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OtherPediatric Neuroimaging

Sequential MR Imaging Changes in Nonketotic Hyperglycinemia

J. Mourmans, C.B.L.M. Majoie, P.G. Barth, M. Duran, E.M. Akkerman and B.T. Poll-The
American Journal of Neuroradiology January 2006, 27 (1) 208-211;
J. Mourmans
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C.B.L.M. Majoie
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P.G. Barth
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M. Duran
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E.M. Akkerman
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B.T. Poll-The
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    Fig 1.

    MR images at the age of 3 weeks.

    A, Axial fast spin-echo T2-weighted MR image (3500/90/1) shows high signal intensity in the posterior limbs of the internal capsules suggesting abnormal myelin.

    B, Diffusion-weighted MR image demonstrates high signal intensity in the posterior limb of the internal capsule.

    C, ADC map corresponding to area in panel B shows decreased ADC values in these areas consistent with restricted diffusion.

    D, Color-coded fractional anisotropy-map demonstrates preservation of fractional anisotropy in white matter tracts. Red refers to FA = 1 and purple to FA = 0.

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    Fig 2.

    MR images at the age of 3 months.

    A, Axial fast spin-echo T2-weighted MR image (3500/90/1) shows high signal intensity in the entire internal capsules and the optic radiations.

    B, Diffusion-weighted MR image shows increased signal intensity in the areas indicated in panel A and to a lesser degree throughout the white matter.

    C, ADC map corresponding to area in panel B shows decreased ADC values consistent with restricted diffusion.

    D, Color-coded fractional anisotropy map demonstrates preservation of FA in white matter tracts, and increase in FA as compared with Fig 1D.

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    Fig 3.

    MR images at the age of 17 months.

    A, Diffusion-weighted MR image shows atrophy and disappearance of diffusion restriction in the bilateral internal capsules and optic radiations.

    B, Color-coded FA map demonstrates FA decrease compared with Fig 2D, indicative of axonal loss.

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American Journal of Neuroradiology: 27 (1)
American Journal of Neuroradiology
Vol. 27, Issue 1
January, 2006
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Cite this article
J. Mourmans, C.B.L.M. Majoie, P.G. Barth, M. Duran, E.M. Akkerman, B.T. Poll-The
Sequential MR Imaging Changes in Nonketotic Hyperglycinemia
American Journal of Neuroradiology Jan 2006, 27 (1) 208-211;

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Sequential MR Imaging Changes in Nonketotic Hyperglycinemia
J. Mourmans, C.B.L.M. Majoie, P.G. Barth, M. Duran, E.M. Akkerman, B.T. Poll-The
American Journal of Neuroradiology Jan 2006, 27 (1) 208-211;
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