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AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticleBRAIN

Mineralization of the Deep Gray Matter with Age: A Retrospective Review with Susceptibility-Weighted MR Imaging

S.L. Harder, K.M. Hopp, H. Ward, H. Neglio, J. Gitlin and D. Kido
American Journal of Neuroradiology January 2008, 29 (1) 176-183; DOI: https://doi.org/10.3174/ajnr.A0770
S.L. Harder
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K.M. Hopp
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H. Ward
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H. Neglio
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J. Gitlin
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D. Kido
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Article Figures & Data

Figures

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  • Fig 1.
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    Fig 1.

    Axial SWI image demonstrating a region of interest drawn around the putamen (arrow) and globus pallidus (arrowhead).

  • Fig 2.
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    Fig 2.

    A schematic drawing of the putamen (A) and corresponding axial SWI images (B) demonstrating the mSHIP scale (grades 0 to 4).

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    Fig 3.

    Axial SWI image through the globus pallidus demonstrates mineralization of the medial (arrow) and lateral (arrowhead) aspects of the nucleus.

  • Fig 4.
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    Fig 4.

    Axial SWI images through the right globus pallidus. Images A to E demonstrate increasing numbers of waves with the final image (E), showing conglomerate waves.

  • Fig 5.
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    Fig 5.

    Axial SWI image through the level of the midbrain demonstrating the red nucleus (arrowhead), substantia nigra (thick arrow), and fascicula nigrale (thin arrow).

  • Fig 6.
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    Fig 6.

    Putaminal intensity per area decreases with age. The line represents Equation 1, with the parameter for the putamen as given in Table 4.

  • Fig 7.
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    Fig 7.

    Intensity per area of the globus pallidus decreases with age. The line represents Equation 1, with the parameter for the globus pallidus as given in Table 4.

  • Fig 8.
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    Fig 8.

    Putaminal grade is shown to increase with age.

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    Fig 9.

    Globus pallidus “waves” increase with age.

Tables

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    Table 1:

    Subject count per age decade

    DecadeNo. of Subjects
    1st19
    2nd22
    3rd13
    4th10
    5th17
    6th18
    7th11
    8th13
    9th11
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    Table 2:

    Modified scale of hypointensity in the putamen (mSHIP)

    GradeDefinition
    0No mineralization
    1Mineralization of the posterolateral aspect of the putamen
    2Mineralization of the lateral half of the putamen
    3Mineralization of the lateral half and the posteromedial aspect of the putamen
    4Mineralization of the entire putamen
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    Table 3:

    Globus pallidus wave score

    ScoreDefinition
    0No waves
    11 wave
    22 waves
    33 waves
    44 waves
    55 waves or confluent waves
    • View popup
    Table 4:

    Fit of intensity vs age data to inverse iron concentration curves*

    y0AbCorrelation, r
    Globus pallidus0.0200.0180.090.8
    Putamen0.0230.0110.090.5
    Substantia nigra0.0120.00650.040.5
    • * See Equation 1.

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American Journal of Neuroradiology: 29 (1)
American Journal of Neuroradiology
Vol. 29, Issue 1
January 2008
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Cite this article
S.L. Harder, K.M. Hopp, H. Ward, H. Neglio, J. Gitlin, D. Kido
Mineralization of the Deep Gray Matter with Age: A Retrospective Review with Susceptibility-Weighted MR Imaging
American Journal of Neuroradiology Jan 2008, 29 (1) 176-183; DOI: 10.3174/ajnr.A0770

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Mineralization of the Deep Gray Matter with Age: A Retrospective Review with Susceptibility-Weighted MR Imaging
S.L. Harder, K.M. Hopp, H. Ward, H. Neglio, J. Gitlin, D. Kido
American Journal of Neuroradiology Jan 2008, 29 (1) 176-183; DOI: 10.3174/ajnr.A0770
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