Skip to main content
Advertisement

Main menu

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home

User menu

  • Alerts
  • Log in

Search

  • Advanced search
American Journal of Neuroradiology
American Journal of Neuroradiology

American Journal of Neuroradiology

ASHNR American Society of Functional Neuroradiology ASHNR American Society of Pediatric Neuroradiology ASSR
  • Alerts
  • Log in

Advanced Search

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home
  • Follow AJNR on Twitter
  • Visit AJNR on Facebook
  • Follow AJNR on Instagram
  • Join AJNR on LinkedIn
  • RSS Feeds

AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

OtherReview articles

Whole-Brain N-Acetylaspartate as a Surrogate Marker of Neuronal Damage in Diffuse Neurologic Disorders

D.J. Rigotti, M. Inglese and O. Gonen
American Journal of Neuroradiology November 2007, 28 (10) 1843-1849; DOI: https://doi.org/10.3174/ajnr.A0774
D.J. Rigotti
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
M. Inglese
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
O. Gonen
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • Responses
  • References
  • PDF
Loading

References

  1. ↵
    McFarland H. The lesion in multiple sclerosis: clinical, pathological, and magnetic resonance imaging considerations. J Neurol Neurosurg Psychiatry 1998;64S1:S26–S30
  2. Ferguson B, Matyszak MK, Esiri MM, et al. Axonal damage in acute multiple sclerosis lesions. Brain 1997;120:393–99
    Abstract/FREE Full Text
  3. ↵
    Bitsch A, Bruhn H, Vougioukas V, et al. Inflammatory CNS demyelination: histopathologic correlation with in vivo quantitative proton MR spectroscopy. AJNR Am J Neuroradiol 1999;20:1619–27
    Abstract/FREE Full Text
  4. ↵
    Miller BL. A review of chemical issues in 1H NMR spectroscopy: N-acetyl-L-aspartate, creatine and choline. NMR Biomed 1991;4:47–52
    CrossRefPubMedWeb of Science
  5. ↵
    Lin A, Ross BD, Harris K, et al. Efficacy of proton magnetic resonance spectroscopy in neurological diagnosis and neurotherapeutic decision making. NeuroRx 12005;2:197–214
  6. ↵
    Tallan HH, Moore S, Stein WH. N-acetyl-L-aspartic acid in brain. J Biol Chem 1956;219:257–64
    FREE Full Text
  7. ↵
    Simmons ML, Frondoza CG, Coyle JT. Immunocytochemical localization of N-acetyl-aspartate with monoclonal antibodies. Neuroscience 1991;45:37–45
    CrossRefPubMedWeb of Science
  8. Jenkins BG, Klivenyi P, Kustermann E, et al. Nonlinear decrease over time in N-acetyl aspartate levels in the absence of neuronal loss and increases in glutamine and glucose in transgenic Huntington's disease mice. J Neurochem 2000;74:2108–19
    CrossRefPubMedWeb of Science
  9. ↵
    Moffett JR, Namboodiri MA, Cangro CB, et al. Immunohistochemical localization of N-acetylaspartate in rat brain. Neuroreport 1991;2:131–34
    PubMedWeb of Science
  10. ↵
    Baslow MH, Resnik TR. Canavan disease: analysis of the nature of the metabolic lesions responsible for development of the observed clinical symptoms. J Mol Neurosci 1997;9:109–25
    CrossRefPubMedWeb of Science
  11. ↵
    Danielsen EA, Ross B. Magnetic Resonance Spectroscopy Diagnosis of Neurological Diseases. New York: Marcel Dekker;1999 .
  12. ↵
    Ross BD, Bluml S. Magnetic resonances of the human brain. Anat Rec 2001;265:54–84
    CrossRefPubMed
  13. ↵
    Bjartmar C, Battistuta J, Terada N, et al. N-acetylaspartate is an axon-specific marker of mature white matter in vivo: a biochemical and immunohistochemical study on the rat optic nerve. Ann Neurol 2002;51:51–58
    CrossRefPubMedWeb of Science
  14. ↵
