Article Figures & Data
Figures
- Fig 1.
A, In MTR histograms, the normalized whole brain peak for patients with HIV is lower and shifted to the left, demonstrating significantly reduced MTR value compared with that of control subjects. AU indicates arbitrary unit; asterisk, P < .05. B, Whole brain mean MTR and peak site for HIV and control subjects. Asterisk indicates P < .05; double asterisks, P < .01.
- Fig 2.
A, ROIs. From left to right, MT without saturation, MT with saturation, and MTR color maps. B, Group comparisons of the HIV and controls for the studied ROIs. Splen indicates splenium; CSEM, centrum semiovale; Put, putamen; Caud, caudate; Thal, thalamus; asterisk, P < .05; double asterisks, P < .01.
- Fig 3.
Scatterplots of significant correlations between MTR measurements and cognitive status measures, including the MSK ordinal-scale dementia rating (A–C) and continuous cognitive function variables (D–F).
Tables
Correlations of MTR measurements and cognitive status measures
Whole Brain MTR Localized MTR Mmtr NPH PSite Genu Splen FWM CSEM Put Caud Thal MSK −0.64* −0.57* −0.36 −0.61* −0.53* −0.46* −0.38 −0.51* −0.39 −0.51* Working memory 0.03 −0.51 0.32 0.11 0.29 0.25 0.31 0.06 0.08 0.09 Verbal memory −0.14 0.51 −0.24 −0.23 −0.01 −0.28 −0.32 −0.02 −0.33 −0.05 Visual memory 0.47 0.18 0.25 0.48* 0.48* 0.42 0.46* 0.10 0.30 0.30 Visuoconstruction 0.43 −0.05 0.43 0.49* 0.20 0.56* 0.54* 0.28 0.41 0.37 Psychomotor 0.11 0.27 0.07 0.24 0.19 0.04 −0.12 0.15 −0.25 0.23 Motor speed 0.40 0.46 0.11 0.24 0.54* 0.24 0.11 0.26 0.05 0.42 Executive function −0.26 0.14 −0.25 −0.37 −0.14 −0.26 −0.22 −0.36 −0.24 −0.16 Note:—Mmtr = mean MTR; NPH, normalized peak height; Psite, peak site; Splen, splenium; FWM, frontal white matter; CSEM, centrum semiovale; Put, putamen; Caud, caudate; Tha; thalamus.
* Significant using FDR-adjusted P value. Spearman correlation coefficients for MSK; all others, Pearson correlation coefficients.
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