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Research ArticleMethodologic Perspectives

A Proposed Methodology to Select Radioisotopes for Use in Radionuclide Therapy

J.J. Cuaron, J.A. Hirsch, D.C. Medich, B.S. Rosenstein, C.B. Martel and A.E. Hirsch
American Journal of Neuroradiology November 2009, 30 (10) 1824-1829; DOI: https://doi.org/10.3174/ajnr.A1773
J.J. Cuaron
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J.A. Hirsch
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D.C. Medich
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B.S. Rosenstein
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C.B. Martel
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A.E. Hirsch
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    Fig 1.

    The factors influencing the suitability of a radionuclide for use in radiation therapy.

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    Fig 2.

    After defining the therapeutic need, the provider should use a well-organized collection of information that determines radionuclide suitability by evaluating numerous isotopic characteristics. This allows more informed radionuclide selection.

Tables

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  • Summary of the radiologic characteristics for the isotopes studied in Hirsch et al3

    RadioisotopeT1/2Decay ModeDecay Summary
    32P14.29 daysβ−Eavg = 694 keV, Emax = 1710 keV, (Rcsdamax)bone = 4.75 mm
    166Ho26.8 hoursβ−Eavg = 666 keV, Emax = 1854 keV, (Rcsdamax)bone = 5.20 mm
    90Yb64.1 hoursβ−Eavg = 934 keV, Emax = 2284 keV, (Rcsdamax)bone = 6.51 mm
    125I59.3 daysεEavg = 28 keV, Yγ = 159.6%
    18F110 moβ+Eavg = 633.5 keV, Emax = 249.8 keV, (Rcsdamax)bone = 1.0 mm; produces 511 keV annihilation photons, Yγ = 96.73%
    99mTc6.01 hoursITEavg = 131 keV, Yγ = 96.5%
    • Note:—32P indicates phosphorus-32; 166Ho, holmium-166; 90Yb, yttrium-90; 125I, iodine 125; 18F, fluorine-18; 99mTc, technetium-Tc99m; ε, low energy photon; T1/2, half-life; IT, mid energy photon; Eavg, average energy; Emax, max energy; (Rcsdamax)bone, continuous-slowing-down-approximation of maximum range in bone; Yγ, gamma photon yield.

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American Journal of Neuroradiology: 30 (10)
American Journal of Neuroradiology
Vol. 30, Issue 10
1 Nov 2009
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A Proposed Methodology to Select Radioisotopes for Use in Radionuclide Therapy
J.J. Cuaron, J.A. Hirsch, D.C. Medich, B.S. Rosenstein, C.B. Martel, A.E. Hirsch
American Journal of Neuroradiology Nov 2009, 30 (10) 1824-1829; DOI: 10.3174/ajnr.A1773
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Cite this article
J.J. Cuaron, J.A. Hirsch, D.C. Medich, B.S. Rosenstein, C.B. Martel, A.E. Hirsch
A Proposed Methodology to Select Radioisotopes for Use in Radionuclide Therapy
American Journal of Neuroradiology Nov 2009, 30 (10) 1824-1829; DOI: 10.3174/ajnr.A1773

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