    Bjartmar C, Kidd G, Mork S, et al. Neurological disability correlates with spinal cord axonal loss and reduced N-acetyl aspartate in chronic multiple sclerosis patients. Ann Neurol 2000;48:893–901
    CrossRefPubMedWeb of Science
  15. ↵
    Goldstein FB. Biosynthesis of N-acetyl-L-aspartic acid. Biochim Biophys Acta 1959;33:583–84
    PubMed
  16. ↵
    Baslow MH, Guilfoyle DN. Effect of N-acetylaspartic acid on the diffusion coefficient of water: a proton magnetic resonance phantom method for measurement of osmolyte-obligated water. Anal Biochem 2002;311:133–38
    CrossRefPubMed
  17. ↵
    Chakraborty G, Mekala P, Yahya D, et al. Intraneuronal N-acetylaspartate supplies acetyl groups for myelin lipid synthesis: evidence for myelin-associated aspartoacylase. J Neurochem 2001;78:736–45
    CrossRefPubMedWeb of Science
  18. ↵
    Madhavarao CN, Chinopoulos C, Chandrasekaran K, et al. Characterization of the N-acetylaspartate biosynthetic enzyme from rat brain. J Neurochem 2003;86:824–35
    CrossRefPubMedWeb of Science
  19. ↵
    Yan HD, Ishihara K, Serikawa T, et al. Activation by N-acetyl-L-aspartate of acutely dissociated hippocampal neurons in rats via metabotropic glutamate receptors. Epilepsia 2003;44:1153–59
    CrossRefPubMed
  20. ↵
    Kreis R, Ernst T, Ross BD. Absolute quantitation of water and metabolites in the human brain. II. metabolite concentrations. J Magn Reson Series B 1993;102:9–19
    CrossRefWeb of Science
  21. Birken DL, Oldendorf WH. N-acetyl-L-aspartic acid: a literature review of a compound prominent in 1H-NMR spectroscopic studies of brain. Neurosci Biobehav Rev 1989;13:23–31
    CrossRefPubMedWeb of Science
  22. Arnold DL, de Stefano N, Matthews PM, et al. N-acetylaspartate: usefulness as an indicator of viable neuronal tissue. Ann Neurol 2001;50:823–25
    PubMedWeb of Science
  23. ↵
    Baslow MH. Functions of N-acetyl-L-aspartate and N-acetyl-L-aspartylglutamate in the vertebrate brain: role in glial cell-specific signaling. J Neurochem 2000;75:453–59
    CrossRefPubMedWeb of Science
  24. ↵
    Brooks WM, Friedman SD, Stidley CA. Reproducibility of 1H-MRS in vivo. Magn Reson Med 1999;41:193–97
    CrossRefPubMedWeb of Science
  25. Marshall I, Wardlaw J, Cannon J, et al. Reproducibility of metabolite peak areas in 1H MRS of brain. Magn Reson Imaging 1996;14:281–92
    CrossRefPubMedWeb of Science
  26. ↵
    Bokde AL, Teipel SJ, Zebuhr Y, et al. A new rapid landmark-based regional MRI segmentation method of the brain. J Neurol Sci 2002;194:35–40
    CrossRefPubMedWeb of Science
  27. ↵
    Inglese M, Ge Y, Filippi M, et al. Indirect evidence for early widespread gray matter involvement in relapsing-remitting multiple sclerosis. Neuroimage 2004;21:1825–29
    CrossRefPubMedWeb of Science
  28. ↵
    De Stefano N, Narayanan S, Francis SJ, et al. Diffuse axonal and tissue injury in patients with multiple sclerosis with low cerebral lesion load and no disability. Arch Neurol 2002;59:1565–71
    CrossRefPubMedWeb of Science
  29. ↵
    Zaaraoui W, Fleysher L, Fleysher R, et al. Human brain-structure resolved T(2) relaxation times of proton metabolites at 3 Tesla. Magn Reson Med 2007;57:983–89
    CrossRefPubMed
  30. ↵
    Gonen O, Viswanathan AK, Catalaa I, et al. Total brain N-acetylaspartate concentration in normal, age-grouped females: quantitation with non-echo proton NMR spectroscopy. Magn Reson Med 1998;40:684–89
    PubMedWeb of Science
  31. ↵
    Udupa JK, Odhner D, Samarasekera S. 3DVIEWNIX: an open, transportable, multdimensional, multimodality, multiparametric imaging software system. Proc SPIE 1994;2164:58–73
    CrossRef
  32. ↵
