Article Figures & Data
Figures
- Fig 1.
Three cases (A, B, and C) of infarct affecting the dominant cerebral hemisphere associated with contralateral cerebellar hypoperfusion. PWI maps according to TTP show supratentorial and contralateral cerebellar hypoperfusion relative to the opposite hemisphere (first and third rows). DWI (second and fourth rows) shows acute infarct co-localized with supratentorial perfusion abnormality. The co-localized cerebellum (fourth row) shows no evidence of infarct in the region of the hypoperfusion.
- Fig 2.
ΔR2* (= −ln(S/S0)/TE) versus time curves of case C from Fig 1 in the cerebrum and cerebellum show a shift of bolus arrival time to the right side (ie, prolonged TTP) in the hypoperfused brain with acute infarct, and in the contralateral cerebellum without evidence of ischemia.
Tables
- Table 1:
Comparison between CCD− and CCD+ cases in patient age, DWI volume, and volume of abnormal TTP in the supratentorial ischemic lesion*
Age (y) DWI (cm3) TTP (cm3) CCD− CCD+ CCD− CCD+ CCD− CCD+ Mean 61.2 60.2 19.8 55.6 29.4 58.8 Median 62.0 58.5 5.2 32.3 2.4 40.8 SD 15.3 14.7 34.5 58.2 60.0 63.2 Minimum 15.0 30.0 0 1.8 0 0 Maximum 89.0 88.0 253.5 258.4 327.3 307.5 P value* .67 .0001 .004 Note:—CCD indicates crossed cerebellar diaschisis; DWI, diffusion-weighted imaging; TTP, time-to-peak.
* t test: 2-tail, 2-sample assuming unequal variances.
- Table 2:
Summary of differences in TTP and degree of CBF and CBV reduction of the affected hemisphere relative to the unaffected hemisphere in the cerebellum and cerebrum in CCD+ cases (n = 20)*†
ΔTTP Cerebellum (sec) ΔTTP Cerebrum (sec) % CBF Reduction Cerebellum % CBF Reduction Cerebrum % CBV Reduction Cerebellum %CBV Reduction Cerebrum Mean 2.02 4.98 22.75 31.33 6.39 −7.69 Median 1.60 4.48 19.27 28.65 8.75 −1.78 SD 1.29 3.10 10.94 17.71 17.56 18.81 Minimum 0.38 0.82 7.45 4.76 −39.33 −60.06 Maximum 4.53 12.39 52.13 76.35 37.92 18.63 P .001 .07 Note:—sec indicates second; CBF, cerebral blood flow; CBV, cerebral blood volume.
* t test: 2-tail, 2-sample assuming unequal variances.
† Note that calculation of CBF and CBV reduction assumes that these values are reduced in the affected hemisphere (ie, the cerebral hemisphere of acute infarction, or cerebellar hemisphere contralateral to the supratentorial infarction). ΔTTP therefore shows increase, and CBF shows reduction in the affected cerebrum and contralateral cerebellum. CBV, however, shows a wide range of values that are increased, unchanged, or decreased, but with a mean of modest reduction in the contralateral cerebellum (6.39 ± 17.56%) and modest net increase in the cerebrum (−7.69 ± 18.81%).
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