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Research ArticleBrain

CT Perfusion Quantification of Small-Vessel Ischemic Severity

T.J. Huynh, B. Murphy, J.A. Pettersen, H. Tu, D.J. Sahlas, L. Zhang, S.P. Symons, S. Black, T.-Y. Lee and R.I. Aviv
American Journal of Neuroradiology November 2008, 29 (10) 1831-1836; DOI: https://doi.org/10.3174/ajnr.A1238
T.J. Huynh
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B. Murphy
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J.A. Pettersen
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H. Tu
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D.J. Sahlas
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L. Zhang
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S.P. Symons
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S. Black
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T.-Y. Lee
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R.I. Aviv
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References

  1. ↵
    Breteler MM, van Swieten JC, Bots ML, et al. Cerebral white matter lesions, vascular risk factors, and cognitive function in a population-based study: the Rotterdam Study. Neurology 1994;44:1246–52
    Abstract/FREE Full Text
  2. ↵
    Inzitari D, Mascalchi M, Giordano GP, et al. Histopathological correlates of leuko-araiosis in patients with ischemic stroke. Eur Neurol 1989;29 (suppl 2):23–26
    PubMedWeb of Science
  3. Scarpelli M, Salvolini U, Diamanti L, et al. MRI and pathological examination of post-mortem brains: the problem of white matter high signal areas. Neuroradiology 1994;36:393–98
    CrossRefPubMed
  4. ↵
    Janota I, Mirsen TR, Hachinski VC, et al. Neuropathologic correlates of leuko-araiosis. Arch Neurol 1989;46:1124–28
    CrossRefPubMedWeb of Science
  5. ↵
    Fernando MS, Simpson JE, Matthews F, et al, for the MRC Cognitive Function and Ageing Neuropathology Study Group. White matter lesions in an unselected cohort of the elderly: molecular pathology suggests origin from chronic hypoperfusion injury. Stroke 2006;37:1391–98
    Abstract/FREE Full Text
  6. Murray AD, Staff RT, Shenkin SD, et al. Brain white matter hyperintensities: relative importance of vascular risk factors in nondemented elderly people. Radiology 2005;237:251–57. Epub 2005 Aug 26
    CrossRefPubMedWeb of Science
  7. ↵
    Pantoni L, Garcia JH. The significance of cerebral white matter abnormalities 100 years after Binswanger's report: a review. Stroke 1995;26:1293–301
    Abstract/FREE Full Text
  8. ↵
    Fazekas F, Kleinert R, Offenbacher H, et al. Pathologic correlates of incidental MRI white matter signal hyperintensities. Neurology 1993;43:1683–89
    Abstract/FREE Full Text
  9. ↵
    Tomimoto H, Akiguchi I, Suenaga T, et al. Alterations of the blood-brain barrier and glial cells in white-matter lesions in cerebrovascular and Alzheimer's disease patients. Stroke 1996;27:2069–74
    Abstract/FREE Full Text
  10. ↵
    Hachinski V, Iadecola C, Petersen RC, et al. National Institute of Neurological Disorders and Stroke-Canadian Stroke Network vascular cognitive impairment harmonization standards. Stroke 2006;37:2220–41. Epub 2006 Aug 17
    Abstract/FREE Full Text
  11. ↵
    Miyazawa N, Satoh T, Hashizume K, et al. Xenon contrast CT-CBF measurements in high-intensity foci on T2-weighted MR images in centrum semiovale of asymptomatic individuals. Stroke 1997;28:984–87
    Abstract/FREE Full Text
  12. ↵
    Hatazawa J, Shimosegawa E, Satoh T, et al. Subcortical hypoperfusion associated with asymptomatic white matter lesions on magnetic resonance imaging. Stroke 1997;28:1944–47
    Abstract/FREE Full Text
  13. ↵
    O'Sullivan M, Lythgoe DJ, Pereira AC, et al. Patterns of cerebral blood flow reduction in patients with ischemic leukoaraiosis. Neurology 2002;59:321–26
    Abstract/FREE Full Text
  14. ↵
    Marstrand JR, Garde E, Rostrup E, et al. Cerebral perfusion and cerebrovascular reactivity are reduced in white matter hyperintensities. Stroke 2002;33:972–76
    Abstract/FREE Full Text
  15. ↵
    De Cristofaro MT, Mascalchi M, Pupi A, et al. Subcortical arteriosclerotic encephalopathy: single photon emission computed tomography-magnetic resonance imaging correlation. Am J Physiol Imaging 1990;5:68–74
    PubMed
  16. ↵
    Wardlaw JM, Sandercock PAG, Dennis MS, et al. Is breakdown of the blood-brain barrier responsible for lacunar stroke, leukoaraiosis, and dementia? Stroke 2003;34:806–12
    Abstract/FREE Full Text
  17. ↵
    Starr JM, Wardlaw J, Ferguson K, et al. Increased blood-brain barrier permeability in type II diabetes demonstrated by gadolinium magnetic resonance imaging. J Neurol Neurosurg Psychiatry 2003;74:70–76
    Abstract/FREE Full Text
  18. ↵