    De Santi S, de Leon MJ, Rusinek H, et al. Hippocampal formation glucose metabolism and volume losses in MCI and AD. Neurobiol Aging 2001;22:529–39
    CrossRefPubMedWeb of Science
  33. ↵
    Ashburner J, Hutton C, Frackowiak R, et al. Identifying global anatomical differences: deformation-based morphometry. Hum Brain Mapp 1998;6:348–57
    CrossRefPubMedWeb of Science
  34. ↵
    Smith SM, De Stefano N, Jenkinson M, et al. Normalized accurate measurement of longitudinal brain change. J Comput Assist Tomogr 2001;25:466–75
    CrossRefPubMedWeb of Science
  35. ↵
    Smith SM, Zhang Y, Jenkinson M, et al. Accurate, robust, and automated longitudinal and cross-sectional brain change analysis. Neuroimage 2002;17:479–89
    CrossRefPubMedWeb of Science
  36. ↵
    Smith SM, Rao A, De Stefano N, et al. Longitudinal and cross-sectional analysis of atrophy in Alzheimer's disease: cross-validation of BSI, SIENA and SIENAX. Neuroimage 2007;36:1200–06. Epub 2007 Apr 27
    CrossRefPubMedWeb of Science
  37. ↵
    Gonen O, Grossman RI. The accuracy of whole brain N-acetylaspartate quantification. Magn Reson Imaging 2000;18:1255–58
    CrossRefPubMedWeb of Science
  38. ↵
    Filippi M, Bozzali M, Rovaris M, et al. Evidence for widespread axonal damage at the earliest clinical stage of multiple sclerosis. Brain 2003;126:433–37
    Abstract/FREE Full Text
  39. ↵
    Benedetti B, Rigotti DJ, Liu S, et al. Reproducibility of the whole-brain N-acetylaspartate level across institutions, MR scanners, and field strengths. AJNR Am J Neuroradiol 2007;28:72–75
    Abstract/FREE Full Text
  40. ↵
    Rigotti DJ, Inglese M, Babb JS, et al. Serial whole-brain N-acetylaspartate concentration in healthy young adults. AJNR Am J Neuroradiol. 2007;28:1650–51
    Abstract/FREE Full Text
  41. ↵
    Falini A, Bozzali M, Magnani G, et al. A whole brain MR spectroscopy study from patients with Alzheimer's disease and mild cognitive impairment. Neuroimage 2005;26:1159–63
    CrossRefPubMed
  42. ↵
    Scahill RI, Frost C, Jenkins R, et al. A longitudinal study of brain volume changes in normal aging using serial registered magnetic resonance imaging. Arch Neurol 2003;60:989–94
    CrossRefPubMedWeb of Science
  43. ↵
    Compston A, Coles A. Multiple sclerosis. Lancet 2002;359:1221–31
    CrossRefPubMedWeb of Science
  44. ↵
    Sayao AL, Devonshire V, Tremlett H. Longitudinal follow-up of “benign” multiple sclerosis at 20 years. Neurology 2007;68:496–500
    Abstract/FREE Full Text
  45. ↵
    Montalban X. Primary progressive multiple sclerosis. Curr Opin Neurol 2005;18:261–66
    PubMedWeb of Science
  46. ↵
    Cree B. Emerging monoclonal antibody therapies for multiple sclerosis. Neurologist 2006;12:171–78
    CrossRefPubMedWeb of Science
  47. Hartung HP, Bar-Or A, Zoukos Y. What do we know about the mechanism of action of disease-modifying treatments in MS? J Neurol 2004;251 (suppl 5):v12–v29
    CrossRefPubMed
  48. ↵
    Fox EJ. Management of worsening multiple sclerosis with mitoxantrone: a review. Clin Ther 2006;28:461–74
    CrossRefPubMedWeb of Science
  49. ↵
    Miller DH, Thompson AJ, Filippi M. Magnetic resonance studies of abnormalities in the normal-appearing white matter and gray matter in multiple sclerosis. J Neurol 2003;250:1407–19
    CrossRefPubMedWeb of Science
  50. ↵
    Gonen O, Catalaa I, Babb JS, et al. Total brain N-acetylaspartate: a new measure of disease load in MS. Neurology 2000;54:15–19
    Abstract/FREE Full Text
  51. ↵
    Rovaris M, Gallo A, Falini A, et al. Axonal injury and overall tissue loss are not related in primary progressive multiple sclerosis. Arch Neurol 2005;62:898–902
