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Research ArticleBRAIN

Measuring Brain Volume by MR Imaging: Impact of Measurement Precision and Natural Variation on Sample Size Requirements

R.G. Steen, R.M. Hamer and J.A. Lieberman
American Journal of Neuroradiology June 2007, 28 (6) 1119-1125; DOI: https://doi.org/10.3174/ajnr.A0537
R.G. Steen
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R.M. Hamer
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J.A. Lieberman
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References

  1. ↵
    Shenton ME, Dickey CC, Frumin M, et al. A review of MRI findings in schizophrenia. Schizophr Res 2001;49:1–52
    PubMedWeb of Science
  2. ↵
    Steen, RG, Mull C, McClure R, et al. Brain volume in first-episode schizophrenia: systematic review and meta-analysis of magnetic resonance imaging studies. Br J Psychiatry 2006;188:510–18
    Abstract/FREE Full Text
  3. ↵
    Styner M, Charles HC, Park J, Gerig G. Multisite validation of image analysis methods: assessing intra- and intersite variability. In: Sonka M, Fitzpatrick JM, eds. Medical Imaging 2002: Image Processing. Proc. SPIE Vol. 4684;2002 :278–86
  4. ↵
    Lieberman JA, Tollefson G, Tohen M. Comparative efficacy and safety of atypical and conventional antipsychotic drugs in first-episode psychosis: a randomized, double-blind trial of olanzapine versus haloperidol. Am J Psychiatry 2003;160:1396–404
    CrossRefPubMedWeb of Science
  5. Perkins DO, Lieberman JA, Gu H, et al. Predictors of antipsychotic treatment response in patients with first-episode schizophrenia, schizoaffective, and schizophreniform disorders. Br J Psychiatry 2004;185:18–24
    Abstract/FREE Full Text
  6. ↵
    Lieberman JA, Tollefson GD, Charles C, et al. Antipsychotic drug effects on brain morphology in first-episode patients. Arch Gen Psychiatry 2005;62:361–70
    CrossRefPubMedWeb of Science
  7. ↵
    Van Leemput K, Maes F, Vandermeulen D, et al. Automated model-based tissue classification of MR images of the brain. IEEE Trans Med Imaging 1999;18:897–908
    CrossRefPubMedWeb of Science
  8. ↵
    Benedetti B, Charil A, Rovaris M, et al. Influence of aging on brain gray and white matter changes assessed by conventional, MT, and DT MRI. Neurology 2006;66:535–39
    Abstract/FREE Full Text
  9. ↵
    Brickman AM, Habeck C, Zarahn E, et al. Structural MRI covariance patterns associated with normal aging and neuropsychological functioning. Neurobiol Aging 2007;28:284–95. Epub 2006 Feb 15
    CrossRefPubMedWeb of Science
  10. ↵
    Giedd JN, Rumsey JM, Castellanos FX, et al. A quantitative MRI study of the corpus callosum in children and adolescents. Brain Res Dev Brain Res 1996;91:274–80
    CrossRefPubMed
  11. ↵
    Rajapakse JC, Giedd JN, DeCarli C, et al. A technique for single-channel MR brain tissue segmentation: application to a pediatric sample. Mag Reson Imag 1996;14:1053–65
    CrossRef
  12. ↵
    Andreasen NC, Flaum M, Swayze VW 2nd, et al. Intelligence and brain structure in normal individuals. Am J Psychiatry 1993;150:130–34
    PubMedWeb of Science
  13. ↵
    Harrison PJ, Freemantle N, Geddes JR, et al. Meta-analysis of brain weight in schizophrenia. Schizophr Res 2003;64:25–34
    CrossRefPubMedWeb of Science
  14. ↵
    Whitwell JL, Crum WR. Normalization of cerebral volumes by use of intracranial volume: implications for longitudinal quantitative MR imaging. AJNR Am J Neuroradiol 2001;22:1483–89
    Abstract/FREE Full Text
  15. ↵
    Testa C, Laakso MP, Sabattoli F, et al. A comparison between the accuracy of voxel-based morphometry and hippocampal volumetry in Alzheimer's disease. J Magn Reson Imaging 2004;19:274–82
