Skip to main content
Advertisement

Main menu

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home

User menu

  • Alerts
  • Log in

Search

  • Advanced search
American Journal of Neuroradiology
American Journal of Neuroradiology

American Journal of Neuroradiology

ASHNR American Society of Functional Neuroradiology ASHNR American Society of Pediatric Neuroradiology ASSR
  • Alerts
  • Log in

Advanced Search

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home
  • Follow AJNR on Twitter
  • Visit AJNR on Facebook
  • Follow AJNR on Instagram
  • Join AJNR on LinkedIn
  • RSS Feeds

AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticleBRAIN
Open Access

Distinguishing Recurrent Intra-Axial Metastatic Tumor from Radiation Necrosis Following Gamma Knife Radiosurgery Using Dynamic Susceptibility-Weighted Contrast-Enhanced Perfusion MR Imaging

R.F. Barajas, J.S. Chang, P.K. Sneed, M.R. Segal, M.W. McDermott and S. Cha
American Journal of Neuroradiology February 2009, 30 (2) 367-372; DOI: https://doi.org/10.3174/ajnr.A1362
R.F. Barajas
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
J.S. Chang
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
P.K. Sneed
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
M.R. Segal
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
M.W. McDermott
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
S. Cha
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Supplemental
  • Info & Metrics
  • Responses
  • References
  • PDF
Loading

