The Modic Vertebral Endplate and Marrow Changes: Pathologic Significance and Relation to Low Back Pain and Segmental Instability of the Lumbar Spine

References

1. ↵
   de Roos A, Kressel H, Spritzer C, et al. MR imaging of marrow changes adjacent to end plates in degenerative lumbar disk disease. AJR Am J Roentgenol 1987;149:531–34

   PubMedWeb of Science
2. ↵
   Modic MT, Steinberg PM, Ross JS, et al. Degenerative disk disease: assessment of changes in vertebral body marrow with MR imaging. Radiology 1988;166:193–99

   PubMedWeb of Science
3. ↵
   Modic MT, Masaryk TJ, Ross JS, et al. Imaging of degenerative disk disease. Radiology 1988;168:177–86

   PubMedWeb of Science
4. ↵
   Braithwaite I, White J, Saifuddin A, et al. Vertebral end-plate (Modic) changes on lumbar spine MRI: correlation with pain reproduction at lumbar discography. Eur Spine J 1998;7:363–68

   CrossRefPubMed
5. ↵
   Marshman LA, Trewhella M, Friesem T, et al. Reverse transformation of Modic type 2 changes to Modic type 1 changes during sustained chronic low-back pain severity: report of two cases and review of the literature. J Neurosurg Spine 2007;6:152–55

   CrossRefPubMed
6. ↵
   Toyone T, Takahashi K, Kitahara H, et al. Vertebral bone-marrow changes in degenerative lumbar disc disease: an MRI study of 74 patients with low back pain. J Bone Joint Surg Br 1994;76:757–64

   PubMed
7. ↵
   Weishaupt D, Zanetti M, Hodler J, et al. Painful lumbar disk derangement: relevance of endplate abnormalities at MR imaging. Radiology 2001;218:420–27

   PubMed
8. ↵
   Mitra D, Cassar-Pullicino VN, McCall IW. Longitudinal study of vertebral type-1 end-plate changes on MR of the lumbar spine. Eur Radiol 2004;14:1574–81

   PubMedWeb of Science
9. ↵
   Schmid G, Witteler A, Willburger R, et al. Lumbar disk herniation: correlation of histologic findings with marrow signal intensity changes in vertebral endplates at MR imaging. Radiology 2004;231:352–58

   CrossRefPubMed
10. ↵
    Karchevsky M, Schweitzer ME, Carrino JA, et al. Reactive endplate marrow changes: a systematic morphologic and epidemiologic evaluation. Skeletal Radiol 2005;34:125–29

    CrossRefPubMedWeb of Science
11. ↵
    Kjaer P, Leboeuf-Yde C, Korsholm L, et al. Magnetic resonance imaging and low back pain in adults: a diagnostic imaging study of 40-year-old men and women. Spine 2005;30:1173–80

    CrossRefPubMedWeb of Science
12. ↵
    Kuisma M, Karppinen J, Niinimaki J, et al. A three-year follow-up of lumbar spine endplate (Modic) changes. Spine 2006;31:1714–18

    CrossRefPubMedWeb of Science
13. ↵
    Kuisma M, Karppinen J, Niinimäki J, et al. Modic changes in endplates of lumbar vertebral bodies: prevalence and association with low back and sciatic pain among middle-aged male workers. Spine 2007;32:1116–22

    CrossRefPubMedWeb of Science
14. ↵
    Albert HB, Manniche C. Modic changes following lumbar disc herniation. Eur Spine J 2007;16:977–82

    CrossRefPubMedWeb of Science
15. ↵
    Modic MT. Modic type 1 and type 2 changes. J Neurosurg Spine 2007;6:150–51

    CrossRefPubMed
16. ↵
    Weishaupt D, Zanetti M, Hodler J, et al. MR imaging of the lumbar spine: prevalence of intervertebral disk extrusion and sequestration, nerve root compression, end plate abnormalities, and osteoarthritis of the facet joints in asymptomatic volunteers. Radiology 1998;209:661–66

    PubMedWeb of Science
17. ↵
    Kjaer P, Korsholm L, Bendix T, et al. Modic changes and their associations with clinical findings. Eur Spine J 2006;15:1312–19

    CrossRefPubMedWeb of Science
18. ↵
    James SL, Davies AM. Imaging of infectious spinal disorders in children and adults. Eur J Radiol 2006;58:27–40

