment, and cognitive complaints: a volumetric MRI study. Psychiat Res 2006;147:93–103. Epub 2006 Aug 22
    CrossRefPubMedWeb of Science
  31. ↵
    Martin RC, Hugg JW, Roth DL, et al. MRI extrahippocampal volumes and visual memory: correlations independent of MRI hippocampal volumes in temporal lobe epilepsy patients. J Int Neuropsychol Soc 1999;5:540–48
    CrossRefPubMedWeb of Science
  32. ↵
    Sullivan EV, Lane B, Deshmukh A, et al. In vivo mammillary body volume deficits in amnesic and non-amnesic alcoholics. Alcohol Clin Exp Res 1999;23:1629–36
    CrossRefPubMedWeb of Science
  33. ↵
    Tisserand DJ, Visser PJ, Van Boxtel MP, et al. The relation between global and limbic brain volumes on MRI and cognitive performance in healthy individuals across the age range. Neurobiol Aging 2000;21:569–76
    CrossRefPubMedWeb of Science
  34. ↵
    Rose J. The cell structure of the mammillary body in the mammals and in man. J Anat 1939;74 (pt 1):91–115
    PubMed
  35. ↵
    Bilir E, Craven W, Hugg J, et al. Volumetric MRI of the limbic system: anatomical determinants. Neuroradiology 1998;40:138–44
    CrossRefPubMedWeb of Science
  36. ↵
    Cruz-Orive LM. Precision of Cavalieri sections and slices with local errors. J Microsc 1999;193:182–98
    PubMedWeb of Science
  37. Cruz-Orive L. Systematic sampling in stereology. Bull Intern Stat Inst 1993;52:451–68
  38. ↵
    García-Fiñana M, Cruz-Orive LM, MacKay CE, et al. Comparison of MR imaging against physical sectioning to estimate the volume of human cerebral compartments. Neuroimage 2003;18:505–16
    CrossRefPubMedWeb of Science
  39. ↵
    Denby CE, Vann SD, Tsivilis D, et al. MRI measurement of fornix pathology: evidence of extensive fornix damage following surgical removal of colloid cysts in the third ventricle. Neurosci Img 2008;2:109–26
  40. Ashtari M, Barr WB, Schaul N, et al. Three-dimensional fast low-angle shot imaging and computerized volume measurement of the hippocampus in patients with chronic epilepsy of the temporal lobe. AJNR Am J Neuroradiol 1991;12:941–47
    Abstract/FREE Full Text
  41. Cook MJ, Fish DR, Shorvon SD, et al. Hippocampal volumetric and morphometric studies in frontal and temporal lobe epilepsy. Brain 1992;115:1001–15
    Abstract/FREE Full Text
  42. ↵
    Insausti R, Juotton K, Soininen H, et al. MR volumetric analysis of the human entorhinal, perirhinal, and temporopolar cortices. AJNR Am J Neuroradiol 1998;19:659–71
    Abstract
  43. Pruessner JC, Kohler S, Crane J, et al. Volumetry of temporopolar, perirhinal, entorhinal and parahippocampal cortex from high-resolution MR images: considering the variability of the collateral sulcus. Cereb Cortex 2002;12:1342–53
    Abstract/FREE Full Text
  44. ↵
    Howard MA, Roberts N, García-Finana M, et al. Volume estimation of prefrontal cortical subfields using MRI and stereology. Brain Res Brain Res Protoc 2003;10:125–38
    CrossRefPubMed
  45. ↵
    Widmalm SE, Brooks SL, Sano T, et al. Limitation of the diagnostic value of MR images for diagnosing temporomandibular joint disorders. Dentomaxillofac Radiol 2006;35:334–38
    Abstract/FREE Full Text
  46. ↵
    Sheedy D, Lara A, Garrick T, et al. Size of mamillary bodies in health and disease: useful measurements in neuroradiological diagnosis of Wernicke's encephalopathy. Alcohol Clin Exp Res 1999;23:1624–28
    PubMedWeb of Science
  47. ↵
    Vann SD, Saunders RC, Aggleton JP. Distinct, parallel pathways link the medial mammillary bodies to the anterior thalamus in macaque monkeys. Eur J Neurosci 2007;26:1575–86
    CrossRefPubMed
  48. ↵
    Tsivilis D, Vann SD, Denby CE, et al. A disproportionate role for the fornix and mammillary bodies in recall verses recognition memory. Nat Neurosci 2008;11:834–42
    CrossRefPubMedWeb of Science
PreviousNext
Back to top