    CrossRefPubMedWeb of Science
  16. ↵
    Saver JL. Time is brain-quantified. Stroke 2006;37:263–66
    Abstract/FREE Full Text
  17. ↵
    Duning T, Kloska S, Steinstrater O, et al. Dehydration confounds the assessment of brain atrophy. Neurology 2005;64:548–50
    Abstract/FREE Full Text
  18. ↵
    Cho K. Chronic “jet lag” produces temporal lobe atrophy and spatial cognitive deficits. Nat Neurosci 2001;4:567–68
    CrossRefPubMedWeb of Science
  19. ↵
    Sokol DK, Demyer WE, Edwards-Brown M, et al. From swelling to sclerosis: acute change in mesial hippocampus after prolonged febrile seizures. Seizure 2003;12:237–40
    CrossRefPubMed
  20. ↵
    Frank GK, Bailer UF, Henry S, et al. Neuroimaging studies in eating disorders. CNS Spectr 2004;9:539–48
    PubMed
  21. ↵
    Moore GJ, Bebchuk JM, Wilds IB, et al. Lithium-induced increase in human brain grey matter. Lancet 2000;356:1241–42
    CrossRefPubMedWeb of Science
  22. ↵
    Hardmeier M, Wagenpfeil S, Freitag P, et al. Atrophy is detectable within a 3-month period in untreated patients with active relapsing-remitting multiple sclerosis. Arch Neurol 2003;60:1736–39
    CrossRefPubMedWeb of Science
  23. ↵
    Hoogervorst EL, Polman CH, Barkhof F, et al. Cerebral volume changes in multiple sclerosis patients treated with high-dose intravenous methylprednisolone. Mult Scler 2002;8:415–19
    Abstract/FREE Full Text
  24. ↵
    Gilbert AR, Moore GJ, Keshavan MS, et al. Decrease in thalamic volumes of pediatric patients with obsessive-compulsive disorder who are taking paroxetine. Arch Gen Psychiatry 2000;57:449–56
    CrossRefPubMedWeb of Science
  25. ↵
    Denton ER, Holden M, Christ E, et al. The identification of cerebral volume changes in treated growth-hormone deficient adults using serial 3D MR image processing. J Comput Assist Tomogr 2000;24:139–45
    CrossRefPubMedWeb of Science
  26. ↵
    Walters RJ, Fox NC, Crum WR, et al. Haemodialysis and cerebral oedema. Nephron 2001;87:143–47
    CrossRefPubMedWeb of Science
  27. ↵
    Garver DL, Nair TR, Christensen JD, et al. Brain and ventricle instability during psychotic episodes of the schizophrenias. Schizophr Res 2000;44:11–23
    CrossRefPubMedWeb of Science
  28. ↵
    Pfefferbaum A, Sullivan EV, Mathalon DH, et al. Longitudinal changes in magnetic resonance imaging brain volumes in abstinent and relapsed alcoholics. Alcohol Clin Exp Res 1995;19:1177–91
    CrossRefPubMedWeb of Science
  29. ↵
    Pfefferbaum A, Rosenbloom MJ, Serventi KL, et al. Brain volumes, RBC status, and hepatic function in alcoholics after 1 and 4 weeks of sobriety: predictors of outcome. Am J Psychiatry 2004;161:1190–96
    CrossRefPubMedWeb of Science
  30. ↵
    Agartz I, Brag S, et al. MR volumetry during acute alcohol withdrawal and abstinence: a descriptive study. Alcohol Alcohol 2003;38:71–78
    Abstract/FREE Full Text
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American Journal of Neuroradiology: 28 (6)
American Journal of Neuroradiology
Vol. 28, Issue 6
June 2007
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Cite this article
R.G. Steen, R.M. Hamer, J.A. Lieberman
Measuring Brain Volume by MR Imaging: Impact of Measurement Precision and Natural Variation on Sample Size Requirements
American Journal of Neuroradiology Jun 2007, 28 (6) 1119-1125; DOI: 10.3174/ajnr.A0537

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Measuring Brain Volume by MR Imaging: Impact of Measurement Precision and Natural Variation on Sample Size Requirements
R.G. Steen, R.M. Hamer, J.A. Lieberman
American Journal of Neuroradiology Jun 2007, 28 (6) 1119-1125; DOI: 10.3174/ajnr.A0537
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