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Research ArticleHead and Neck Imaging

The Role of MR Imaging in Detecting Nodal Disease in Thyroidectomy Patients with Rising Thyroglobulin Levels

S.L. Kaplan, S.J. Mandel, R. Muller, Z.W. Baloch, E.R. Thaler and L.A. Loevner
American Journal of Neuroradiology March 2009, 30 (3) 608-612; DOI: https://doi.org/10.3174/ajnr.A1405
S.L. Kaplan
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S.J. Mandel
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R. Muller
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Z.W. Baloch
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E.R. Thaler
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L.A. Loevner
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    Fig 1.

    A 51-year-old woman with a history of thyroidectomy, left neck dissection, and rising thyroglobulin levels. A, Axial T1-weighted MR image shows a 12-mm solid left retropharyngeal node (asterisk) that is hyperintense relative to muscle. B, Axial T2-weighted MR image shows the left retropharyngeal lymph node. C, FDG-PET shows avid uptake in the left retropharyngeal node at the skull base, which did not concentrate radioiodine (not shown). Surgical resection confirmed metastatic papillary carcinoma. T indicates physiologic uptake in the palatine tonsils.

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    Fig 2.

    A 52-year-old woman being evaluated with MR imaging for an unrelated indication. An incidental right parapharyngeal space mass was identified. A, Gadolinium-enhanced axial T1-weighted MR image shows a multiseptate cystic rim-enhancing mass in the right parapharyngeal space. B, Axial T2-weighted MR image shows the multiseptate parapharyngeal mass. The patient went directly to surgical resection, which identified metastatic papillary cancer in a high level II lymph node in the parapharyngeal space. Subsequent thyroidectomy identified a 4-mm papillary carcinoma in the thyroid gland. No other pathologic nodes in the neck were identified on MR imaging.

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    Fig 3.

    A 47-year-old woman with a history of thyroidectomy, bilateral neck dissections, and rising thyroglobulin levels. A, Gadolinium-enhanced axial T1-weighted MR image shows a 1-cm complex solid and cystic lymph node metastasis in the left retropharynx (arrowheads). B, Corresponding axial T2-weighted MR image shows the complex retropharyngeal node (arrows). C, CT-guided FNA reveals metastatic papillary cancer confirmed at surgical resection.

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    Fig 4.

    A 47-year-old woman treated with thyroidectomy and right neck dissection for papillary carcinoma presented with progressive rising thyroglobulin levels. A, Axial unenhanced T1-weighted MR image shows a 7-mm right retropharyngeal node (arrow) that is hyperintense relative to muscle. B, Axial T2-weighted MR image shows the node (arrow). Both FDG-PET and radioiodine showed increased uptake (not shown).

Tables

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  • Characteristics of patients with retropharyngeal or parapharyngeal space nodal metastases

    Age*/SexPrior SurgeryRP/PPS Node (Location/mm)MR SignalPETI-123FNA CytologySurgical Pathology
    47/FThyroidectomy, b/l neck dissectionLeft RP/10ComplexN/AN/APapillary thyroid ca.Papillary thyroid ca.
    68/FThyroidectomy, R neck dissectionRight RP/16SolidPosNegPapillary thyroid ca.Papillary thyroid ca.
    74/MThyroidectomy, L neck dissectionLeft RP/20ComplexN/ANegAnaplastic thyroid ca.N/A
    58/FThyroidectomy, L neck dissectionLeft RP/12SolidPosNegNo tumorPapillary thyroid ca.
    49/FThyroidectomy, L neck dissection, b/l paratracheal dissectionLeft RP/10SolidNegN/ANo tumorN/A
    52/FNoneRight PPS/25CysticN/AN/AN/APapillary thyroid ca.
    47/FThyroidectomy, R neck dissectionRight RP/7SolidNegNegN/AN/A
    47/FThyroidectomy, b/l neck dissection, posterior neck dissectionLeft RP/7SolidN/AN/AN/AN/A
    56/FThyroidectomy, R neck dissectionRight RP/11SolidN/AN/AN/AN/A
    • Note:—RP indicates retropharyngeal node; PPS, parapharyngeal space node; b/l, bilateral; L, left; R, right; Neg, negative; Pos, positive; N/A, not applicable; ca., cancer; PET, positron-emission tomography; FNA, fine needle aspiration.

    • * Age at identification of pathologic lymph node on MR imaging.

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American Journal of Neuroradiology: 30 (3)
American Journal of Neuroradiology
Vol. 30, Issue 3
March 2009
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Cite this article
S.L. Kaplan, S.J. Mandel, R. Muller, Z.W. Baloch, E.R. Thaler, L.A. Loevner
The Role of MR Imaging in Detecting Nodal Disease in Thyroidectomy Patients with Rising Thyroglobulin Levels
American Journal of Neuroradiology Mar 2009, 30 (3) 608-612; DOI: 10.3174/ajnr.A1405

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The Role of MR Imaging in Detecting Nodal Disease in Thyroidectomy Patients with Rising Thyroglobulin Levels
S.L. Kaplan, S.J. Mandel, R. Muller, Z.W. Baloch, E.R. Thaler, L.A. Loevner
American Journal of Neuroradiology Mar 2009, 30 (3) 608-612; DOI: 10.3174/ajnr.A1405
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