Article Figures & Data
Figures
- Fig 1.
Box and whisker graph showing PS (A) and CBV (B) for low-versus-high-grade astroglial tumors.
- Fig 2.
A and B, Postcontrast T1-weighted (TR/TE, 3059/6.35 ms) axial image (A) and base image from perfusion CT study (B) in 32-year-old woman with WHO grade II astrocytoma showing a nonenhancing right frontal tumor with no surrounding perilesional edema. C and D, PS (C) and CBV (D) perfusion CT maps showing low permeability (PS = 0.7 mL/100 g per minute) and low blood volume (CBV = 1.01 mL/100 g) within the tumor.
- Fig 3.
A, Postcontrast T1-weighted (TR/TE, 3218/5.71 ms) axial image in a 55-year-old man with glioblastoma multiforme showing a heterogeneously enhancing mass with irregular central necrosis in the right peritrigonal region. B, Base image from the perfusion CT study showing the tumor in the right peritrigonal region. C, Perfusion CT PS maps (C) showing very high permeability (PS = 5.14 mL/100 g per minute) along the enhancing nodular margins of the tumor and CBV maps (D) showing high blood volume (CBV = 3.49 mL/100 g) within the enhancing periphery of the tumor.
- Fig 4.
A and B, Postcontrast T1-weighted (TR/TE, 650/13 ms) axial image (A) and base image from perfusion CT study (B) in a 46-year-old man with a heterogeneously enhancing mass lesion predominantly involving the right frontal lobe with extension across the genu of the corpus callosum. C and D, Perfusion CT PS (C) and CBV (D) maps showing high permeability (PS = 2.04 mL/100 g per minute) and tumor blood volume (CBV = 2.21 mL/100 g). Histopathology revealed a grade III anaplastic astrocytoma.
- Fig 5.
A and B, Postcontrast T1-weighted (TR/TE, 3103/6.35 ms) image (A) and base image from perfusion CT study (B) in a 31-year-old man who presented with memory impairment and speech problems showing a nonenhancing mass in the left temporal lobe with minimal mass effect and perilesional edema. C and D, PS (C) and CBV (D) maps showing low permeability (PSA = 0.61 mL/100 g per minute) and low blood volume (CBV = 0.92 mL/100 g) within the mass. Histopathology revealed grade III anaplastic astrocytoma.
Tables
Group (No. of patients) PS (mL/100 g/min) Mean (SD) CBV (mL/100 g) Mean (SD) CBF (mL/100 g/min) Mean (SD) MTT (s) Mean (SD) Low grade (8) 0.52 (0.15) 0.95 (0.22) 27.0 (8.3) 4.24 (1.42) High grade (24) 2.37 (1.40) 2.79 (1.20) 82.0 (73.7) 4.67 (1.37) P value <.001 <.001 .0024 .564 C-statistic 0.927 0.930 0.849 0.573 ROC indicates receiver operating characteristic; PS, permeability surface-area product; CBV, cerebral blood volume; CBF, cerebral blood flow; MTT, mean transit time.
Group (No. of patients) PS (mL/100 g/min) Mean (SD) CBV (mL/100 g) Mean (SD) CBF (mL/100 g/min) Mean (SD) MTT (s) Mean (SD) WHO grade III (6) 1.04 (0.73) 1.82 (1.41) 38.9 (19.3) 4.60 (1.62) WHO grade IV (18) 2.81 (1.28) 3.12 (0.97) 96.3 (79.8) 4.69 (1.32) P value <.001 .039 .014 .922 C-statistic 0.926 0.787 0.833 0.509 ROC indicates receiver operating characteristic; PS, permeability surface-area product; CBV, cerebral blood volume; CBF, cerebral blood flow; MIT, mean transit time.
- Table 3:
Perfusion parameters and P values for nonenhancing versus enhancing grade III, nonenhancing grade III versus low grade, and enhancing grade III versus grade IV gliomas
PS (mL/100 g/min) Mean (SD) CBV (mL/100 g) Mean (SD) CBF (mL/100 g/min) Mean (SD) MTT (s) Mean (SD) Low grade (8) 0.52 (0.15) 0.95 (0.22) 27.0 (8.3) 4.24 (1.42) Nonenhancing grade III (3) 0.46 (0.13) 0.88 (0.16) 26.1 (3.4) 3.23 (0.64) Enhancing grade III (3) 1.61 (0.57) 2.77 (1.52) 51.7 (20.8) 5.96 (0.75) WHO grade IV (18) 2.81 (1.28) 3.12 (0.97) 96.3 (79.8) 4.69 (1.32) P values for nonenhancing vs. enhancing grade III .011 .029 .055 .012 P values for low grade vs. nonenhancing grade III .623 .699 .971 .330 P values for enhancing grade III vs. grade IV .052 .438 .322 .128 PS indicates permeability surface-area product; CBV, cerebral blood volume; CBF, cerebral blood flow; MTT, mean transit time.
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