    CrossRefPubMed
19. ↵
    Ross JS, Modic MT. Current assessment of spinal degenerative disease with magnetic resonance imaging. Clin Orthop Relat Res 1992;279:68–81

    PubMed
20. ↵
    Van Goethem JW, Parizel PM, van den Hauwe L, et al. The value of MRI in the diagnosis of postoperative spondylodiskitis. Neuroradiology 2000;42:580–85

    CrossRefPubMedWeb of Science
21. ↵
    Ledermann HP, Schweitzer ME, Morrison WB, et al. MR imaging findings in spinal infections: rules or myths? Radiology 2003;228:506–14

    PubMedWeb of Science
22. ↵
    Kokkonen SM, Kurunlahti M, Tervonen O, et al. Endplate degeneration observed on magnetic resonance imaging of the lumbar spine: correlation with pain provocation and disc changes observed on computed tomography diskography. Spine 2002;27:2274–78

    CrossRefPubMedWeb of Science
23. ↵
    Crock HV. Internal disc disruption: a challenge to disc prolapse fifty years on. Spine 1986;11:650–53

    CrossRefPubMedWeb of Science
24. ↵
    Brown MF, Hukkanen MV, McCarthy ID, et al. Sensory and sympathetic innervation of the vertebral endplate in patients with degenerative disc disease. J Bone Joint Surg Br 1997;79:147–53

    CrossRefPubMed
25. ↵
    Burke JG, Watson RW, McCormack D, et al. Intervertebral discs which cause low back pain secrete high levels of proinflammatory mediators. J Bone Joint Surg Br 2002;84:196–201

    CrossRefPubMed
26. ↵
    Vital JM, Gille O, Pointillart V, et al. Course of Modic 1 six months after lumbar posterior osteosynthesis. Spine 2003;28:715–21

    CrossRefPubMed
27. ↵
    Ohtori S, Inoue G, Ito T, et al. Tumor necrosis factor-immunoreactive cells and PGP 9.5-immunoreactive nerve fibers in vertebral endplates of patients with discogenic low back pain and Modic type 1 or type 2 changes on MRI. Spine 2006;31:1026–31

    CrossRefPubMed
28. ↵
    Korhonen T, Karppinen J, Paimela L, et al. The treatment of disc-herniation-induced sciatica with infliximab: one-year follow-up results of FIRST II, a randomized controlled trial. Spine 2006;31:2759–66

    CrossRefPubMedWeb of Science
29. ↵
    Fayad F, Lefevre-Colau MM, Rannou F, et al. Relation of inflammatory Modic changes to intradiscal steroid injection outcome in chronic low back pain. Eur Spine J 2007;16:925–31

    CrossRefPubMed
30. ↵
    Sandhu HS, Sanchez-Caso LP, Parvataneni HK, et al. Association between findings of provocative discography and vertebral endplate signal changes as seen on MRI. J Spinal Disord 2000;13:438–43

    CrossRefPubMed
31. ↵
    Bräm J, Zanetti M, Min K, et al. MR abnormalities of the intervertebral disks and adjacent bone marrow as predictors of segmental instability of the lumbar spine. Acta Radiol 1998;39:18–23

    PubMed
32. ↵
    Nizard RS, Wybier M, Laredo JD. Radiologic assessment of lumbar intervertebral instability and degenerative spondylolisthesis. Radiol Clin North Am 2001;39:55–71

    CrossRefPubMedWeb of Science
33. ↵
    Lang P, Chafetz N, Genant HK, et al. Lumbar spinal fusion: assessment of functional stability with magnetic resonance imaging. Spine 1990;15:581–88

    PubMedWeb of Science
34. ↵
    Buttermann GR, Heithoff KB, Ogilvie JW, et al. Vertebral body MRI related to lumbar fusion results. Eur Spine J 1997;6:115–20

    CrossRefPubMed
35. ↵
    Chataigner H, Onimus M, Polette A. Surgery for degenerative lumbar disc disease: should the black disc be grafted [in French]? Rev Chir Orthop Reparatrice Appar Mot 1998;84:583–89

    PubMed
36. ↵
    Esposito P, Pinheiro-Franco JL, Froelich S, et al.. Predictive value of MRI vertebral end-plate signal changes (Modic) on outcome of surgically treated degenerative disc disease: results of a cohort study including 60 patients. Neurochirurgie 2006;52:315–22

    CrossRefPubMedWeb of Science