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Improved Turnaround Times | Median time to first decision: 12 days

Research ArticleNeurointervention

The Penumbra System: A Mechanical Device for the Treatment of Acute Stroke due to Thromboembolism

A. Bose, H. Henkes, K. Alfke, W. Reith, T.E. Mayer, A. Berlis, V. Branca and S. Po Sit for the Penumbra Phase 1 Stroke Trial Investigators
American Journal of Neuroradiology August 2008, 29 (7) 1409-1413; DOI: https://doi.org/10.3174/ajnr.A1110
A. Bose
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H. Henkes
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K. Alfke
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W. Reith
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T.E. Mayer
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A. Berlis
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V. Branca
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S. Po Sit
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References

  1. ↵
    Jansen O, von Kummer R, Forsting M, et al. Thrombolytic therapy in acute occlusion of the intracranial internal carotid artery bifurcation. AJNR Am J Neuroradiol 1995;16:1977–86
    Abstract
  2. Brandt T, von Kummer R, Muller-Kuppers M, et al. Thrombolytic therapy of acute basilar artery occlusion. Stroke 1996;27:875–81
    Abstract/FREE Full Text
  3. ↵
    Eckert B, Koch C, Thomalla G, et al. Aggressive therapy with intravenous abcizimab and intra-arterial rtPA and additional PTA/stenting improves clinical outcome in acute vertebrobasilar occlusion: combined local fibrinolysis and intravenous abciximab in acute vertebrobasilar stroke treatment (FAST): results of a multicenter study. Stroke 2005;36:1160–65
    Abstract/FREE Full Text
  4. ↵
    Jansen O, Schellinger P, Fiebach J, et al. Early revascularization in acute ischemic stroke saves tissue at risk defined by MRI. Lancet 1997;353:2036–37
    CrossRef
  5. ↵
    Leary M, Saver S, Gobin Y, et al. Beyond tissue plasminogen activator: mechanical intervention in acute stroke. Ann Emerg Med 2003;41:838–46
    CrossRefPubMed
  6. ↵
    Gomez CR, Orr SC, Soto RD. Neuroendovascular rescue: Interventional treatment of acute ischemic stroke. Curr Treat Options Cardiovasc Med 2002;4:405–19
    PubMed
  7. ↵
    Thrombolysis in Myocardial Infarction (TIMI) Trial: phase 1 findings –TIMI Study Group. N Engl J Med 1985;312:932–36
    PubMed
  8. ↵
    Khatri P, Wechsler LR, Broderick JP. Intracranial hemorrhage associated with revascularization therapies. Stroke 2007;38:431–40
    Abstract/FREE Full Text
  9. ↵
    The National Institute of Neurological Disorders and Stroke t-PA Stroke Study Group. Tissue plasminogen activator for acute ischemic stroke. N Engl J Med 1995;333:1581–87
    CrossRefPubMedWeb of Science
  10. ↵
    Furlan A, Higashida R, Wechsler L, et al. Intra-arterial prourokinase for acute ischemic stroke. The PROACT II Study: a randomized controlled trial. JAMA 1999;282:2003–11
    CrossRefPubMedWeb of Science
  11. ↵
    Smith WS, Sung G, Starkman S, et al. Safety and efficacy of mechanical embolectomy in acute ischemic stroke: results of the MERCI trial. Stroke 2005;36:1432–38
    Abstract/FREE Full Text
  12. ↵
    Smith WS. Safety of mechanical thrombectomy and intravenous tissue plasminogen activator in acute ischemic stroke. Results of the multi Mechanical Embolus Removal in Cerebral Ischemia (MERCI) trial, part I. AJNR Am J Neuroradiol 2006;27:1177–82
    Abstract/FREE Full Text
  13. ↵
    Gobin YP, Starkman S, Duckwiler GR, et al. MERCI 1: a phase 1 study of mechanical embolus removal in cerebral ischemia. Stroke 2004;35:2848–54
    Abstract/FREE Full Text
  14. ↵
    Ogawa A, Mori E, Minematsu K, et al. Randomized trial of intraarterial infusion of urokinase within 6 hours of middle cerebral artery stroke. The middle cerebral artery embolism local fibrinolytic intervention trial (MELT) Japan. Stroke 2007;38:2633–39
    Abstract/FREE Full Text
  15. Saver JL. Intra-arterial fibrinolysis for acute ischemic stroke. The message of MELT. Stroke 2007;38:2627–28
    FREE Full Text
  16. ↵
    IMS Trial Investigators. Combined intravenous and intra-arterial revascularization for acute ischemic stroke: the interventional management of stroke study. Stroke 2004;35:904–11
    Abstract/FREE Full Text
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American Journal of Neuroradiology: 29 (7)
American Journal of Neuroradiology
Vol. 29, Issue 7
August 2008
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A. Bose, H. Henkes, K. Alfke, W. Reith, T.E. Mayer, A. Berlis, V. Branca, S. Po Sit
The Penumbra System: A Mechanical Device for the Treatment of Acute Stroke due to Thromboembolism
American Journal of Neuroradiology Aug 2008, 29 (7) 1409-1413; DOI: 10.3174/ajnr.A1110

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The Penumbra System: A Mechanical Device for the Treatment of Acute Stroke due to Thromboembolism
A. Bose, H. Henkes, K. Alfke, W. Reith, T.E. Mayer, A. Berlis, V. Branca, S. Po Sit
American Journal of Neuroradiology Aug 2008, 29 (7) 1409-1413; DOI: 10.3174/ajnr.A1110
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