References

  1. ↵
    Mintz A, Perry J, Spithoff K, et al. Management of single brain metastasis: a practice guideline. Curr Oncol 2007;14:131–43
    CrossRefPubMed
  2. ↵
    Tsuruda JS, Kortman KE, Bradley WG, et al. Radiation effects on cerebral white matter: MR evaluation. AJR Am J Roentgenol 1987;149:165–71
    PubMedWeb of Science
  3. ↵
    Dooms GC, Hecht S, Brant-Zawadzki M, et al. Brain radiation lesions: MR imaging. Radiology 1986;158:149–55
    PubMedWeb of Science
  4. ↵
    Sugahara T, Korogi Y, Tomiguchi S, et al. Posttherapeutic intraaxial brain tumor: the value of perfusion-sensitive contrast-enhanced MR imaging for differentiating tumor recurrence from nonneoplastic contrast-enhancing tissue. AJNR Am J Neuroradiol 2000;21:901–09
    Abstract/FREE Full Text
  5. ↵
    Cha S, Lupo JM, Chen MH, et al. Differentiation of glioblastoma multiforme and single brain metastasis by peak height and percentage of signal intensity recovery derived from dynamic susceptibility-weighted contrast-enhanced perfusion MR imaging. AJNR Am J Neuroradiol 2007;28:1078–84
    Abstract/FREE Full Text
  6. ↵
    Lupo JM, Cha S, Chang SM, et al. Dynamic susceptibility-weighted perfusion imaging of high-grade gliomas: characterization of spatial heterogeneity. AJNR Am J Neuroradiol 2005;26:1446–54
    Abstract/FREE Full Text
  7. Essig M, Waschkies M, Wenz F, et al. Assessment of brain metastases with dynamic susceptibility-weighted contrast-enhanced MR imaging: initial results. Radiology 2003;228:193–99
    PubMed
  8. Sugahara T, Korogi Y, Kochi M, et al. Correlation of MR imaging-determined cerebral blood volume maps with histologic and angiographic determination of vascularity of gliomas. AJR Am J Roentgenol 1998;171:1479–86
    CrossRefPubMedWeb of Science
  9. Lev MH, Ozsunar Y, Henson JW, et al. Glial tumor grading and outcome prediction using dynamic spin-echo MR susceptibility mapping compared with conventional contrast-enhanced MR: confounding effect of elevated rCBV of oligodendrogliomas. AJNR Am J Neuroradiol 2004;25:214–21
    Abstract/FREE Full Text
  10. Cha S, Lu S, Johnson G, et al. Dynamic susceptibility contrast MR imaging: correlation of signal intensity changes with cerebral blood volume measurements. J Magn Reson Imaging 2000;11:114–19
    CrossRefPubMed
  11. Aronen HJ, Gazit IE, Louis DN, et al. Cerebral blood volume maps of gliomas: comparison with tumor grade and histologic findings. Radiology 1994;191:41–51
    PubMedWeb of Science
  12. ↵
    Law M, Cha S, Knopp EA, et al. High-grade gliomas and solitary metastases: differentiation by using perfusion and proton spectroscopic MR imaging. Radiology 2002;222:715–21
    PubMedWeb of Science
  13. ↵
    Oh BC, Liu CY, Wang MY, et al. Stereotactic radiosurgery: adjacent tissue injury and response after high-dose single fraction radiation. Part 1. Histology, imaging, and molecular events. Neurosurgery 2007;60:31–45
    PubMed
  14. ↵
    Kamiryo T, Lopes MB, Kassell NF, et al. Radiosurgery-induced microvascular alterations precede necrosis of the brain neuropil. Neurosurgery 2001;49:409–15
    CrossRefPubMedWeb of Science
  15. ↵
    Long DM. Capillary ultrastructure in human metastatic brain tumors. J Neurosurg 1979;51:53–58
    PubMedWeb of Science
  16. Remler MP, Marcussen WH, Tiller-Borsich J. The late effects of radiation on the blood brain barrier. Int J Radiat Oncol Biol Phys 1986;12:1965–69
    CrossRefPubMed
  17. Jinnouchi T, Shibata S, Fukushima M, et al. Ultrastructure of capillary permeability in human brain tumor. Part 6. Metastatic brain tumor with brain edema [in Japanese]. No Shinkei Geka 1988;16 (5 suppl):563–68
    PubMed
  18. ↵
    Spiegelmann R; Friedmann WA, Bova FJ, et al. LINAC radiosurgery: an animal model. J Neurosurg 1993;78:638–44
    PubMed
  19. ↵
    Breiman L, Friedman JH, Olshen RA, et al. Classification and Regression Trees. Belmont, Calif: Wadsworth;1984
  20. ↵
    The R Project for Statistical Computing. Available at: http://www.R-project.org. Accessed February2008
  21. ↵
    Chao S, Suh J, Raja S, et al. The sensitivity and specificity of FDG PET in distinguishing recurrent brain tumor from radionecrosis in patients treated with stereotactic radiosurgery. Int J Cancer 2001;96:191–97
    CrossRefPubMedWeb of Science
  22. Ericson K, Kihlström L, Mogard J, et al. Positron emission tomography using 18F-fluorodeoxyglucose in patients with stereotactically irradiated brain metastases. Stereotact Funct Neurosurg 1996;66 (suppl 1):214–24
    CrossRefPubMed
  23. ↵
    Petronas NJ, DiChiro G, Brooks RA, et al. Work in progress: [18F] fluorodeoxyglucose and positron emission tomography in the evaluation of radiation necrosis of the brain. Radiology 1982;144:885–89
    PubMedWeb of Science
  24. ↵
    Griffeth LK, Rich KM, Dehdashti F, et al. Brain metastases from non-central nervous system tumors: evaluation with PET. Radiology 1993;186:37–44
    PubMedWeb of Science
  25. ↵
    Kahn D, Follett KA, Bushnell DL, et al. Diagnosis of recurrent brain tumor: value of 201Tl SPECT vs 18F-fluorodeoxyglucose PET. AJR Am J Roentgenol 1994;163:1459–65
    CrossRefPubMed
  26. ↵
    Graves E, Nelson S, Vigneron D, et al. Serial proton MR spectroscopic imaging of recurrent malignant gliomas after gamma knife radiosurgery. AJNR Am J Neuroradiol 2001;22:613–24
    Abstract/FREE Full Text
  27. ↵
    Schlemmer H, Bachert P, Herfarth K, et al. Proton MR spectroscopic evaluation of suspicious brain lesions after stereotactic radiotherapy. AJNR Am J Neuroradiol 2001;22:1316–24
    Abstract/FREE Full Text
  28. Hein P, Eskey C, Dunn J, et al. Diffusion-weighted imaging in the follow-up of treated high-grade gliomas: tumor recurrence versus radiation injury. AJNR Am J Neuroradiol 2004;25:201–09
    Abstract/FREE Full Text
  29. ↵
    Hollingworth W, Medina L, Lenkinski R, et al. A systematic literature review of magnetic resonance spectroscopy for the characterization of brain tumors. AJNR Am J Neuroradiol 2006;27:1404–11
    Abstract/FREE Full Text
  30. ↵
    Lupo JM, Lee MC, Han ET, et al. Feasibility of dynamic susceptibility contrast perfusion MR imaging at 3T using a standard quadrature head coil and eight-channel phased-array coil with and without SENSE reconstruction. J Magn Reson Imaging 2006;24:520–29
    CrossRefPubMed
PreviousNext
Back to top

In this issue

American Journal of Neuroradiology: 30 (2)
American Journal of Neuroradiology
Vol. 30, Issue 2
February 2009
  • Table of Contents
  • Index by author
Advertisement
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on American Journal of Neuroradiology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Distinguishing Recurrent Intra-Axial Metastatic Tumor from Radiation Necrosis Following Gamma Knife Radiosurgery Using Dynamic Susceptibility-Weighted Contrast-Enhanced Perfusion MR Imaging
(Your Name) has sent you a message from American Journal of Neuroradiology
(Your Name) thought you would like to see the American Journal of Neuroradiology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Cite this article
R.F. Barajas, J.S. Chang, P.K. Sneed, M.R. Segal, M.W. McDermott, S. Cha
Distinguishing Recurrent Intra-Axial Metastatic Tumor from Radiation Necrosis Following Gamma Knife Radiosurgery Using Dynamic Susceptibility-Weighted Contrast-Enhanced Perfusion MR Imaging
American Journal of Neuroradiology Feb 2009, 30 (2) 367-372; DOI: 10.3174/ajnr.A1362

