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Improved Turnaround Times | Median time to first decision: 12 days

Research ArticleBrain

Assessment of Citrullinated Myelin by 1H-MR Spectroscopy in Early-Onset Multiple Sclerosis

K.K. Oguz, A. Kurne, A.O. Aksu, E. Karabulut, A. Serdaroglu, S. Teber, S. Haspolat, N. Senbil, S. Kurul and B. Anlar
American Journal of Neuroradiology April 2009, 30 (4) 716-721; DOI: https://doi.org/10.3174/ajnr.A1425
K.K. Oguz
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A. Kurne
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A.O. Aksu
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E. Karabulut
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A. Serdaroglu
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S. Teber
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S. Haspolat
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N. Senbil
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S. Kurul
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B. Anlar
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    Fig 1.

    Patient 12. A, Short-echo single-voxel 1H-MR spectroscopy (PRESS; TR, 1500 ms; TE, 30 ms; voxel size, 15 × 15 × 15 mm3) obtained from a right frontal CDL. B, Spectral narrowing with a resultant augmentation between 2.75 and 3.5 ppm shows the citrulline peak (arrow) between Cho and Cr peaks. C and D, No citrulline peak is present in the left frontal NAWM (C) and in the right temporal EDL (D).

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    Fig 2.

    A and B, Patient 4. A small citrulline peak (arrow) is shown between Cho and Cr peaks (A) in a voxel obtained from the left frontal NAWM, whereas it is absent in the voxel from the right frontal lesion (B) on short-echo 1H-MR spectroscopy. C, Patient 1. The voxel from the left NAWM again shows a citrulline peak (arrow).

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    Table 1:

    Presence and distribution of the citrulline peak in patients with MS according to the VOI site revealed by 1H-MR Spectroscopy

    Patient No.Citrulline Peak on 1H-MR Spectroscopy
    NAWMCDLEDL
    1+–na
    2na––
    3na–na
    4+––
    5–nana
    6++na
    7++na
    8––na
    9+–na
    10––+
    11––na
    12–+–
    13+–na
    14–––
    15–––
    16––na
    17–nana
    18++–
    19––na
    20––na
    21++–
    22–+na
    23––na
    24–+na
    25––na
    26––na
    27––na
    • Note:—na indicates that MR spectroscopy could not be performed due to absence of such a VOI site; +, present; –, absent; MS, multiple sclerosis; VOI, voxel of interest; NAWM, normal-appearing white matter; CDL, chronic demyelinating lesions; EDL, enhanced demyelinating lesions.

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    Table 2:

    Mean NAA/Cr, Cho/Cr, and mIns/Cr ratios obtained from the WM of healthy subjects, NAWM in MS, CDL, and EDL

    VOI SiteNAA/Cr (P* Value)Cho/Cr (P* Value)mIns/Cr (P* Value)
    WM of healthy subjects1.6101.0160.414
    (.704)†(.810)†(.907)†
    (.175)‡(.211)‡(.003)‡
    (.279)§(.326)§(.849)§
    NAWM in MS1.5601.0330.411
    (.704)*(.810)*(.907)*
    (.647)‡(.111)‡(.000)‡
    (.845)§(.939)§(.423)§
    CDL1.4521.1100.557
    (.175)*(.211)*(.003)*
    (.647)†(.111)†(.000)†
    (.917)§(.928)§(.097)§
    EDL1.4551.1200.404
    (.279)*(.326)*(.848)*
    (.845)†(.940)†(.423)†
    (.917)‡(.928)‡(.097)‡
    • Note:—NAA indicates N-acetylaspartate; Cr, creatine; Cho, choline; mIns, myo-inositol; WM, white matter.

    • * Value in comparison with the WM of healthy subjects.

    • † P value in comparison with the NAWM of MS.

    • ‡ P value in comparison with CDL.

    • § P value in comparison with EDL.

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American Journal of Neuroradiology: 30 (4)
American Journal of Neuroradiology
Vol. 30, Issue 4
April 2009
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Assessment of Citrullinated Myelin by 1H-MR Spectroscopy in Early-Onset Multiple Sclerosis
K.K. Oguz, A. Kurne, A.O. Aksu, E. Karabulut, A. Serdaroglu, S. Teber, S. Haspolat, N. Senbil, S. Kurul, B. Anlar
American Journal of Neuroradiology Apr 2009, 30 (4) 716-721; DOI: 10.3174/ajnr.A1425
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K.K. Oguz, A. Kurne, A.O. Aksu, E. Karabulut, A. Serdaroglu, S. Teber, S. Haspolat, N. Senbil, S. Kurul, B. Anlar
Assessment of Citrullinated Myelin by 1H-MR Spectroscopy in Early-Onset Multiple Sclerosis
American Journal of Neuroradiology Apr 2009, 30 (4) 716-721; DOI: 10.3174/ajnr.A1425

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