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Research ArticleBRAIN

Do Transient Ischemic Attacks with Diffusion-Weighted Imaging Abnormalities Correspond to Brain Infarctions?

C. Oppenheim, C. Lamy, E. Touzé, D. Calvet, M. Hamon, J.-L. Mas and J.-F. Méder
American Journal of Neuroradiology September 2006, 27 (8) 1782-1787;
C. Oppenheim
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C. Lamy
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E. Touzé
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D. Calvet
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M. Hamon
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J.-L. Mas
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J.-F. Méder
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    Fig 1.

    A 67-year-old man with a left sensory-motor deficit for 30 minutes. Initial MR imaging (3 days after onset) demonstrates a small DWI and FLAIR hyperintensity in the deep right middle cerebral artery (MCA) territory. On follow-up MR imaging (14 months after onset), focal signal intensity changes on all sequences indicate permanent injury in the corresponding area.

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    Fig 2.

    A 63-year-old man with a right sensory deficit for 10 hours. Initial MR imaging (63 hours after onset) demonstrates a focal DWI and FLAIR hyperintensity in the left brain stem (arrow). On follow-up MR imaging (6 months after onset), a small permanent injury can be seen as a dark signal intensity on T1-weighted sequence and a bright signal intensity on FLAIR/T2-weighted sequence in the corresponding area.

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    Fig 3.

    A 55-year-old man with sensory-motor deficit of the upper right limb for 90 minutes. Initial MR imaging (10 hours after onset) demonstrates a focal DWI hyperintensity with mild FLAIR signal intensity changes in the left primary motor cortex, matching clinical symptoms. On follow-up MR imaging (8 months after onset), no permanent injury can be identified.

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    Fig 4.

    A 21-year-old woman with a right sensory-motor deficit and aphasia for 60 minutes. Initial MR imaging (4 days after onset) shows a punctate cortical DWI/FLAIR hyperintensity in the left superficial middle cerebral artery (MCA) territory. On follow-up MR imaging (15 months after onset), a small permanent injury can be seen as a bright cortical dot on T1-weighted sequence with mild atrophy on T2-weighted sequence. Note that no signal intensity change is seen on FLAIR.

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    Table 1:

    Characteristics of transient ischemic attack (TIA) patients with and without infarction on follow-up MR imaging (MRI)

    Reversible (n = 7)Infarction (n = 26)All Patients (n = 33)P Value
    Male, %5 (71%)18 (70%)23 (69%)1
    Age, y (mean ± SD)58 ± 1561 ± 1760 ± 16.5
    Symptoms
        Duration, min (mean ± SD)76 ± 85188 ± 253201 ± 262.2
        Duration <60 min3 (43%)10 (38%)13 (39%)1
    Multiple TIA events3 (43%)10 (38%)13 (39%)1
    Identified cause, %3 (43%)12 (46%)15 (45%)1
    Initial MRI
        Delay from onset MRI, h21 ± 1033 ± 3630 ± 33.9
        Solitary lesions6 (86%)11 (42%)17 (51.5%).08
    Follow-up MRI
        Delay from onset MRI, mo11.6 ± 3.110.4 ± 5.510.6 ± 5.75
    • Note:— Patients with multiple lesions of different outcome are classed in the infarction group.

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    Table 2:

    Quantitative diffusion-weighted MR imaging (DWI)–derived variables of the 59 transient ischemic attack (TIA) lesions according to imaging outcome

    Reversible (n = 14)Infarction (n = 45)P Value
    DWI volume, cm3 (mean ± SD)0.21 ± 0.210.91 ± 1.7.003
    Absolute ADC, 10−6 mm2/s (mean ± SD)722 ± 118631 ± 135.022
    rADC (mean ± SD)91 ± 9%79 ± 15%.001
    • Note:— rADC corresponds to apparent diffusion coefficient (ADC) within the TIA lesion divided by the mirror ADC value.

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American Journal of Neuroradiology: 27 (8)
American Journal of Neuroradiology
Vol. 27, Issue 8
September 2006
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C. Oppenheim, C. Lamy, E. Touzé, D. Calvet, M. Hamon, J.-L. Mas, J.-F. Méder
Do Transient Ischemic Attacks with Diffusion-Weighted Imaging Abnormalities Correspond to Brain Infarctions?
American Journal of Neuroradiology Sep 2006, 27 (8) 1782-1787;

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Do Transient Ischemic Attacks with Diffusion-Weighted Imaging Abnormalities Correspond to Brain Infarctions?
C. Oppenheim, C. Lamy, E. Touzé, D. Calvet, M. Hamon, J.-L. Mas, J.-F. Méder
American Journal of Neuroradiology Sep 2006, 27 (8) 1782-1787;
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  • Reporting Standards for Endovascular Repair of Saccular Intracranial Cerebral Aneurysms
  • Definition and Evaluation of Transient Ischemic Attack: A Scientific Statement for Healthcare Professionals From the American Heart Association/American Stroke Association Stroke Council; Council on Cardiovascular Surgery and Anesthesia; Council on Cardiovascular Radiology and Intervention; Council on Cardiovascular Nursing; and the Interdisciplinary Council on Peripheral Vascular Disease: The American Academy of Neurology affirms the value of this statement as an educational tool for neurologists.
  • Reporting Standards for Endovascular Repair of Saccular Intracranial Cerebral Aneurysms
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  • Multimodal CT Provides Improved Performance for Lacunar Infarct Detection
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  • Evaluating the Effects of White Matter Multiple Sclerosis Lesions on the Volume Estimation of 6 Brain Tissue Segmentation Methods
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