    CrossRefPubMedWeb of Science
  52. ↵
    Ge Y, Gonen O, Inglese M, et al. Neuronal cell injury precedes brain atrophy in multiple sclerosis. Neurology 2004;62:624–27
    Abstract/FREE Full Text
  53. ↵
    Lumsden C. The clinical immunology of multiple sclerosis. In: BG Vinken PJ, ed. Handbook of Clinical Neurology. Vol.9 . North-Holland, Amsterdam: Elsevier;1970 :217–309
  54. ↵
    Gonen O, Moriarty DM, Li BS, et al. Relapsing-remitting multiple sclerosis and whole-brain N-acetylaspartate measurement: evidence for different clinical cohorts initial observations. Radiology 2002;225:261–68
    PubMedWeb of Science
  55. ↵
    Gonen O, Oberndorfer TA, Inglese M, et al. Reproducibility of 3 whole-brain N-acetylaspartate decline cohorts in relapsing-remitting multiple sclerosis. AJNR Am J Neuroradiol 2007;28:267–71
    Abstract/FREE Full Text
  56. ↵
    Weinshenker BG. Natural history of multiple-sclerosis. Ann Neurol 1994;36:S6–S11
    CrossRefPubMedWeb of Science
  57. ↵
    Rovaris M, Gambini A, Gallo A, et al. Axonal injury in early multiple sclerosis is irreversible and independent of the short-term disease evolution. Neurology 2005;65:1626–30
    Abstract/FREE Full Text
  58. ↵
    Patel SH, Inglese M, Glosser G, et al. Whole-brain N-acetylaspartate level and cognitive performance in HIV infection. AJNR Am J Neuroradiol 2003;24:1587–91
    Abstract/FREE Full Text
  59. ↵
    Medana IM, Esiri MM. Axonal damage: a key predictor of outcome in human CNS diseases. Brain 2003;126:515–30
    Abstract/FREE Full Text
  60. ↵
    Cohen BA, Inglese M, Rusinek H, et al. Proton MR spectroscopy and MRI-volumetry in mild traumatic brain injury. AJNR Am J Neuroradiol 2007;28:907–13
    Abstract/FREE Full Text
  61. ↵
    DeAngelis LM. Brain tumors. N Engl J Med 2001;344:114–23
    CrossRefPubMedWeb of Science
  62. ↵
    Surawicz TS, McCarthy BJ, Kupelian V, et al. Descriptive epidemiology of primary brain and CNS tumors: results from the Central Brain Tumor Registry of the United States, 1990–1994. Neuro Oncol 1999;1:14–25
    PubMed
  63. ↵
    Lunsford LD, Martinez AJ, Latchaw RE. Magnetic resonance imaging does not define tumor boundaries. Acta Radiol Suppl 1986;369:154–56
    PubMed
  64. ↵
    Cohen BA, Knopp EA, Rusinek H, et al. Assessing global invasion of newly diagnosed glial tumors with whole-brain proton MR spectroscopy. AJNR Am J Neuroradiol 2005;26:2170–77
    Abstract/FREE Full Text
  65. ↵
    Inglese M, Brown S, Johnson G, et al. Whole-brain N-acetylaspartate spectroscopy and diffusion tensor imaging in patients with newly diagnosed gliomas: a preliminary study. AJNR Am J Neuroradiol 2006;27:2137–40
    Abstract/FREE Full Text
  66. ↵
    Curnes JT. MR imaging of peripheral intracranial neoplasms: extraaxial vs intraaxial masses. J Comput Assist Tomogr 1987;11:932–37
    PubMed
  67. ↵
    Cohen BA, Knopp EA, Rusinek H, et al. Brain compression without global neuronal loss in meningiomas: whole-brain proton MR spectroscopy report of 2 cases. AJNR Am J Neuroradiol 2005;26:2178–82
    Abstract/FREE Full Text
  68. ↵
    Aupérin A, Arriagada R, PIgnon JP, et al. Prophylactic cranial irradiation for patients with small-cell lung cancer in complete remission. Prophylactic Cranial Irradiation Overview Collaborative Group. N Engl J Med 1999;341:476–84
    CrossRefPubMedWeb of Science
  69. ↵
    Movsas B, Li BS, Babb JS, et al. Quantifying radiation therapy-induced brain injury with whole-brain proton MR spectroscopy: initial observations. Radiology 2001;221:327–31
    CrossRefPubMedWeb of Science
PreviousNext
Back to top

