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Research ArticleBRAIN
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Temporoparietal MR Imaging Measures of Atrophy in Subjects with Mild Cognitive Impairment That Predict Subsequent Diagnosis of Alzheimer Disease

R.S. Desikan, H.J. Cabral, B. Fischl, C.R.G. Guttmann, D. Blacker, B.T. Hyman, M.S. Albert and R.J. Killiany
American Journal of Neuroradiology March 2009, 30 (3) 532-538; DOI: https://doi.org/10.3174/ajnr.A1397
R.S. Desikan
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H.J. Cabral
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B. Fischl
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C.R.G. Guttmann
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D. Blacker
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B.T. Hyman
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M.S. Albert
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R.J. Killiany
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    Fig 1.

    Illustration of the location of the inferior parietal and medial temporal regions of the brain on a 3D image on 1 hemisphere of the brain. Please see Fig 5 from Fischl et al, 200238 and Fig 1 from Desikan et al, 200637 for a detailed color depiction of all 16 temporoparietal regions of interest used in this study.

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    Fig 2.

    Survival curves for prediction of time to progression from MCI to a diagnosis of AD (based on the adjusted univariate model [shown at the mean, and 1 SD above and below the mean]), as a function of variation in the MR imaging volume of the inferior parietal lobule (A) and the entorhinal cortex (B).

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    Table 1:

    Descriptive statistical information for the subjects in the study*

    VariableTotal MCIMCI-ConvertersMCI-Nonconverters
    Sample size1294485
    Age (yr)72.4373.771.7
    (5.8)(5.4)(5.9)
    Education (yr)15.515.315.6
    (2.9)(3.0)(2.9)
    % female62.863.665.4
    MMSE29.128.729.3
    (1.2)(1.3)(1.1)
    CDR-SB1.31.61.2
    (0.8)(0.8)(0.8)
    % APOE-ε429.139.523.4
    Follow-up time (yr)6.25.06.9
    (4.2)(3.6)(4.4)
    • Note:—MCI indicates mild cognitive impairment; MMSE, Mini-Mental State Examination; CDR-SB, Clinical Dementia Rating sum of boxes; APOE, apolipoprotein E.

    • * Means are listed with SDs in parentheses.

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American Journal of Neuroradiology: 30 (3)
American Journal of Neuroradiology
Vol. 30, Issue 3
March 2009
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R.S. Desikan, H.J. Cabral, B. Fischl, C.R.G. Guttmann, D. Blacker, B.T. Hyman, M.S. Albert, R.J. Killiany
Temporoparietal MR Imaging Measures of Atrophy in Subjects with Mild Cognitive Impairment That Predict Subsequent Diagnosis of Alzheimer Disease
American Journal of Neuroradiology Mar 2009, 30 (3) 532-538; DOI: 10.3174/ajnr.A1397

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Temporoparietal MR Imaging Measures of Atrophy in Subjects with Mild Cognitive Impairment That Predict Subsequent Diagnosis of Alzheimer Disease
R.S. Desikan, H.J. Cabral, B. Fischl, C.R.G. Guttmann, D. Blacker, B.T. Hyman, M.S. Albert, R.J. Killiany
American Journal of Neuroradiology Mar 2009, 30 (3) 532-538; DOI: 10.3174/ajnr.A1397
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