Article Figures & Data
Figures
- Fig 1.
Illustration of representative regions of interests positioned on T2-weighted echo-planar images (b = 0 s/mm2) in the NAWM of the frontal (A), temporal (B), parietal (C), and occipital lobes (D).
- Fig 2.
Correlation of diffusion measurements with cognitive tests in all subjects. Poorer cognitive function is reflected by lower WLDR scores, higher TMT-B scores, and lower CP scores.
Tables
AD (n = 6) MCI (n = 11) NC (n = 8) Age (years) 78 (65–88) 76 (61–87) 73.5 (62–78) Sex (female/male) 4/2 5/6 5/3 Education (years) 13 (10–18) 16 (11–18) 15.5 (11–18) Mini-Mental State Exam 23 (20–26)c 27 (24–30)c 30 (28–30) Verbal Fluency 9.5 (8–12)cd 17 (11–20) 21.5 (14–32) Boston Naming 13 (7–13) 13 (8–15) 14.5 (13–15) CP 7.5 (6–11) 11 (4–11) 11 (10–11) Word List Memory Total 11 (8–21)c 18 (9–21) 23.5 (15–28) WLDR 2.5 (0–3)c 4 (0–8)c 8 (7–10) Word List Recognition 18 (16–19) 19 (17–20) 20 (19–20) Constructional Praxis Recall 1 (0–8) 6 (2–11) 11 (9–14) TMT-A 69.5 (41–254)c 40 (22–66) 26.5 (16–54) TMT-B 184.5 (138–300)c 111 (53–203) 60.5 (38–95) Note:—NC indicates control subjects; WLDR, Word List Delayed Recall; CP, Constructional Praxis; TMT, Trail-Making Test.
a TMT-A and TMT-B are in units of seconds. All other neuropsychological units are the number of correct responses.
b Median (ranges) except sex.
c Statistically significant versus NC.
d Statistically significant versus MCI.
- Table 2:
Diffusion tensor measurements (median [ranges]) of selected NAWM regions among AD, MCI, and NC subjectsa
AD (n = 6) MCI (n = 11) NC (n = 8) Frontal FA 0.25 (0.22–0.29)b 0.29 (0.25–0.38) 0.33 (0.27–0.39) Frontal DA 1.13 (0.97–1.18) 1.06 (0.95–1.13) 1.07 (1.03–1.13) Frontal DR 0.78 (0.67–0.85)bc 0.69 (0.60–0.75) 0.64 (0.59–0.74) Temporal FA 0.38 (0.34–0.43)bc 0.43 (0.40–0.48)b 0.50 (0.45–0.58) Temporal DA 1.18 (1.16–1.24)b 1.20 (1.15–1.36)b 1.29 (1.27–1.36) Temporal DR 0.66 (0.61–0.71)b 0.61 (0.55–0.70) 0.57 (0.48–0.62) Parietal FA 0.38 (0.35–0.43)b 0.40 (0.33–0.43)b 0.46 (0.44–0.48) Parietal DA 1.14 (1.07–1.25) 1.12 (1.05–1.18) 1.15 (1.12–1.23) Parietal DR 0.63 (0.61–0.66)b 0.60 (0.57–0.64)b 0.57 (0.54–0.59) Occipital FA 0.42 (0.36–0.43) 0.45 (0.39–0.56) 0.45 (0.33–0.50) Occipital DA 1.19 (1.15–1.24) 1.21 (1.06–1.42) 1.19 (1.09–1.38) Occipital DR 0.62 (0.60–0.66) 0.60 (0.52–0.68) 0.59 (0.50–0.72) Note:—NC indicates control subjects.
a DA and DR are in units of 10−3 mm2/s.
b Statistically significant versus NC.
c Statistically significant versus MCI.
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