In this issue

American Journal of Neuroradiology: 28 (10)
American Journal of Neuroradiology
Vol. 28, Issue 10
November 2007
  • Table of Contents
  • Index by author
Advertisement
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on American Journal of Neuroradiology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Whole-Brain N-Acetylaspartate as a Surrogate Marker of Neuronal Damage in Diffuse Neurologic Disorders
(Your Name) has sent you a message from American Journal of Neuroradiology
(Your Name) thought you would like to see the American Journal of Neuroradiology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Cite this article
D.J. Rigotti, M. Inglese, O. Gonen
Whole-Brain N-Acetylaspartate as a Surrogate Marker of Neuronal Damage in Diffuse Neurologic Disorders
American Journal of Neuroradiology Nov 2007, 28 (10) 1843-1849; DOI: 10.3174/ajnr.A0774

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
0 Responses
Respond to this article
Share
Bookmark this article
Whole-Brain N-Acetylaspartate as a Surrogate Marker of Neuronal Damage in Diffuse Neurologic Disorders
D.J. Rigotti, M. Inglese, O. Gonen
American Journal of Neuroradiology Nov 2007, 28 (10) 1843-1849; DOI: 10.3174/ajnr.A0774
del.icio.us logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Purchase

Jump to section

  • Article
    • Abstract
    • The Method
    • Longitudinal WBNAA in Healthy Adults
    • WBNAA in MS
    • WBNAA in Other Neurologic Disorders
    • Conclusions
    • Acknowledgments
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • Responses
  • References
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • Longitudinal Evaluation of Magnetic Resonance Spectroscopy Metabolites as Biomarkers in Huntingtons Disease
  • Neuroimaging of Sports Concussions
  • Whole-Brain N-Acetylaspartate Concentration Is Preserved during Mild Hypercapnia Challenge
  • Alzheimer Disease: Focus on Computed Tomography
  • Metabolic Changes in Patients with Aneurysmal Subarachnoid Hemorrhage Apart from Perfusion Deficits: Neuronal Mitochondrial Injury?
  • Two-year serial whole-brain N-acetyl-L-aspartate in patients with relapsing-remitting multiple sclerosis
  • Longitudinal Whole-Brain N-Acetylaspartate Concentration in Healthy Adults
  • Diffuse White Matter Damage Is Absent in Neuromyelitis Optica
  • Vitamin A Deficiency in Rats Induces Anatomic and Metabolic Changes Comparable with Those of Neurodegenerative Disorders
  • Changes in NAA and lactate following ischemic stroke: A serial MR spectroscopic imaging study
  • Crossref (85)
  • Google Scholar

This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.

