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Research ArticleFUNCTIONAL

Extent of Microstructural White Matter Injury in Postconcussive Syndrome Correlates with Impaired Cognitive Reaction Time: A 3T Diffusion Tensor Imaging Study of Mild Traumatic Brain Injury

S.N. Niogi, P. Mukherjee, J. Ghajar, C. Johnson, R.A. Kolster, R. Sarkar, H. Lee, M. Meeker, R.D. Zimmerman, G.T. Manley and B.D. McCandliss
American Journal of Neuroradiology May 2008, 29 (5) 967-973; DOI: https://doi.org/10.3174/ajnr.A0970
S.N. Niogi
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P. Mukherjee
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J. Ghajar
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C. Johnson
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R.A. Kolster
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R. Sarkar
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H. Lee
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M. Meeker
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R.D. Zimmerman
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G.T. Manley
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B.D. McCandliss
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    Fig 1.

    Region-of-interest placement for DTI analysis. Shown are corresponding regions of interest for the right hemisphere. The solid ellipse within the white outline indicates the location and size of the region of interest. A, Middle cerebral peduncle. B, Pontine crossing tract. C, Superior cerebellar peduncle. D, Decussation of the superior cerebellar peduncle. E, Cerebral peduncle. F, Anterior inferior longitudinal fasciculi. G, Posterior inferior longitudinal fasciculi. H, Uncinate fasciculus. I, Genu of the corpus callosum. J, Forceps minor. K, Forceps major. L, Posterior limb of the internal capsule. M, Anterior limb of internal capsule. N, Splenium of the corpus callosum. O, Body of the corpus callosum. P, Superior corona radiata. Q, Anterior corona radiata. R, Superior longitudinal fasciculus at level of the body of the corpus callosum. S, Superior longitudinal fasciculus at level of cingulum bundle. T, Cingulum bundle. U, Anterior centrum semiovale. V, Posterior centrum semiovale. Regions of interest were placed on both cerebral hemispheres when applicable, resulting in a total of 39 regions of interest per subject.

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    Fig 2.

    A, Correlation of the number of damaged white matter tracts and speed of processing. The correlation is statistically significant (P = .012) with r = 0.49. B, In contradistinction, the corresponding analysis, by using conventional MR imaging of the number of traumatic microhemorrhages correlated with speed of processing, is not statistically significant (r = −0.08, P = .70).

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American Journal of Neuroradiology: 29 (5)
American Journal of Neuroradiology
Vol. 29, Issue 5
May 2008
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S.N. Niogi, P. Mukherjee, J. Ghajar, C. Johnson, R.A. Kolster, R. Sarkar, H. Lee, M. Meeker, R.D. Zimmerman, G.T. Manley, B.D. McCandliss
Extent of Microstructural White Matter Injury in Postconcussive Syndrome Correlates with Impaired Cognitive Reaction Time: A 3T Diffusion Tensor Imaging Study of Mild Traumatic Brain Injury
American Journal of Neuroradiology May 2008, 29 (5) 967-973; DOI: 10.3174/ajnr.A0970

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Extent of Microstructural White Matter Injury in Postconcussive Syndrome Correlates with Impaired Cognitive Reaction Time: A 3T Diffusion Tensor Imaging Study of Mild Traumatic Brain Injury
S.N. Niogi, P. Mukherjee, J. Ghajar, C. Johnson, R.A. Kolster, R. Sarkar, H. Lee, M. Meeker, R.D. Zimmerman, G.T. Manley, B.D. McCandliss
American Journal of Neuroradiology May 2008, 29 (5) 967-973; DOI: 10.3174/ajnr.A0970
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