In this issue

American Journal of Neuroradiology: 30 (4)
American Journal of Neuroradiology
Vol. 30, Issue 4
April 2009
  • Table of Contents
  • Index by author
Advertisement
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on American Journal of Neuroradiology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
The Frequency and Extent of Mammillary Body Atrophy Associated with Surgical Removal of a Colloid Cyst
(Your Name) has sent you a message from American Journal of Neuroradiology
(Your Name) thought you would like to see the American Journal of Neuroradiology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Cite this article
C.E. Denby, S.D. Vann, D. Tsivilis, J.P. Aggleton, D. Montaldi, N. Roberts, A.R. Mayes
The Frequency and Extent of Mammillary Body Atrophy Associated with Surgical Removal of a Colloid Cyst
American Journal of Neuroradiology Apr 2009, 30 (4) 736-743; DOI: 10.3174/ajnr.A1424

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
0 Responses
Respond to this article
Share
Bookmark this article
The Frequency and Extent of Mammillary Body Atrophy Associated with Surgical Removal of a Colloid Cyst
C.E. Denby, S.D. Vann, D. Tsivilis, J.P. Aggleton, D. Montaldi, N. Roberts, A.R. Mayes
American Journal of Neuroradiology Apr 2009, 30 (4) 736-743; DOI: 10.3174/ajnr.A1424
del.icio.us logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Purchase

Jump to section

  • Article
    • Abstract
    • Materials and Methods
    • Results
    • Discussion
    • Conclusions
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • Responses
  • References
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • Impairments in the early consolidation of spatial memories via group II mGluR agonism in the mammillary bodies
  • The Mammillary Bodies: A Review of Causes of Injury in Infants and Children
  • Signal Change in the Mammillary Bodies after Perinatal Asphyxia
  • Mammillothalamic Disconnection Alters Hippocampocortical Oscillatory Activity and Microstructure: Implications for Diencephalic Amnesia
  • Mammillothalamic disconnection alters hippocampo-cortical oscillatory activity and microstructure: Implications for diencephalic amnesia
  • Unraveling the contributions of the diencephalon to recognition memory: A review
  • Crossref
  • Google Scholar

This article has not yet been cited by articles in journals that are participating in Crossref Cited-by Linking.

More in this TOC Section

  • Predictors of Reperfusion in Patients with Acute Ischemic Stroke
  • Enhanced Axonal Metabolism during Early Natalizumab Treatment in Relapsing-Remitting Multiple Sclerosis
  • Progression of Microstructural Damage in Spinocerebellar Ataxia Type 2: A Longitudinal DTI Study
Show more Brain

Similar Articles

Advertisement

Indexed Content

  • Current Issue
  • Accepted Manuscripts
  • Article Preview
  • Past Issues
  • Editorials
  • Editor's Choice
  • Fellows' Journal Club
  • Letters to the Editor
  • Video Articles

Cases

  • Case Collection
  • Archive - Case of the Week
  • Archive - Case of the Month
  • Archive - Classic Case

More from AJNR

  • Trainee Corner
  • Imaging Protocols
  • MRI Safety Corner
  • Book Reviews

Multimedia

  • AJNR Podcasts
  • AJNR Scantastics

Resources

  • Turnaround Time
  • Submit a Manuscript
  • Submit a Video Article
  • Submit an eLetter to the Editor/Response
  • Manuscript Submission Guidelines
  • Statistical Tips
  • Fast Publishing of Accepted Manuscripts
  • Graphical Abstract Preparation
  • Imaging Protocol Submission
  • Evidence-Based Medicine Level Guide
  • Publishing Checklists
  • Author Policies
  • Become a Reviewer/Academy of Reviewers
  • News and Updates

About Us

  • About AJNR
  • Editorial Board
  • Editorial Board Alumni
  • Alerts
  • Permissions
  • Not an AJNR Subscriber? Join Now
  • Advertise with Us
  • Librarian Resources
  • Feedback
  • Terms and Conditions
  • AJNR Editorial Board Alumni

American Society of Neuroradiology

  • Not an ASNR Member? Join Now

© 2025 by the American Society of Neuroradiology All rights, including for text and data mining, AI training, and similar technologies, are reserved.
Print ISSN: 0195-6108 Online ISSN: 1936-959X

Powered by HighWire