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
0 Responses
Respond to this article
Share
Bookmark this article
Distinguishing Recurrent Intra-Axial Metastatic Tumor from Radiation Necrosis Following Gamma Knife Radiosurgery Using Dynamic Susceptibility-Weighted Contrast-Enhanced Perfusion MR Imaging
R.F. Barajas, J.S. Chang, P.K. Sneed, M.R. Segal, M.W. McDermott, S. Cha
American Journal of Neuroradiology Feb 2009, 30 (2) 367-372; DOI: 10.3174/ajnr.A1362
del.icio.us logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Purchase

Jump to section

  • Article
    • Abstract
    • Materials and Methods
    • Results
    • Discussion
    • Conclusions
    • Acknowledgments
    • Footnotes
    • References
  • Figures & Data
  • Supplemental
  • Info & Metrics
  • Responses
  • References
  • PDF

Related Articles

  • PubMed
  • Google Scholar

Cited By...

  • DSC MR Perfusion at 7T MRI: An Initial Single-Center Study for Validity and Practicability
  • DSC Perfusion MRI-Derived Fractional Tumor Burden and Relative CBV Differentiate Tumor Progression and Radiation Necrosis in Brain Metastases Treated with Stereotactic Radiosurgery
  • Postcontrast T1 Mapping for Differential Diagnosis of Recurrence and Radionecrosis after Gamma Knife Radiosurgery for Brain Metastasis
  • Differentiation between Radiation Necrosis and Tumor Progression Using Chemical Exchange Saturation Transfer
  • Classification of High-Grade Glioma into Tumor and Nontumor Components Using Support Vector Machine
  • Current Applications of MRI-Guided Laser Interstitial Thermal Therapy in the Treatment of Brain Neoplasms and Epilepsy: A Radiologic and Neurosurgical Overview
  • ASFNR Recommendations for Clinical Performance of MR Dynamic Susceptibility Contrast Perfusion Imaging of the Brain
  • Diffusion and Perfusion MRI to Differentiate Treatment-Related Changes Including Pseudoprogression from Recurrent Tumors in High-Grade Gliomas with Histopathologic Evidence
  • Utility of Intravoxel Incoherent Motion MR Imaging for Distinguishing Recurrent Metastatic Tumor from Treatment Effect following Gamma Knife Radiosurgery: Initial Experience
  • Phase II Study of Bevacizumab, Temozolomide, and Hypofractionated Stereotactic Radiotherapy for Newly Diagnosed Glioblastoma
  • The Effect of Pulse Sequence Parameters and Contrast Agent Dose on Percentage Signal Recovery in DSC-MRI: Implications for Clinical Applications
  • Role of O-(2-18F-Fluoroethyl)-L-Tyrosine PET for Differentiation of Local Recurrent Brain Metastasis from Radiation Necrosis
  • Perfusion CT Imaging of Brain Tumors: An Overview
  • Percentage Signal Recovery Derived from MR Dynamic Susceptibility Contrast Imaging Is Useful to Differentiate Common Enhancing Malignant Lesions of the Brain
  • Permeability Estimates in Histopathology-Proved Treatment-Induced Necrosis Using Perfusion CT: Can These Add to Other Perfusion Parameters in Differentiating from Recurrent/Progressive Tumors?
  • MR Spectroscopy in Radiation Injury
  • Crossref (221)
  • Google Scholar

This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.