    Kemper TL, Blatt GJ, Killiany RJ, et al. Neuropathology of progressive cognitive decline in chronically hypertensive rhesus monkeys. Acta Neuropathol 2001;101:145–53
    PubMedWeb of Science
  19. ↵
    Aviv RI, Hopyan B, Mallia G, et al. Computer Tomographic Perfusion Derived Permeability (permeability surface) Predicts Hemorrhagic Transformation: Proceedings of the International Stroke Conference, New Orleans, La, 20–22 February 2008. New Orleans, La: American Heart Association;2008
  20. ↵
    Wintermark M, Thiran J-P, Maeder P, et al. Simultaneous measurement of regional cerebral blood flow by perfusion CT, and stable xenon CT: a validation study. AJNR Am J Neuroradiol 2001;22:905–14
    Abstract/FREE Full Text
  21. ↵
    Kudo K, Terae S, Katoh C, et al. Quantitative cerebral blood flow measurement with dynamic perfusion CT using the vascular-pixel elimination method: comparison with H2(15)O positron emission tomography. AJNR Am J Neuroradiol 2003;24:419–26
    Abstract/FREE Full Text
  22. ↵
    Murphy BD, Fox AJ, Lee DH, et al. White matter thresholds for ischemic penumbra and infarct core in patients with acute stroke: CT perfusion study. Radiology 2008;247:818–25. Epub 2008 Apr 18
    CrossRefPubMedWeb of Science
  23. ↵
    Murphy BD, Fox AJ, Lee DH, et al. Identification of penumbra and infarct in acute ischemic stroke using computed tomography perfusion-derived blood flow and blood volume measurements. Stroke 2006;37:1771–77
    Abstract/FREE Full Text
  24. ↵
    Wahlund LO, Barkhof F, Fazekas F, et al. A new rating scale for age-related white matter changes applicable to MRI and CT. Stroke 2001;32:1318–22
    Abstract/FREE Full Text
  25. ↵
    Cohnen M, Wittsack H-J, Assadi S, et al. Radiation exposure of patients in comprehensive computed tomography of the head in acute stroke. AJNR Am J Neuroradiol 2006;27:1741–45
    Abstract/FREE Full Text
  26. ↵
    Brenner DJ, Hall EJ. Computed tomography: an increasing source of radiation exposure. N Engl J Med 2007;357:2277–84
    CrossRefPubMedWeb of Science
  27. ↵
    O'Sullivan M, Rich PM, Barrick TR, et al. Frequency of subclinical lacunar infarcts in ischemic leukoaraiosis and cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy. AJNR Am J Neuroradiol 2003;24:1348–54
    Abstract/FREE Full Text
  28. ↵
    Markus HS, Lythgoe DJ, Ostegaard L, et al. Reduced cerebral blood flow in white matter in ischaemic leukoaraiosis demonstrated using quantitative exogenous contrast-based perfusion MRI. J Neurol Neurosurg Psychiatry 2000;69:48–53
    Abstract/FREE Full Text
  29. ↵
    Powers WJ. Cerebral hemodynamics in ischemic cerebrovascular disease. Ann Neurol 1991;29:231–40
    CrossRefPubMedWeb of Science
  30. ↵
    Bakker SL, de Leeuw FE, de Groot JC, et al. Cerebral vasomotor reactivity and cerebral white matter lesions in the elderly. Neurology 1999;52:578–83
    Abstract/FREE Full Text
  31. ↵
    Hassan A, Hunt BJ, O'Sullivan M, et al. Markers of endothelial dysfunction in lacunar infarction and ischaemic leukoaraiosis. Brain 2003;126:424–32
    Abstract/FREE Full Text
  32. ↵
    Roberts HC, Roberts TPL, Lee T-Y, et al. Dynamic, contrast-enhanced CT of human brain tumors: quantitative assessment of blood volume, blood flow, and microvascular permeability—report of two cases. AJNR Am J Neuroradiol 2002;23:828–32
    Abstract/FREE Full Text
  33. ↵
    Lin K, Kazmi KS, Law M, et al. Measuring elevated microvascular permeability and predicting hemorrhagic transformation in acute ischemic stroke using first-pass dynamic perfusion CT imaging. AJNR Am J Neuroradiol 2007;28:1292–98
    Abstract/FREE Full Text
  34. ↵
    Zimny A, Sasiadek M, Leszek J, et al. Does perfusion CT enable differentiating Alzheimer's disease from vascular dementia and mixed dementia? A preliminary report. J Neurol Sci 2007;257:114–20
    CrossRefPubMed
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American Journal of Neuroradiology: 29 (10)
American Journal of Neuroradiology
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Cite this article
T.J. Huynh, B. Murphy, J.A. Pettersen, H. Tu, D.J. Sahlas, L. Zhang, S.P. Symons, S. Black, T.-Y. Lee, R.I. Aviv
CT Perfusion Quantification of Small-Vessel Ischemic Severity
American Journal of Neuroradiology Nov 2008, 29 (10) 1831-1836; DOI: 10.3174/ajnr.A1238

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CT Perfusion Quantification of Small-Vessel Ischemic Severity
T.J. Huynh, B. Murphy, J.A. Pettersen, H. Tu, D.J. Sahlas, L. Zhang, S.P. Symons, S. Black, T.-Y. Lee, R.I. Aviv
American Journal of Neuroradiology Nov 2008, 29 (10) 1831-1836; DOI: 10.3174/ajnr.A1238
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  • Interaction of age with the ischaemic penumbra, leptomeningeal collateral circulation and haemodynamic variables in acute stroke: a pilot study
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