  • Clinical Proton MR Spectroscopy in Central Nervous System Disorders
    Gülin Öz, Jeffry R. Alger, Peter B. Barker, Robert Bartha, Alberto Bizzi, Chris Boesch, Patrick J. Bolan, Kevin M. Brindle, Cristina Cudalbu, Alp Dinçer, Ulrike Dydak, Uzay E. Emir, Jens Frahm, Ramón Gilberto González, Stephan Gruber, Rolf Gruetter, Rakesh K. Gupta, Arend Heerschap, Anke Henning, Hoby P. Hetherington, Franklyn A. Howe, Petra S. Hüppi, Ralph E. Hurd, Kejal Kantarci, Dennis W. J. Klomp, Roland Kreis, Marijn J. Kruiskamp, Martin O. Leach, Alexander P. Lin, Peter R. Luijten, Małgorzata Marjańska, Andrew A. Maudsley, Dieter J. Meyerhoff, Carolyn E. Mountford, Sarah J. Nelson, M. Necmettin Pamir, Jullie W. Pan, Andrew C. Peet, Harish Poptani, Stefan Posse, Petra J. W. Pouwels, Eva-Maria Ratai, Brian D. Ross, Tom W. J. Scheenen, Christian Schuster, Ian C. P. Smith, Brian J. Soher, Ivan Tkáč, Daniel B. Vigneron, Risto A. Kauppinen
    Radiology 2014 270 3
  • Assessment of metabolic brain damage and recovery following mild traumatic brain injury: a multicentre, proton magnetic resonance spectroscopic study in concussed patients
    R. Vagnozzi, S. Signoretti, L. Cristofori, F. Alessandrini, R. Floris, E. Isgro, A. Ria, S. Marziale, G. Zoccatelli, B. Tavazzi, F. Del Bolgia, R. Sorge, S. P. Broglio, T. K. McIntosh, G. Lazzarino
    Brain 2010 133 11
  • Neuroimaging creativity: A psychometric view
    Rosalind Arden, Robert S. Chavez, Rachael Grazioplene, Rex E. Jung
    Behavioural Brain Research 2010 214 2
  • In vivo imaging of neuroinflammation in schizophrenia
    Ofer Pasternak, Marek Kubicki, Martha E. Shenton
    Schizophrenia Research 2016 173 3
  • Rapid optofluidic detection of biomarkers for traumatic brain injury via surface-enhanced Raman spectroscopy
    Jonathan J. S. Rickard, Valentina Di-Pietro, David J. Smith, David J. Davies, Antonio Belli, Pola Goldberg Oppenheimer
    Nature Biomedical Engineering 2020 4 6
  • Proton Magnetic Resonance Spectroscopy in Multiple Sclerosis
    Balasrinivasa R. Sajja, Jerry S. Wolinsky, Ponnada A. Narayana
    Neuroimaging Clinics of North America 2009 19 1
  • Non-invasive metabolic imaging of brain tumours in the era of precision medicine
    Michelle M. Kim, Abhijit Parolia, Mark P. Dunphy, Sriram Venneti
    Nature Reviews Clinical Oncology 2016 13 12
  • Changes in NAA and lactate following ischemic stroke
    S. Muñoz Maniega, V. Cvoro, F. M. Chappell, P. A. Armitage, I. Marshall, M. E. Bastin, J. M. Wardlaw
    Neurology 2008 71 24
  • Disease Biomarkers in Multiple Sclerosis
    Violaine K. Harris, Saud A. Sadiq
    Molecular Diagnosis & Therapy 2009 13 4
  • Decrease in N-Acetylaspartate Following Concussion May Be Coupled to Decrease in Creatine
    Roberto Vagnozzi, Stefano Signoretti, Roberto Floris, Simone Marziali, Massimo Manara, Angela M. Amorini, Antonio Belli, Valentina Di Pietro, Serafina D'Urso, Francesco S. Pastore, Giuseppe Lazzarino, Barbara Tavazzi
    Journal of Head Trauma Rehabilitation 2013 28 4

More in this TOC Section

  • An Atlas of Neonatal Neurovascular Imaging Anatomy as Depicted with Microvascular Imaging: The Intracranial Arteries
  • An Atlas of Neonatal Neurovascular Imaging Anatomy as Depicted with Microvascular Imaging: The Intracranial Veins
  • Clinical Translation of Hyperpolarized 13C Metabolic Probes for Glioma Imaging
Show more Review articles

Similar Articles

Advertisement

Indexed Content

  • Current Issue
  • Accepted Manuscripts
  • Article Preview
  • Past Issues
  • Editorials
  • Editor's Choice
  • Fellows' Journal Club
  • Letters to the Editor
  • Video Articles

Cases

  • Case Collection
  • Archive - Case of the Week
  • Archive - Case of the Month
  • Archive - Classic Case

More from AJNR

  • Trainee Corner
  • Imaging Protocols
  • MRI Safety Corner
  • Book Reviews

Multimedia

  • AJNR Podcasts
  • AJNR Scantastics

Resources

  • Turnaround Time
  • Submit a Manuscript
  • Submit a Video Article
  • Submit an eLetter to the Editor/Response
  • Manuscript Submission Guidelines
  • Statistical Tips
  • Fast Publishing of Accepted Manuscripts
  • Graphical Abstract Preparation
  • Imaging Protocol Submission
  • Evidence-Based Medicine Level Guide
  • Publishing Checklists
  • Author Policies
  • Become a Reviewer/Academy of Reviewers
  • News and Updates

About Us

  • About AJNR
  • Editorial Board
  • Editorial Board Alumni
  • Alerts
  • Permissions
  • Not an AJNR Subscriber? Join Now
  • Advertise with Us
  • Librarian Resources
  • Feedback
  • Terms and Conditions
  • AJNR Editorial Board Alumni

American Society of Neuroradiology

  • Not an ASNR Member? Join Now

© 2025 by the American Society of Neuroradiology All rights, including for text and data mining, AI training, and similar technologies, are reserved.
Print ISSN: 0195-6108 Online ISSN: 1936-959X

Powered by HighWire