  • Differentiation of Recurrent Glioblastoma Multiforme from Radiation Necrosis after External Beam Radiation Therapy with Dynamic Susceptibility-weighted Contrast-enhanced Perfusion MR Imaging
    Ramon F. Barajas, Jamie S. Chang, Mark R. Segal, Andrew T. Parsa, Michael W. McDermott, Mitchel S. Berger, Soonmee Cha
    Radiology 2009 253 2
  • Differentiating tumor recurrence from treatment necrosis: a review of neuro-oncologic imaging strategies
    Nishant Verma, Matthew C. Cowperthwaite, Mark G. Burnett, Mia K. Markey
    Neuro-Oncology 2013 15 5
  • Long-term risk of radionecrosis and imaging changes after stereotactic radiosurgery for brain metastases
    Zachary A. Kohutek, Yoshiya Yamada, Timothy A. Chan, Cameron W. Brennan, Viviane Tabar, Philip H. Gutin, T. Jonathan Yang, Marc K. Rosenblum, Åse Ballangrud, Robert J. Young, Zhigang Zhang, Kathryn Beal
    Journal of Neuro-Oncology 2015 125 1
  • Radiation Necrosis in the Brain: Imaging Features and Differentiation from Tumor Recurrence
    Ritu Shah, Surjith Vattoth, Rojymon Jacob, Fathima Fijula Palot Manzil, Janis P. O’Malley, Peyman Borghei, Bhavik N. Patel, Joel K. Curé
    RadioGraphics 2012 32 5
  • ASFNR Recommendations for Clinical Performance of MR Dynamic Susceptibility Contrast Perfusion Imaging of the Brain
    K. Welker, J. Boxerman, A. Kalnin, T. Kaufmann, M. Shiroishi, M. Wintermark
    American Journal of Neuroradiology 2015 36 6
  • Regional variation in histopathologic features of tumor specimens from treatment-naive glioblastoma correlates with anatomic and physiologic MR Imaging
    R. F. Barajas, J. J. Phillips, R. Parvataneni, A. Molinaro, E. Essock-Burns, G. Bourne, A. T. Parsa, M. K. Aghi, M. W. McDermott, M. S. Berger, S. Cha, S. M. Chang, S. J. Nelson
    Neuro-Oncology 2012 14 7
  • Consensus recommendations for a standardized brain tumor imaging protocol for clinical trials in brain metastases
    Timothy J Kaufmann, Marion Smits, Jerrold Boxerman, Raymond Huang, Daniel P Barboriak, Michael Weller, Caroline Chung, Christina Tsien, Paul D Brown, Lalitha Shankar, Evanthia Galanis, Elizabeth Gerstner, Martin J van den Bent, Terry C Burns, Ian F Parney, Gavin Dunn, Priscilla K Brastianos, Nancy U Lin, Patrick Y Wen, Benjamin M Ellingson
    Neuro-Oncology 2020 22 6
  • Pseudoprogression, radionecrosis, inflammation or true tumor progression? challenges associated with glioblastoma response assessment in an evolving therapeutic landscape
    Benjamin M. Ellingson, Caroline Chung, Whitney B. Pope, Jerrold L. Boxerman, Timothy J. Kaufmann
    Journal of Neuro-Oncology 2017 134 3
  • Diagnosis and Management of Radiation Necrosis in Patients With Brain Metastases
    Balamurugan Vellayappan, Char Loo Tan, Clement Yong, Lih Kin Khor, Wee Yao Koh, Tseng Tsai Yeo, Jay Detsky, Simon Lo, Arjun Sahgal
    Frontiers in Oncology 2018 8
  • Modern Brain Tumor Imaging
    Marc C. Mabray, Ramon F. Barajas, Soonmee Cha
    Brain Tumor Research and Treatment 2015 3 1

More in this TOC Section

  • Multimodal CT Provides Improved Performance for Lacunar Infarct Detection
  • Optimal MRI Sequence for Identifying Occlusion Location in Acute Stroke: Which Value of Time-Resolved Contrast-Enhanced MRA?
  • Evaluating the Effects of White Matter Multiple Sclerosis Lesions on the Volume Estimation of 6 Brain Tissue Segmentation Methods
Show more BRAIN

Similar Articles

Advertisement

Indexed Content

  • Current Issue
  • Accepted Manuscripts
  • Article Preview
  • Past Issues
  • Editorials
  • Editor's Choice
  • Fellows' Journal Club
  • Letters to the Editor
  • Video Articles

Cases

  • Case Collection
  • Archive - Case of the Week
  • Archive - Case of the Month
  • Archive - Classic Case

More from AJNR

  • Trainee Corner
  • Imaging Protocols
  • MRI Safety Corner
  • Book Reviews

Multimedia

  • AJNR Podcasts
  • AJNR Scantastics

Resources

  • Turnaround Time
  • Submit a Manuscript
  • Submit a Video Article
  • Submit an eLetter to the Editor/Response
  • Manuscript Submission Guidelines
  • Statistical Tips
  • Fast Publishing of Accepted Manuscripts
  • Graphical Abstract Preparation
  • Imaging Protocol Submission
  • Evidence-Based Medicine Level Guide
  • Publishing Checklists
  • Author Policies
  • Become a Reviewer/Academy of Reviewers
  • News and Updates

About Us

  • About AJNR
  • Editorial Board
  • Editorial Board Alumni
  • Alerts
  • Permissions
  • Not an AJNR Subscriber? Join Now
  • Advertise with Us
  • Librarian Resources
  • Feedback
  • Terms and Conditions
  • AJNR Editorial Board Alumni

American Society of Neuroradiology

  • Not an ASNR Member? Join Now

© 2025 by the American Society of Neuroradiology All rights, including for text and data mining, AI training, and similar technologies, are reserved.
Print ISSN: 0195-6108 Online ISSN: 1936-959X

Powered by HighWire